The online version of this article (doi:10.1186/1477-7819-10-91) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
WFSJ performed critical appraisal of the literature and wrote the manuscript. MTCC supervised, assisted in the critical appraisal of the included studies and editing of the manuscript. Both authors contributed to the final proof-reading of the manuscript.
This is a case of metastatic lung cancer of the lymphoepithelial-like carcinoma (LELC) variant who first presented with symptomatic brain metastasis. The patient underwent local and systemic treatment for metastatic disease with good clinical outcome. The patient was disease free for four years then she had primary lung recurrence which was surgically resected. She underwent a second course of chemotherapy with saw her through another two years of disease free period. A recurrence of the cancer was detected intra-abdominally on the seventh year of diagnosis. This was treated again with surgical resection and another course of chemotherapy.
Authors’ original file for figure 112957_2011_1012_MOESM1_ESM.pdf
Authors’ original file for figure 212957_2011_1012_MOESM2_ESM.pdf
Authors’ original file for figure 312957_2011_1012_MOESM3_ESM.pdf
Authors’ original file for figure 412957_2011_1012_MOESM4_ESM.pdf
Authors’ original file for figure 512957_2011_1012_MOESM5_ESM.pdf
Williamson SR, Zhang S, Lopez-Beltran A, Shah RB, Montironi R, Tan PH, Wang M, Baldridge LA, MacLennan GT, Cheng L: Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. Am J Surg Pathol. 2011, 35 (4): 474-483. 10.1097/PAS.0b013e31820f709e. CrossRefPubMed
Blasi MA, Ventura L, Laguardia M, Tiberti AC, Sammarco MG, Balestrazzi E: Lymphoepithelioma-like carcinoma involving the lacrimal gland and infiltrating the eyelids. Eur J Ophthalmol. 2010, 21 (3): 320-323. CrossRef
Brun Jean-Luc MD, Randriambelomanana , Joseph MD: Cher International Journal of Gynecological Pathology: Pathology of the Upper Genital Tract: Case Reports - Lymphoepithelioma-like Carcinoma of the Ovary. A Case Report and Review of the Literature. 2010, 29 (5): 427-431.
Tseng CJ, Pao CC, Tseng LH, Chang CT, Lai CH, Soong YK, Hsueh S, Jyu-Jen H: Lymphoepithelioma-like carcinoma of the uterine cervix: association with Epstein-Barr virus and human papillomavirus. Cancer. 1997, 80 (1): 91-97. 10.1002/(SICI)1097-0142(19970701)80:1<91::AID-CNCR12>3.0.CO;2-A. CrossRefPubMed
Higashiyama M, Doi O, Kodama K: Lymphoepithelioma-like carcinoma of lungs: Analysis of 2 cases for Epstein-Barr virus infection. Human Pathol. 1995, 26: 1278-1282. 10.1016/0046-8177(95)90206-6. CrossRef
Iezzoni JC, Gaffey MJ, Weiss LM: The role of Epstein-Barr virus in lymphoepithelioma-like carcinoma of the lung. Cancer. 1995, 76: 413-422. 10.1002/1097-0142(19950801)76:3<413::AID-CNCR2820760311>3.0.CO;2-X. CrossRef
Hessel PA, Gamble JF, Gee JB: Silica, silicosis and lung cancer : a response to a recent working group report. J Occup Environ Med. 2000, 704-720.
Pairon JC, Brochard P, Jaurand MC, Bignon J: Silica and lung cancer: a controversial issue. Eur Respir J. 1991, 4: 730-744. PubMed
NIOSH Hazard Review Health effects of Occupational exposure to Respirable Crystalline Silica. Department of Health and Human Services. National Institute for Occupational Safety and Health.April 2002:
Hoxworth JM: et al. Lymphoepithelioma-like carcinoma of the Lung: Radiologic Features of an uncommon primary pulmonary neoplasm. AJR: 186 May 2006:
Ooi C, Ho M, Khong L, Wong P, Lam K, Tsang T: Computed tomography characteristics of advanced primary pulmonary lympheepithelioma-like carcinoma. Eur Radiol. 2003, 13: 522-526. PubMed
Yi Chin A: Tissue Characterization of Solitary Pulmonary Nodule: Comparative Study Between Helical Dynamic CT and Integrated PET/CT. The J of Nucl Med. 2006, 47: 443-450.
Cappabianca S: Preliminary study on the correlation between grading and histology of solitary pulmonary nodules and contrast enhancement and [18F]fluorodeoxyglucose standardized uptake value after evaluation by dynamic multiphase CT and PET/CT. 2012, group.bmj.com
Cheng CS, Yeung WH, Kwok WK, Kwan WH: Lymphoepithelial-like Carcinoma of the Lung. J HK Coll Radiol. 2002, 5: 47-49. CrossRef
NCCN clinical practice guidelines in oncology NSCLC. V3.2011. National Comprehensive Cancer Network ®
Chen FF, Yan JJ, Lai WW, Jin YT, Su IJ: Epstein-Barr virus-associated nonsmall cell lung carcinoma: undifferentiated “lymphoepithelioma-like” carcinoma as a distinct entity with better prognosis. Cancer. 1998, 82 (12): 2334-2342. 10.1002/(SICI)1097-0142(19980615)82:12<2334::AID-CNCR6>3.0.CO;2-S. CrossRefPubMed
- Case report: lymphoepithelial-like carcinoma of the lung-a chronic disease?
Joelle FS Wong
Melissa CC Teo
- BioMed Central
Neu im Fachgebiet Chirurgie
Mail Icon II