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Journal of Natural Medicines
Erschienen in:

14.11.2024 | Original Paper

Cathagines A–D, new bisindole alkaloids from Catharanthus roseus

verfasst von: Yusuke Hirasawa, Chiaki Kasagi, Erika Koyama, Hitomi Myojin, Takahiro Tougan, Toshihiro Horii, Nahoko Uchiyama, Toshio Kaneda, Hiroshi Morita

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2025

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Abstract

Four new bisindole alkaloids, cathagines A (1)–D (4) consisting of an aspidosperma and the fused tetracyclic 3-spirooxindole derived from an iboga type skeleton were isolated from the whole plant of Catharanthus roseus. The structures including absolute stereochemistry were elucidated on the basis of 2D NMR data and CD spectra. Cathagine B (2) showed moderate anti-malarial activity against Plasmodium falciparum 3D7.

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Metadaten
Titel
Cathagines A–D, new bisindole alkaloids from Catharanthus roseus
verfasst von
Yusuke Hirasawa
Chiaki Kasagi
Erika Koyama
Hitomi Myojin
Takahiro Tougan
Toshihiro Horii
Nahoko Uchiyama
Toshio Kaneda
Hiroshi Morita
Publikationsdatum
14.11.2024
Verlag
Springer Nature Singapore
Erschienen in
Journal of Natural Medicines / Ausgabe 1/2025
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-024-01857-4

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