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01.07.2016 | Review

Caveolin-1/-3: therapeutic targets for myocardial ischemia/reperfusion injury

verfasst von: Yang Yang, Zhiqiang Ma, Wei Hu, Dongjin Wang, Shuai Jiang, Chongxi Fan, Shouyin Di, Dong Liu, Yang Sun, Wei Yi

Erschienen in: Basic Research in Cardiology | Ausgabe 4/2016

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Abstract

Myocardial ischemia/reperfusion (I/R) injury is a major cause of morbidity and mortality worldwide. Caveolae, caveolin-1 (Cav-1), and caveolin-3 (Cav-3) are essential for the protective effects of conditioning against myocardial I/R injury. Caveolins are membrane-bound scaffolding proteins that compartmentalize and modulate signal transduction. In this review, we introduce caveolae and caveolins and briefly describe the interactions of caveolins in the cardiovascular diseases. We also review the roles of Cav-1/-3 in protection against myocardial ischemia and I/R injury, and in conditioning. Finally, we suggest several potential research avenues that may be of interest to clinicians and basic scientists. The information included, herein, is potentially useful for the design of future studies and should advance the investigation of caveolins as therapeutic targets.

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Titel: Caveolin-1/-3: therapeutic targets for myocardial ischemia/reperfusion injury
verfasst von: Yang Yang
Zhiqiang Ma
Wei Hu
Dongjin Wang
Shuai Jiang
Chongxi Fan
Shouyin Di
Dong Liu
Yang Sun
Wei Yi
Publikationsdatum: 01.07.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Basic Research in Cardiology / Ausgabe 4/2016
Print ISSN: 0300-8428
Elektronische ISSN: 1435-1803
DOI: https://doi.org/10.1007/s00395-016-0561-6

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Caveolin-1/-3: therapeutic targets for myocardial ischemia/reperfusion injury

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