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01.12.2014 | Research | Ausgabe 1/2014 Open Access

Journal of Cardiovascular Magnetic Resonance 1/2014

Cardiovascular magnetic resonance in pregnancy: Insights from the cardiac hemodynamic imaging and remodeling in pregnancy (CHIRP) study

Journal of Cardiovascular Magnetic Resonance > Ausgabe 1/2014
Robin A Ducas, Jason E Elliott, Steven F Melnyk, Sheena Premecz, Megan daSilva, Kelby Cleverley, Piotr Wtorek, G Scott Mackenzie, Michael E Helewa, Davinder S Jassal
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1532-429X-16-1) contains supplementary material, which is available to authorized users.
Robin A Ducas, Jason E Elliott contributed equally to this work.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

RD, JE, SM, SP, and DJ contributed to the design and enrollment of the study participants. RD, SM, SP, MD, KC, PW, and DJ contributed to the post-processing of the echocardiographic and CMR studies. RD, JE, SM, SP, MD, KC, PW, SM, MH, and DJ contributed to the writing of the manuscript. All authors read and approved the final manuscript.



Cardiovascular disease in pregnancy is the leading cause of maternal mortality in North America. Although transthoracic echocardiography (TTE) is the most widely used imaging modality for the assessment of cardiovascular function during pregnancy, little is known on the role of cardiovascular magnetic resonance (CMR). The objective of the Cardiac Hemodynamic Imaging and Remodeling in Pregnancy (CHIRP) study was to compare TTE and CMR in the non-invasive assessment of maternal cardiac remodeling during the peripartum period.


Between 2010–2012, healthy pregnant women aged 18 to 35 years were prospectively enrolled. All women underwent TTE and CMR during the third trimester and at least 3 months postpartum (surrogate for non-pregnant state).


The study population included a total of 34 women (mean age 29 ± 3 years). During the third trimester, TTE and CMR demonstrated an increase in left ventricular end-diastolic volume from 95 ± 11 mL to 115 ± 14 mL and 98 ± 6 mL to 125 ± 5 mL, respectively (p < 0.05). By TTE and CMR, there was also an increase in left ventricular (LV) mass during pregnancy from 111 ± 10 g to 163 ± 11 g and 121 ± 5 g to 179 ± 5 g, respectively (p < 0.05). Although there was good correlation between both imaging modalities for LV mass, stroke volume, and cardiac output, the values were consistently underestimated by TTE.


This CMR study provides reference values for cardiac indices during normal pregnancy and the postpartum state.
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