nach oben

Erschienen in:

08.04.2020 | Original Article

Cardio-respiratory, oxidative stress and acute mountain sickness responses to normobaric and hypobaric hypoxia in prematurely born adults

verfasst von: Tadej Debevec, Vincent Pialoux, Mathias Poussel, Sarah J. Willis, Agnès Martin, Damjan Osredkar, Grégoire P. Millet

Erschienen in: European Journal of Applied Physiology | Ausgabe 6/2020

Einloggen, um Zugang zu erhalten

Abstract

Purpose

We compared the effects of hypobaric and normobaric hypoxia on select cardio-respiratory responses, oxidative stress and acute mountain sickness (AMS) severity in prematurely born individuals, known to exhibit blunted hypoxic ventilatory response.

Methods

Sixteen prematurely born but otherwise healthy males underwent two 8-h hypoxic exposures under: (1) hypobaric hypoxic [HH; terrestrial altitude 3840 m; P_iO₂:90.2 (0.5) mmHg; BP: 478 (2) mmHg] and (2) normobaric hypoxic [NH; P_iO₂:90.6 (0.9) mmHg; F_iO₂:0.142 (0.001)] condition. Resting values of capillary oxyhemoglobin saturation (SpO₂), heart rate (HR) and blood pressure were measured before and every 2 h during the exposures. Ventilatory responses and middle cerebral artery blood flow velocity (MCAv) were assessed at rest and during submaximal cycling before and at 4 and 8 h. Plasmatic levels of selected oxidative stress and antioxidant markers and AMS symptoms were also determined at these time points.

Results

HH resulted in significantly lower resting (P = 0.010) and exercise (P = 0.004) SpO₂ as compared to NH with no significant differences in the ventilatory parameters, HR or blood pressure. No significant differences between conditions were found in resting or exercising MCAv and measured oxidative stress markers. Significantly lower values of ferric-reducing antioxidant power (P = 0.037) were observed during HH as opposed to NH. AMS severity was higher at 8 h compared to baseline (P = 0.002) with no significant differences between conditions.

Conclusion

These data suggest that, in prematurely born adults, 8-h exposure to hypobaric, as opposed to normobaric hypoxia, provokes greater reductions in systemic oxygenation and antioxidant capacity. Further studies investigating prolonged hypobaric exposures in this population are warranted.

Registration

NCT02780908 (ClinicalTrials.gov).

Aebi MR, Bourdillon N, Kunz A, Bron D, Millet GP (2020) Specific effect of hypobaria on cerebrovascular hypercapnic responses in hypoxia. Physiol Rep 8(4):e14372. https://doi.org/10.14814/phy2.14372 CrossRefPubMedPubMedCentral

Ainslie PN, Ogoh S (2010) Regulation of cerebral blood flow in mammals during chronic hypoxia: a matter of balance. Exp Physiol 95(2):251–262. https://doi.org/10.1113/expphysiol.2008.045575 CrossRefPubMed

Ainslie PN, Hoiland RL, Bailey DM (2016) Lessons from the laboratory; integrated regulation of cerebral blood flow during hypoxia. Exp Physiol 101(9):1160–1166. https://doi.org/10.1113/EP085671 CrossRefPubMed

American College of R, Society for Pediatric R, Society of Radiologists in U (2012) AIUM practice guideline for the performance of a transcranial Doppler ultrasound examination for adults and children. J Ultrasound Med 31(9):1489–1500. https://doi.org/10.7863/jum.2012.31.9.1489 CrossRef

Bates ML, Farrell ET, Eldridge MW (2014) Abnormal ventilatory responses in adults born prematurely. N Engl J Med 370(6):584–585. https://doi.org/10.1056/NEJMc1311092 CrossRefPubMedPubMedCentral

Berger MM, Sareban M, Bartsch P (2019) Acute mountain sickness: do different time courses point to different pathophysiologic mechanisms? J Appl Physiol (1985). https://doi.org/10.1152/japplphysiol.00305.2019 CrossRef

