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01.01.2020 | Cardio-Oncology (J Mitchell, Section Editor)

Cardiovascular Magnetic Resonance Relaxometry in Early Detection of Anthracycline Cardiotoxicity

verfasst von: Camila Urzua Fresno, Tamar Shalmon, Oscar Calvillo Argüelles, Bernd J. Wintersperger, Paaladinesh Thavendiranathan

Erschienen in: Current Cardiovascular Imaging Reports | Ausgabe 1/2020

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Abstract

Purpose of the Review

To provide an overview of the published data on the value of cardiovascular magnetic resonance (CMR) based T1 and T2 and extracellular volume (ECV) fraction quantification to identify myocardial abnormalities related to anthracycline treatment in patients with cancer.

Recent Findings

In animal models of anthracycline cardiotoxicity, elevations in myocardial T1 and T2 values appear to occur early during treatment followed by ventricular remodeling, persistent elevation in T1, and increase in ECV. These findings suggest early myocardial inflammation/edema followed by myocardial fibrosis and ventricular dysfunction. Similarly in patients receiving cancer therapy, T1 and ECV values increase early after anthracycline therapy. The value of T2 mapping in this setting has not been established. Likewise, adult cancer survivors with or without LV dysfunction have increased ECV values which may be associated with worse diastolic parameters. The value of ECV to identify subclinical cardiomyopathy in pediatric cancer survivors remains controversial.

Summary

Quantitative CMR tissue characterization techniques may have a unique role in identifying the pathophysiology of anthracycline-induced cardiomyopathy and for early detection of myocardial injury. In cancer survivors, these techniques have a potential role in identifying early and subclinical myocardial injury. However, the overall literature on quantitative CMR tissue characterization techniques to detect anthracycline cardiotoxicity is limited.

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Titel: Cardiovascular Magnetic Resonance Relaxometry in Early Detection of Anthracycline Cardiotoxicity
verfasst von: Camila Urzua Fresno
Tamar Shalmon
Oscar Calvillo Argüelles
Bernd J. Wintersperger
Paaladinesh Thavendiranathan
Publikationsdatum: 01.01.2020
Verlag: Springer US
Erschienen in: Current Cardiovascular Imaging Reports / Ausgabe 1/2020
Print ISSN: 1941-9066
Elektronische ISSN: 1941-9074
DOI: https://doi.org/10.1007/s12410-019-9524-2

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Cardiovascular Magnetic Resonance Relaxometry in Early Detection of Anthracycline Cardiotoxicity

Abstract

Purpose of the Review

Recent Findings

Summary

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