Carotid stiffness and atherosclerotic risk: non-invasive quantification with ultrafast ultrasound pulse wave velocity | springermedizin.de

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European Radiology

Erschienen in:

05.09.2018 | Ultrasound

Carotid stiffness and atherosclerotic risk: non-invasive quantification with ultrafast ultrasound pulse wave velocity

verfasst von: Zheng-Qiu Zhu, Ling-Shan Chen, Han Wang, Fu-Ming Liu, Yun Luan, Lin-Lin Wu, Niu Liu, Pin Wang, Hui Huang

Erschienen in: European Radiology | Ausgabe 3/2019

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Abstract

Objectives

To evaluate the value of ultrafast pulse wave velocity (ufPWV) for the quantitative assessment of carotid stiffness and its associated with atherosclerosis (AS) risk.

Methods

The present study included 233 patients with hyperlipoidaemia (AS risk group) and 114 healthy adults as the control group. The carotid (n = 694) intima-media thickness (cIMT), pulse wave velocity-beginning of systole (PWV-BS) and pulse wave velocity-end of systole (PWV-ES) were measured on sample images. Differences, distributive characteristics and correlation evaluation were assessed in patients (ages 18–29, 30–39, 40–49, 50–59, 60–69 and ≥70) and carotids (control group vs AS risk group).

Results

The cIMT, PWV-BS and PWV-ES increased with age; PWV-ES and cIMT showed an early significant increase in the 30–39 years group, whereas PWV-BS displayed a significant increase at 40–49 years compared with the 18- to 29-years group. Besides, PWV-ES correlated well with age compared with PWV-BS and cIMT. For carotid level, cIMT, PWV-BS and PWV-ES measurements were higher in the AS risk group compared with control. To compare the value of ufPWV and cIMT in early AS assessment, we subdivided groups into cIMT subgroups using a cut-off thickness of 0.050 cm. PWV-ES measurements were higher in the AS risk group compared with the control in the 0.040–0.050 cm (not thickened) and 0.051–0.060 cm (thickened) cIMT subgroups.

Conclusions

Carotid ufPWV measurement at PWV-ES is a novel modality for the early diagnosis and quantitative assessment of arterial stiffness associated with atherosclerotic risk.

Key Points

• ufPWV technique is real-time and well repeatable for assessing carotid stiffness

• ufPWV measurements increase and correlate well with age

• PWV-ES is a quantitative predictor for the early assessment of AS

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Titel: Carotid stiffness and atherosclerotic risk: non-invasive quantification with ultrafast ultrasound pulse wave velocity
verfasst von: Zheng-Qiu Zhu
Ling-Shan Chen
Han Wang
Fu-Ming Liu
Yun Luan
Lin-Lin Wu
Niu Liu
Pin Wang
Hui Huang
Publikationsdatum: 05.09.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 3/2019
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-018-5705-7

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