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Erschienen in:

10.06.2024 | Review

Cardioprotection in cardiovascular surgery

verfasst von: Sharif A. Sabe, Dwight D. Harris, Mark Broadwin, Frank W. Sellke

Erschienen in: Basic Research in Cardiology | Ausgabe 4/2024

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Abstract

Since the invention of cardiopulmonary bypass, cardioprotective strategies have been investigated to mitigate ischemic injury to the heart during aortic cross-clamping and reperfusion injury with cross-clamp release. With advances in cardiac surgical and percutaneous techniques and post-operative management strategies including mechanical circulatory support, cardiac surgeons are able to operate on more complex patients. Therefore, there is a growing need for improved cardioprotective strategies to optimize outcomes in these patients. This review provides an overview of the basic principles of cardioprotection in the setting of cardiac surgery, including mechanisms of cardiac injury in the context of cardiopulmonary bypass, followed by a discussion of the specific approaches to optimizing cardioprotection in cardiac surgery, including refinements in cardiopulmonary bypass and cardioplegia, ischemic conditioning, use of specific anesthetic and pharmaceutical agents, and novel mechanical circulatory support technologies. Finally, translational strategies that investigate cardioprotection in the setting of cardiac surgery will be reviewed, with a focus on promising research in the areas of cell-based and gene therapy. Advances in this area will help cardiologists and cardiac surgeons mitigate myocardial ischemic injury, improve functional post-operative recovery, and optimize clinical outcomes in patients undergoing cardiac surgery.

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Titel: Cardioprotection in cardiovascular surgery
verfasst von: Sharif A. Sabe
Dwight D. Harris
Mark Broadwin
Frank W. Sellke
Publikationsdatum: 10.06.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: Basic Research in Cardiology / Ausgabe 4/2024
Print ISSN: 0300-8428
Elektronische ISSN: 1435-1803
DOI: https://doi.org/10.1007/s00395-024-01062-0

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Exercise training decreases lactylation and prevents myocardial ischemia–reperfusion injury by inhibiting YTHDF2

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Springer Medizin

Cardioprotection in cardiovascular surgery

Abstract

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Exercise training decreases lactylation and prevents myocardial ischemia–reperfusion injury by inhibiting YTHDF2

Kompaktes Leitlinien-Wissen Innere Medizin (Link öffnet in neuem Fenster)

Neu im Fachgebiet Kardiologie

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LVAD auch bei kalt-trockener terminaler Herzinsuffizienz wirksam

EKG Essentials: EKG befunden mit System (Link öffnet in neuem Fenster)

Update Kardiologie

Springer Medizin

Abstract

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