Skip to main content
Erschienen in: Current Cardiovascular Imaging Reports 5/2013

01.10.2013 | Invited Commentary

Cardiovascular PET/MR: Potential Role and Challenges

verfasst von: Robert J. Gropler

Erschienen in: Current Cardiovascular Imaging Reports | Ausgabe 5/2013

Einloggen, um Zugang zu erhalten

Excerpt

Recently combined PET/MR hybrid systems have been introduced for human imaging. The technology is based on the premise that combining the relative strengths of the two approaches (Table 1) will result in improved patient management either through better performance of current clinical applications or perhaps the introduction of new applications. In depth summaries on the technical aspects of these systems have been reviewed elsewhere [1, 2]. However in these challenging medical economics times, legitimate questions arise as to whether there is a cardiovascular (CV) role for PET/MR and if so, what is pathway to clinical implementation? Described below are a few thoughts in support of such a role for CV PET/MR and on the challenges in performing it and moving it the clinic.
Table 1
Relative strengths and weaknesses of PET and MR
 
PET
MR
Sensitivity
10-11-10-12 mol/L
10-3-10-5 mol/L
Spatial resolution
1-2 mm
50-250 μm
Temporal resolution
Modest
High
Characterization of anatomy & function
Yes but limited
Comprehensive
Coronary angiography
No
Yes
Tissue characterization
Limited to PET Probes Used
Diverse
Whole-heart coverage
Yes
Yes but not for all applications
Need for intravenous contrast
No
Yes
Ionizing radiation exposure
Yes
No
Literatur
1.
Zurück zum Zitat Rischpler C, Nekolla SG, Dregely I, Schwaiger M. Hybrid PET/MR imaging of the heart: potential, initial experiences, and future prospects. J Nucl Med. 2013;54:402–15.PubMedCrossRef Rischpler C, Nekolla SG, Dregely I, Schwaiger M. Hybrid PET/MR imaging of the heart: potential, initial experiences, and future prospects. J Nucl Med. 2013;54:402–15.PubMedCrossRef
2.
Zurück zum Zitat Catana C, Guimaries AR, Rosen BR. PET and MR imaging: the odd couple or amtch made in heaven. J Nucl Med. 2013;54:815–24.PubMedCrossRef Catana C, Guimaries AR, Rosen BR. PET and MR imaging: the odd couple or amtch made in heaven. J Nucl Med. 2013;54:815–24.PubMedCrossRef
3.
Zurück zum Zitat Gaemperli O, Saraste A, Knuuti J. Cardiac hybrid imaging. Eur Heart J Cardiovasc Imaging. 2012;13:51–60.PubMedCrossRef Gaemperli O, Saraste A, Knuuti J. Cardiac hybrid imaging. Eur Heart J Cardiovasc Imaging. 2012;13:51–60.PubMedCrossRef
4.
Zurück zum Zitat Pazhenkottil AP, Nkoulou RN, Ghadri JR, Herzog BA, Buechel RR, Küest SM, et al. Prognostic value of cardiac hybrid imaging integrating single-photon emission computed tomography with coronary computed tomography angiography. Eur Heart J. 2011;32:1465–71.PubMedCrossRef Pazhenkottil AP, Nkoulou RN, Ghadri JR, Herzog BA, Buechel RR, Küest SM, et al. Prognostic value of cardiac hybrid imaging integrating single-photon emission computed tomography with coronary computed tomography angiography. Eur Heart J. 2011;32:1465–71.PubMedCrossRef
5.
Zurück zum Zitat Ohira H, Tsujino I, Ishimaru S, Oyama N, Takei T, Tsukamoto E, et al. Eur Myocardial imaging with 18F-fluoro-2-deoxyglucose positron emission tomography and magnetic resonance imaging in sarcoidosis. J Nucl Med Mol Imaging. 2008;35:933–41.CrossRef Ohira H, Tsujino I, Ishimaru S, Oyama N, Takei T, Tsukamoto E, et al. Eur Myocardial imaging with 18F-fluoro-2-deoxyglucose positron emission tomography and magnetic resonance imaging in sarcoidosis. J Nucl Med Mol Imaging. 2008;35:933–41.CrossRef
6.
Zurück zum Zitat Berker Y, Franke J, Salomon A, Palmowski M, Donker HC, Temur Y, et al. MRI-based attenuation correction for hybrid PET/MRI systems: a 4-class tissue segmentation technique using a combined ultrashort-echo-time/Dixon MRI sequence. J Nucl Med. 2012;53:796–804.PubMedCrossRef Berker Y, Franke J, Salomon A, Palmowski M, Donker HC, Temur Y, et al. MRI-based attenuation correction for hybrid PET/MRI systems: a 4-class tissue segmentation technique using a combined ultrashort-echo-time/Dixon MRI sequence. J Nucl Med. 2012;53:796–804.PubMedCrossRef
7.
Zurück zum Zitat Yu J, Schär M, Vonken EJ, Kelle S, Stuber M. Improved SNR efficiency in gradient echo coronary MRA with high temporal resolution using parallel imaging. Magn Reson Med. 2009;62:1211–20.PubMedCrossRef Yu J, Schär M, Vonken EJ, Kelle S, Stuber M. Improved SNR efficiency in gradient echo coronary MRA with high temporal resolution using parallel imaging. Magn Reson Med. 2009;62:1211–20.PubMedCrossRef
8.
Zurück zum Zitat Prompona M, Cyran C, Nikolaou K, Bauner K, Reiser M, Huber A. Contrast-enhanced whole-heart coronary MRA using Gadofosveset 3.0 T versus 1.5 T. Acad Radiol. 2010;17:862–70.PubMedCrossRef Prompona M, Cyran C, Nikolaou K, Bauner K, Reiser M, Huber A. Contrast-enhanced whole-heart coronary MRA using Gadofosveset 3.0 T versus 1.5 T. Acad Radiol. 2010;17:862–70.PubMedCrossRef
Metadaten
Titel
Cardiovascular PET/MR: Potential Role and Challenges
verfasst von
Robert J. Gropler
Publikationsdatum
01.10.2013
Verlag
Springer US
Erschienen in
Current Cardiovascular Imaging Reports / Ausgabe 5/2013
Print ISSN: 1941-9066
Elektronische ISSN: 1941-9074
DOI
https://doi.org/10.1007/s12410-013-9221-5

Weitere Artikel der Ausgabe 5/2013

Current Cardiovascular Imaging Reports 5/2013 Zur Ausgabe

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.