Bisgard GE, Olson EB Jr, Wang ZY, Bavis RW, Fuller DD, Mitchell GS (2003) Adult carotid chemoafferent responses to hypoxia after 1, 2, and 4 week of postnatal hyperoxia. J Appl Physiol (1985) 95(3):946–952. https://doi.org/10.1152/japplphysiol.00985.2002 CrossRef

Booth J (1977) A short history of blood pressure measurement. Proc R Soc Med 70(11):793–799PubMedPubMedCentral

Conkin J (2016) Equivalent air altitude and the alveolar gas equation. Aerosp Med Hum Perform 87(1):61–64. https://doi.org/10.3357/AMHP.4421.2016 CrossRefPubMed

Conkin J, Wessel JH III (2008) Critique of the equivalent air altitude model. Aviat Space Environ Med 79(10):975–982CrossRef

Debevec T, Millet GP (2014) Discerning normobaric and hypobaric hypoxia: significance of exposure duration. J Appl Physiol (1985) 116(9):1255. https://doi.org/10.1152/japplphysiol.00873.2013 CrossRef

Debevec T, Pialoux V, Millet GP, Martin A, Mramor M, Osredkar D (2019) Exercise overrides blunted hypoxic ventilatory response in prematurely born men. Front Physiol 10:437. https://doi.org/10.3389/fphys.2019.00437 CrossRefPubMedPubMedCentral

DiPasquale DM, Strangman GE, Harris NS, Muza SR (2015) Hypoxia, hypobaria, and exercise duration affect acute mountain sickness. Aerosp Med Hum Perform 86(7):614–619. https://doi.org/10.3357/AMHP.4266.2015 CrossRefPubMed

DiPasquale DM, Muza SR, Gunn AM, Li Z, Zhang Q, Harris NS, Strangman GE (2016) Evidence for cerebral edema, cerebral perfusion, and intracranial pressure elevations in acute mountain sickness. Brain Behav 6(3):e00437. https://doi.org/10.1002/brb3.437 CrossRefPubMedPubMedCentral

Duke JW, Elliott JE, Laurie SS, Beasley KM, Mangum TS, Hawn JA, Gladstone IM, Lovering AT (2014) Pulmonary gas exchange efficiency during exercise breathing normoxic and hypoxic gas in adults born very preterm with low diffusion capacity. J Appl Physiol (1985) 117(5):473–481. https://doi.org/10.1152/japplphysiol.00307.2014 CrossRef

Faiss R, Pialoux V, Sartori C, Faes C, Deriaz O, Millet GP (2013) Ventilation, oxidative stress and nitric oxide in hypobaric vs normobaric hypoxia. Med Sci Sports Exerc 45(2):253–260. https://doi.org/10.1249/MSS.0b013e31826d5aa2 CrossRefPubMed

Farrell ET, Bates ML, Pegelow DF, Palta M, Eickhoff JC, O'Brien MJ, Eldridge MW (2015) Pulmonary gas exchange and exercise capacity in adults born preterm. Ann Am Thorac Soc 12(8):1130–1137. https://doi.org/10.1513/AnnalsATS.201410-470OC CrossRefPubMedPubMedCentral

Filippone M, Bonetto G, Corradi M, Frigo AC, Baraldi E (2012) Evidence of unexpected oxidative stress in airways of adolescents born very pre-term. Eur Respir J 40(5):1253–1259. https://doi.org/10.1183/09031936.00185511 CrossRefPubMed

Halliwell B, Whiteman M (2004) Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? Br J Pharmacol 142(2):231–255. https://doi.org/10.1038/sj.bjp.0705776 CrossRefPubMedPubMedCentral

Imray C, Wright A, Subudhi A, Roach R (2010) Acute mountain sickness: pathophysiology, prevention, and treatment. Prog Cardiovasc Dis 52(6):467–484. https://doi.org/10.1016/j.pcad.2010.02.003 CrossRefPubMed

