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Current Cardiology Reports
Erschienen in: Current Cardiology Reports 7/2017

01.07.2017 | Cardio-Oncology (SA Francis, Section Editor)

Cardiovascular Risk in Survivors of Cancer

verfasst von: Henry Chen Zheng, Laura Onderko, Sanjeev A. Francis

Erschienen in: Current Cardiology Reports | Ausgabe 7/2017

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Abstract

Purpose of Review

Survivors of childhood and adult cancers face increased risk of cardiovascular disease. We review the current evidence base and guidelines for this rapidly growing population.

Recent Findings

Research continues to show that cardiovascular disease is an important cause of morbidity and mortality in cancer survivors. Cardiotoxicity related to chemotherapy and radiotherapy accounts for part of this increased risk. There is emerging evidence that cancer and cardiovascular disease share a similar biology and risk factors.

Summary

At present, there are several guidelines and consensus recommendations for the management of cardiovascular risk in cancer survivors. The evidence base is accumulating though additional research is necessary to demonstrate improved outcomes and comparative effectiveness.
Literatur
1.
2.
3.
4.
5.
•• Moslehi JJ. Cardiovascular toxic effects of targeted cancer therapies. Longo DL, ed. N Engl J Med. 2016;375(15):1457–1467. doi:10.​1056/​NEJMra1100265. This review provides a comprehensive overview of cardiovascular toxicity due to novel targeted cancer therapies.
6.
7.
Hahn VS, Lenihan DJ, Ky B. Cancer therapy–induced cardiotoxicity: basic mechanisms and potential cardioprotective therapies. J Am Heart Assoc. 2014;3(2):–e000665. doi:10.​1161/​JAHA.​113.​000665.
8.
9.
10.
Mulrooney DA, Yeazel MW, Kawashima T, et al. Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the childhood cancer survivor study cohort. BMJ. 2009;339(dec08 1):b4606. doi:10.​1136/​bmj.​b4606.CrossRefPubMedPubMedCentral
11.
12.
Galper SL, Yu JB, Mauch PM, et al. Clinically significant cardiac disease in patients with Hodgkin lymphoma treated with mediastinal irradiation. Blood. 2011;117(2):412–8.CrossRefPubMed
13.
Heidenreich PA, Hancock SL, Lee BK, Mariscal CS, Schnittger I. Asymptomatic cardiac disease following mediastinal irradiation. J Am Coll Cardiol. 2003;42(4):743–9.CrossRefPubMed
14.
Hull MC, Morris CG, Pepine CJ, Mendenhall NP. Valvular dysfunction and carotid, subclavian, and coronary artery disease in survivors of Hodgkin lymphoma treated with radiation therapy. JAMA. 2003;290(21):2831–7.CrossRefPubMed
15.
•• Lancellotti P, Nkomo VT, Badano LP, et al. Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. J Am Soc Echocardiogr. 2013;26(9):1013–32. doi:10.​1016/​j.​echo.​2013.​07.​005. This expert consensus document provides a nice review of radiation-associated heart disease as well as practical guidelines for the practicing clinician. CrossRefPubMed
16.
Groarke JD, Nguyen PL, Nohria A, Ferrari R, Cheng S, Moslehi J. Cardiovascular complications of radiation therapy for thoracic malignancies: the role for non-invasive imaging for detection of cardiovascular disease. Eur Heart J. 2014;35(10):612–23. doi:10.​1093/​eurheartj/​eht114.CrossRefPubMed
17.
18.
19.
Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med. 2005;353:1673–84.CrossRefPubMed
20.
Suter TM, Procter M, van Veldhuisen DJ, et al. Trastuzumab-associated cardiac adverse effects in the herceptin adjuvant trial. J Clin Oncol. 2007;25:3859–65.CrossRefPubMed
21.
22.
Lenihan DJ, Oliva S, Chow EJ, Cardinale D. Cardiac toxicity in cancer survivors. Cancer. 2013;119(Suppl 11):2131–42.CrossRefPubMed
23.
Curigliano G, Cardinale D, Suter T, et al. Cardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy: ESMO clinical practice guidelines. Annals of oncology : official journal of the European Society for Medical Oncology. 2012;23(Suppl 7):vii155–66.CrossRef
24.
Hunt SA, Abraham WT, Chin MH, et al. Focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation. 2009;119(14):e391–479.CrossRefPubMed
25.
Cardinale D, Colombo A, Lamantia G, et al. Anthracycline-induced cardiomyopathy: clinical relevance and response to pharmacologic therapy. J Am Coll Cardiol. 2010;55(3):213–20.CrossRefPubMed
26.
Groarke JD, Nohria A. Anthracycline cardiotoxicity: a new paradigm for an old classic. Circulation. 2015;131(22):1946–9.CrossRefPubMed
27.
Silber JH, Cnaan A, Clark BJ, et al. Enalapril to prevent cardiac function decline in long-term survivors of pediatric cancer exposed to anthracyclines. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2004;22(5):820–8.CrossRef
28.
