Ausgabe Sonderheft 1/2011
An Arginine-Vasopressin V2 receptor Antagonist, Tolvaptan, for Treatment of Heart Failure with Volume Overload - Evidence from Nonclinical Studies to Clinical Trials
Inhalt (11 Artikel)
Pharmacokinetics, Pharmacodynamics and Safety of Tolvaptan, A Novel, Oral, Selective Nonpeptide AVP V2-receptor Antagonist: Results of Single- and Multiple-Dose Studies in Healthy Japanese Male Volunteers
Seong Ryul Kim, Tomoko Hasunuma, Osamu Sato, Tadashi Okada, Mitsuhiro Kondo, Junichi Azuma
Effects of Tolvaptan on Volume Overload in Japanese Patients with Heart Failure: Results of a Phase II, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study
Masunori Matsuzaki, Masatsugu Hori, Tohru Izumi, Hidetsugu Asanoi, Takayoshi Tsutamoto
Efficacy and Safety of Tolvaptan in Heart Failure Patients with Volume Overload Despite the Standard Treatment with Conventional Diuretics: A Phase III, Randomized, Double-blind, Placebo-controlled Study (QUEST Study)
Masunori Matsuzaki, Masatsugu Hori, Tohru Izumi, Masatake Fukunami
Efficacy and Safety of Tolvaptan in Heart Failure Patients with Sustained Volume Overload despite the Use of Conventional Diuretics: A Phase III Open-Label Study
Masatake Fukunami, Masunori Matsuzaki, Masatsugu Hori, Tohru Izumi
Phase III Clinical Pharmacology Study of Tolvaptan
Takayuki Inomata, Tohru Izumi, Masunori Matsuzaki, Masatsugu Hori, Atsushi Hirayama
Effects of Tolvaptan on Systemic and Renal Hemodynamic Function in Dogs with Congestive Heart Failure
Toshiyuki Onogawa, Yuki Sakamoto, Shigeki Nakamura, Sunao Nakayama, Hiroyuki Fujiki, Yoshitaka Yamamura
Anti-edematous Effects of Tolvaptan in Experimental Rodent Models
Toshiki Miyazaki, Yuki Sakamoto, Tatsuya Yamashita, Koji Ohmoto, Hiroyuki Fujiki
Nonclinical Pharmacokinetics of a New Nonpeptide V2 Receptor Antagonist, Tolvaptan
Masayuki Furukawa, Ken Umehara, Eiji Kashiyama
Nonclinical Safety Profile of Tolvaptan
Akihide Oi, Katsumi Morishita, Takumi Awogi, Atsushi Ozaki, Masanao Umezato, Shinji Fujita, Eiji Hosoki, Hajime Morimoto, Nobuya Ishiharada, Hironobu Ishiyama, Tohru Uesugi, Masaya Miyatake, Tadashi Senba, Toshiyuki Shiragiku, Naoto Nakagiri, Norio Ito