Katz-Salamon M, Lagercrantz H (1994) Hypoxic ventilatory defence in very preterm infants: attenuation after long term oxygen treatment. Arch Dis Child Fetal Neonatal Ed 70(2):F90–95CrossRef

Loeppky JA, Scotto P, Roach RC (1996) Acute ventilatory response to simulated altitude, normobaric hypoxia, and hypobaria. Aviat Space Environ Med 67(11):1019–1022PubMed

Loeppky JA, Icenogle M, Scotto P, Robergs R, Hinghofer-Szalkay H, Roach RC (1997) Ventilation during simulated altitude, normobaric hypoxia and normoxic hypobaria. Respir Physiol 107(3):231–239CrossRef

Lovering AT, Laurie SS, Elliott JE, Beasley KM, Yang X, Gust CE, Mangum TS, Goodman RD, Hawn JA, Gladstone IM (2013) Normal pulmonary gas exchange efficiency and absence of exercise-induced arterial hypoxemia in adults with bronchopulmonary dysplasia. J Appl Physiol (1985) 115(7):1050–1056. https://doi.org/10.1152/japplphysiol.00592.2013 CrossRef

Lovering AT, Elliott JE, Laurie SS, Beasley KM, Gust CE, Mangum TS, Gladstone IM, Duke JW (2014) Ventilatory and sensory responses in adult survivors of preterm birth and bronchopulmonary dysplasia with reduced exercise capacity. Ann Am Thorac Soc 11(10):1528–1537. https://doi.org/10.1513/AnnalsATS.201312-466OC CrossRefPubMed

Luks AM, Swenson ER, Bartsch P (2017) Acute high-altitude sickness. Eur Respir Rev. https://doi.org/10.1183/16000617.0096-2016 CrossRefPubMed

Magalhaes J, Ascensao A, Viscor G, Soares J, Oliveira J, Marques F, Duarte J (2004) Oxidative stress in humans during and after 4 h of hypoxia at a simulated altitude of 5500 m. Aviat Space Environ Med 75(1):16–22PubMed

Margaritelis NV, Cobley JN, Paschalis V, Veskoukis AS, Theodorou AA, Kyparos A, Nikolaidis MG (2016) Principles for integrating reactive species into in vivo biological processes: examples from exercise physiology. Cell Signal 28(4):256–271. https://doi.org/10.1016/j.cellsig.2015.12.011 CrossRefPubMed

Martin A, Faes C, Debevec T, Rytz C, Millet G, Pialoux V (2018) Preterm birth and oxidative stress: effects of acute physical exercise and hypoxia physiological responses. Redox Biol 17:315–322. https://doi.org/10.1016/j.redox.2018.04.022 CrossRefPubMedPubMedCentral

Martin A, Millet G, Osredkar D, Mramor M, Faes C, Gouraud E, Debevec T, Pialoux V (2020) Effect of pre-term birth on oxidative stress responses to normoxic and hypoxic exercise. Redox Biol. https://doi.org/10.1016/j.redox.2020.101497 CrossRefPubMedPubMedCentral

McLeod A, Ross P, Mitchell S, Tay D, Hunter L, Hall A, Paton J, Mutch L (1996) Respiratory health in a total very low birthweight cohort and their classroom controls. Arch Dis Child 74(3):188–194CrossRef

Millet GP, Debevec T (2020) CrossTalk proposal: barometric pressure, independent of PO₂, is the forgotten parameter in altitude physiology and mountain medicine. J Physiol 598(5):893–896. https://doi.org/10.1113/JP278673 CrossRefPubMed

Millet GP, Faiss R, Pialoux V, Mounier R, Brugniaux JV (2012) Point: Counterpoint: Hypobaric hypoxia induces/does not induce different responses from normobaric hypoxia. J Appl Physiol 112(10):1783–1784. https://doi.org/10.1152/japplphysiol.00067.2012 CrossRefPubMed

