Background
Methods
Data collection
Study population
AKI and Baesline creatinine definition
AKI Stage | Serum Creatinine (SCr) Criteria |
---|---|
1 | Increase > 26.4 μmol/L (0.3 mg/dL) or 1.5–1.9 times baseline |
2 | Increase 2.0–2.9 times baseline |
3 | Increase creatinine > 354 μmol/L (4.0 mg/dL) or 3 times baseline |
AKI risk factors
Feature Category | # of Variable | Details |
---|---|---|
Demographics | 3 | Age, gender, race |
Vitals | 5 | BMI, diastolic BP, systolic BP, pulse, temperature |
Lab Tests | 14 | Albumin, ALT, AST, Ammonia, Blood Bilirubin, BUN, Ca, CK-MB, CK, Glucose, Lipase, Platelets, Troponin, WBC |
Comorbidities | 28 | UHC comorbidity |
Admission Diagnosis | 129 | UHC APR-DRG |
Medications | 482 | All medications are mapped to RxNorm ingredient |
Medical History | 230 | ICD9 codes mapped to CCS major diagnoses |
Vitals | Categories |
---|---|
BMI | < 18.5, [18.5–24.9], [25.0–29.9], > 30.0, Unknown |
Diastolic BP | < 80, [80–89], [90–99], > 100, Unknown |
Systolic BP | < 120, [120–139], [140–159], > 160, Unknown |
Pulse | < 50, [50–65], [66–80], [81–100], > 100, Unknown |
Temperature | < 95.0, [95.0–97.6], [97.7–99.5], [99.5–104.0], > 104.0, Unknown |
Experimental methodology
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Results
Causal risk factor discovery
Combinations of risk factors | Risk factors | Odd Ratio [95% CI] | |||
---|---|---|---|---|---|
#1 | #2 | #3 | #4 | ||
CoRF1 | 1 | 0 | 0 | 0 | 1.24 [0.69, 2.23] |
CoRF2 | 0 | 1 | 0 | 0 | 1.47 [0.92, 2.34] |
CoRF3 | 0 | 0 | 1 | 0 | 0.64 [0.26, 1.56] |
CoRF4 | 0 | 0 | 0 | 1 | 0.66 [0.37, 1.19] |
CoRF5 | 1 | 0 | 0 | 1 | 0.62 [0.30, 1.25] |
CoRF6 | 1 | 0 | 1 | 0 | 0.48 [0.18, 1.29] |
CoRF7 | 1 | 1 | 0 | 0 | 1.56 [0.90, 2.70] |
CoRF8 | 0 | 1 | 0 | 1 | 1.48 [0.97, 2.26] |
CoRF9 | 0 | 1 | 1 | 0 | 1.24 [0.67, 2.28] |
CoRF10 | 0 | 0 | 1 | 1 | 0.30 [0.04, 2.12] |
CoRF11 | 1 | 0 | 1 | 1 | 0.28 [0.04, 1.97] |
CoRF12 | 1 | 1 | 0 | 1 | 0.94 [0.58, 1.53] |
CoRF13 | 1 | 1 | 1 | 0 | 0.92 [0.52, 1.62] |
CoRF14 | 0 | 1 | 1 | 1 | 1.20 [0.53, 2.72] |
CoRF15 | 1 | 1 | 1 | 1 | 1.18 [0.66, 2.12] |
Stage-3 AKI risk prediction
Models (# of variable) | AUC | F-score | Recall | Precision |
---|---|---|---|---|
McDSL (4) | 0.812 | 0.753 | 0.761 | 0.743 |
McDSL + PLoS one (6) | 0.814 | 0.748 | 0.744 | 0.738 |
LR (88) | 0.837 | 0.775 | 0.810 | 0.734 |