National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology. Survivorship Guidelines. Version 2. 2016.
29.
•• Plana JC, Galderisi M, Barac A, et al. Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. 2014;27(9):911–39. This expert consensus provides a nice review of chemotherapy-associated heart disease and provides practical guidelines for the practicing clinician particularly in regard to the role of cardiac imaging in the screening, diagnosis, and follow-up of patients with cardiotoxicity. CrossRef
30.
31.
van der Pal HJ, van Dalen EC, van Delden E, et al. High risk of symptomatic cardiac events in childhood cancer survivors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2012;30(13):1429–37.CrossRef
32.
Franco VI, Lipshultz SE. Cardiac complications in childhood cancer survivors treated with anthracyclines. Cardiol Young. 2015;25(Suppl 2):107–16.CrossRefPubMed
33.
Children’s Oncology Grop. Long-term follow-up guidelines for survivors of childhood, adolescent and young adult cancers Version 4.0. 2013.
34.
Sieswerda E, Postma A, van Dalen EC, et al. The Dutch Childhood Oncology Group guideline for follow-up of asymptomatic cardiac dysfunction in childhood cancer survivors. Annals of oncology : official journal of the European Society for Medical Oncology. 2012;23(8):2191–8.CrossRef
35.
Wallace WH, Thompson L, Anderson RA, Guideline Development G. Long term follow-up of survivors of childhood cancer: summary of updated SIGN guidance. BMJ. 2013;346:f1190.CrossRefPubMed
36.
United Kingdon Children’s Cancer Study Late Effects Group. Therapy based long term follow up practice statement. 2005.
37.
Wong FL, Bhatia S, Landier W, et al. Cost-effectiveness of the children’s oncology group long-term follow-up screening guidelines for childhood cancer survivors at risk for treatment-related heart failure. Ann Intern Med. 2014;160(10):672–83.CrossRefPubMedPubMedCentral
38.
Yeh JM, Nohria A, Diller L. Routine echocardiography screening for asymptomatic left ventricular dysfunction in childhood cancer survivors: a model-based estimation of the clinical and economic effects. Ann Intern Med. 2014;160(10):661–71.CrossRefPubMedPubMedCentral
39.
Kremer LC, Mulder RL, Oeffinger KC, et al. A worldwide collaboration to harmonize guidelines for the long-term follow-up of childhood and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group. Pediatr Blood Cancer. 2013;60(4):543–9.CrossRefPubMed
40.
Steingart RM, Liu JE, Oeffinger KC. Cost-effectiveness of screening for asymptomatic left ventricular dysfunction in childhood cancer survivors. Ann Intern Med. 2014;160(10):731–2.CrossRefPubMed
41.
Ward E, DeSantis C, Robbins A, Kohler B, Jemal A. Childhood and adolescent cancer statistics, 2014. CA Cancer J Clin. 2014;64(2):83–103.CrossRefPubMed
42.
Dickerman JD. The late effects of childhood cancer therapy. Pediatrics. 2007;119(3):554–68.CrossRefPubMed
43.
Nathan PC, Hayes-Lattin B, Sisler JJ, Hudson MM. Critical issues in transition and survivorship for adolescents and young adults with cancers. Cancer. 2011;117(10 Suppl):2335–41.CrossRefPubMed
44.
Iyer NS, Mitchell HR, Zheng DJ, Ross WL, Kadan-Lottick NS. Experiences with the survivorship care plan in primary care providers of childhood cancer survivors: a mixed methods approach. Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer. 2017 May;25(5):1547–55. doi:10.​1007/​s00520-016-3544-0. Epub 2017 Jan 3.
45.
Reppucci ML, Schleien CL, Fish JD. Looking for trouble: adherence to late-effects surveillance among childhood cancer survivors. Pediatr Blood Cancer. 2017;64(2):353–7.CrossRefPubMed
46.
Mertens AC, Cotter KL, Foster BM, et al. Improving health care for adult survivors of childhood cancer: recommendations from a delphi panel of health policy experts. Health policy (Amsterdam, Netherlands). 2004;69(2):169–78.CrossRef
47.
Zebrack BJ, Eshelman DA, Hudson MM, et al. Health care for childhood cancer survivors: insights and perspectives from a Delphi panel of young adult survivors of childhood cancer. Cancer. 2004;100(4):843–50.CrossRefPubMed
48.
Nathan PC, Greenberg ML, Ness KK, et al. Medical care in long-term survivors of childhood cancer: a report from the childhood cancer survivor study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2008;26(27):4401–9.CrossRef
49.
Metadaten
Titel
Cardiovascular Risk in Survivors of Cancer
verfasst von
Henry Chen Zheng
Laura Onderko
Sanjeev A. Francis
Publikationsdatum
01.07.2017
Verlag
Springer US
Erschienen in
Current Cardiology Reports / Ausgabe 7/2017
Print ISSN: 1523-3782
Elektronische ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-017-0873-7

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