Moore LG, Harrison GL, McCullough RE, McCullough RG, Micco AJ, Tucker A, Weil JV, Reeves JT (1986) Low acute hypoxic ventilatory response and hypoxic depression in acute altitude sickness. J Appl Physiol (1985) 60(4):1407–1412. https://doi.org/10.1152/jappl.1986.60.4.1407 CrossRef

Nespoulet H, Wuyam B, Tamisier R, Saunier C, Monneret D, Remy J, Chabre O, Pepin JL, Levy P (2012) Altitude illness is related to low hypoxic chemoresponse and low oxygenation during sleep. Eur Respir J 40(3):673–680. https://doi.org/10.1183/09031936.00073111 CrossRefPubMed

Ogoh S (2015) Cerebral blood flow regulation during hypoxia. Exp Physiol 100(2):109–110. https://doi.org/10.1113/expphysiol.2014.084202 CrossRefPubMed

Palta M, Sadek-Badawi M, Madden K, Green C (2007) Pulmonary testing using peak flow meters of very low birth weight children born in the perisurfactant era and school controls at age 10 years. Pediatr Pulmonol 42(9):819–828. https://doi.org/10.1002/ppul.20662 CrossRefPubMed

Pialoux V, Brugniaux JV, Fellmann N, Richalet JP, Robach P, Schmitt L, Coudert J, Mounier R (2009a) Oxidative stress and HIF-1 alpha modulate hypoxic ventilatory responses after hypoxic training on athletes. Respir Physiol Neurobiol 167(2):217–220CrossRef

Pialoux V, Hanly PJ, Foster GE, Brugniaux JV, Beaudin AE, Hartmann SE, Pun M, Duggan CT, Poulin MJ (2009b) Effects of exposure to intermittent hypoxia on oxidative stress and acute hypoxic ventilatory response in humans. Am J Respir Crit Care Med 180(10):1002–1009. https://doi.org/10.1164/rccm.200905-0671OC CrossRefPubMed

Pialoux V, Mounier R, Rock E, Mazur A, Schmitt L, Richalet JP, Robach P, Coudert J, Fellmann N (2009c) Effects of acute hypoxic exposure on prooxidant/antioxidant balance in elite endurance athletes. Int J Sports Med 30(2):87–93. https://doi.org/10.1055/s-0028-1103284 CrossRefPubMed

Ribon A, Pialoux V, Saugy JJ, Rupp T, Faiss R, Debevec T, Millet GP (2016) Exposure to hypobaric hypoxia results in higher oxidative stress compared to normobaric hypoxia. Respir Physiol Neurobiol 223:23–27. https://doi.org/10.1016/j.resp.2015.12.008 CrossRefPubMed

Richard NA, Sahota IS, Widmer N, Ferguson S, Sheel AW, Koehle MS (2014) Acute mountain sickness, chemosensitivity and cardio-respiratory responses in humans exposed to hypobaric and normobaric hypoxia. J Appl Physiol 116(7):945–952. https://doi.org/10.1152/japplphysiol.00319.2013 CrossRefPubMed

Roach RC, Loeppky JA, Icenogle MV (1996) Acute mountain sickness: increased severity during simulated altitude compared with normobaric hypoxia. J Appl Physiol 81(5):1908–1910CrossRef

Roach RC, Hackett PH, Oelz O, Bartsch P, Luks AM, MacInnis MJ, Baillie JK, Lake Louise AMSSCC (2018) The 2018 Lake Louise Acute Mountain Sickness Score. High Alt Med Biol 19(1):4–6. https://doi.org/10.1089/ham.2017.0164 CrossRefPubMedPubMedCentral

Rupp T, Saugy JJ, Bourdillon N, Verges S, Millet GP (2019) Positive expiratory pressure improves arterial and cerebral oxygenation in acute normobaric and hypobaric hypoxia. Am J Physiol Regul Integr Comp Physiol. https://doi.org/10.1152/ajpregu.00025.2019 CrossRefPubMed

