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01.12.2017 | Case report | Ausgabe 1/2017 Open Access

BMC Nephrology 1/2017

Case report - atypical hemolytic uremic syndrome triggered by influenza B

Zeitschrift:
BMC Nephrology > Ausgabe 1/2017
Autoren:
Robin Kobbe, Raphael Schild, Martin Christner, Jun Oh, Sebastian Loos, Markus J. Kemper

Abstract

Background

Influenza A infections have been described to cause secondary hemolytic uremic syndrome and to trigger atypical hemolytic uremic syndrome (aHUS) in individuals with an underlying genetic complement dysregulation. To date, influenza B has not been reported to trigger aHUS.

Case presentation

A 6-month-old boy presented with hemolytic uremic syndrome triggered by influenza B infection. Initially the child recovered spontaneously. When he relapsed Eculizumab treatment was initiated, resulting in complete and sustained remission. A pathogenic mutation in membrane cofactor protein (MCP) was detected.

Conclusion

Influenza B is a trigger for aHUS and might be underreported as such. Influenza vaccination may protect patients at risk.
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