Savourey G, Launay JC, Besnard Y, Guinet A, Travers S (2003) Normo- and hypobaric hypoxia: are there any physiological differences? Eur J Appl Physiol 89(2):122–126. https://doi.org/10.1007/s00421-002-0789-8 CrossRefPubMed

Smith LJ, van Asperen PP, McKay KO, Selvadurai H, Fitzgerald DA (2008) Reduced exercise capacity in children born very preterm. Pediatrics 122(2):e287–293. https://doi.org/10.1542/peds.2007-3657 CrossRefPubMed

Steinback CD, Poulin MJ (2016) Influence of hypoxia on cerebral blood flow regulation in humans. Adv Exp Med Biol 903:131–144. https://doi.org/10.1007/978-1-4899-7678-9_9 CrossRefPubMed

Vogel JP, Chawanpaiboon S, Moller AB, Watananirun K, Bonet M, Lumbiganon P (2018) The global epidemiology of preterm birth. Best Pract Res Clin Obstet Gynaecol 52:3–12. https://doi.org/10.1016/j.bpobgyn.2018.04.003 CrossRefPubMed

Wang J, Brown MA, Tam SH, Chan MC, Whitworth JA (1997) Effects of diet on measurement of nitric oxide metabolites. Clin Exp Pharmacol Physiol 24(6):418–420CrossRef

Titel: Cardio-respiratory, oxidative stress and acute mountain sickness responses to normobaric and hypobaric hypoxia in prematurely born adults
verfasst von: Tadej Debevec
Vincent Pialoux
Mathias Poussel
Sarah J. Willis
Agnès Martin
Damjan Osredkar
Grégoire P. Millet
Publikationsdatum: 08.04.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Applied Physiology / Ausgabe 6/2020
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-020-04366-w

Neu im Fachgebiet Arbeitsmedizin

Open Access 27.03.2024 | ADHS | Leitthema

Elterliches Belastungserleben, Unaufmerksamkeits‑/Hyperaktivitätssymptome und elternberichtete ADHS bei Kindern und Jugendlichen: Ergebnisse aus der KiGGS-Studie

Open Access 25.03.2024 | Leitthema

Substanzkonsum und Nutzung von sozialen Medien, Computerspielen und Glücksspielen unter Auszubildenden an beruflichen Schulen

19.03.2024 | Leitthema

Berufsbelastung und Stressbewältigung von weiblichen und männlichen Auszubildenden

19.03.2024 | COVID-19 | Leitthema

Rauschtrinken in der frühen Adoleszenz

Ergebnisse des Präventionsradars von 2016 bis 2023

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

Registration

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2020

Three-dimensional regional bi-ventricular shape remodeling is associated with exercise capacity in endurance athletes

Added lower limb mass does not affect biomechanical asymmetry but increases metabolic power in runners with a unilateral transtibial amputation

Acute hypertrophic but not maximal strength loading transiently enhances the kynurenine pathway towards kynurenic acid

Dietary nitrate does not acutely enhance skeletal muscle blood flow and vasodilation in the lower limbs of older adults during single-limb exercise

Biomechanics of handcycling propulsion in a 30-min continuous load test at lactate threshold: Kinetics, kinematics, and muscular activity in able-bodied participants

A model-based estimation of critical torques reduces the experimental effort compared to conventional testing

Neu im Fachgebiet Arbeitsmedizin

Elterliches Belastungserleben, Unaufmerksamkeits‑/Hyperaktivitätssymptome und elternberichtete ADHS bei Kindern und Jugendlichen: Ergebnisse aus der KiGGS-Studie

Substanzkonsum und Nutzung von sozialen Medien, Computerspielen und Glücksspielen unter Auszubildenden an beruflichen Schulen

Berufsbelastung und Stressbewältigung von weiblichen und männlichen Auszubildenden

Rauschtrinken in der frühen Adoleszenz