Background
Methods
DNA microarray
Antibodies
Tissue microarray
Immunohistochemistry
Statistical analyses
Results
DNA microarray
Immunohistochemistry
BC-1514 (C15) | BC-1514 (W12) | CAMK2N1 | CD1d | PJA2 | |
---|---|---|---|---|---|
ICMF | 200 (218.5, 200–300) | 200 (243.6, 200–300) | 200 (192.1, 200–200) | 80 (90.6, 35–170) | 100 (134.5, 90–200) |
ICNMF | 180 (139.1, 90–200) | 200 (210.9, 180–300) | 90 (83.0, 80–100) | 95 (114.1, 80–190) | 200 (164.3, 100–200) |
p
| < 0.001* | 0.001* | < 0.001* | 0.006* | 0.002* |
RPL5 | SAMD13 | TCF4 | TXNIP | ||
ICMF | 300 (233.4, 300–300) | 90 (95.8, 60–100) | 200 (241.5, 200–300) | 100 (126.9, 80–200) | |
ICNMF | 40 (58.9, 10–90) | 80 (67.3, 10–90) | 200 (219.2, 200–300) | 90 (114.4, 80–190) | |
p
| < 0.001* | < 0.001* | 0.014* | 0.109 |
Parameter | Cases (percentage) | BC-1514 (C15) | P value | BC-1514 (W12) | P value | CD1d | P value | PJA2 | P value | |
---|---|---|---|---|---|---|---|---|---|---|
Age | ||||||||||
< 55 | 115 (39.1) | 180 (160.7, 90–200) | 0.903 | 200 (212.4, 200–300) | 0.245 | 90 (98.2, 60–180) | 0.182 | 180 (157.3, 90–200) | 0.956 | |
≥ 55 | 179 (60.9) | 180 (162.5, 100–200) | 200 (225.7, 200–300) | 95 (113.8, 60–180) | 180 (155.5, 90–200) | |||||
pT | ||||||||||
I-II | 281 (95.6) | 180 (161.1, 90–200) | 0.368 | 200 (218.2, 200–300) | 0.015* | 90 (108.1, 60–180) | 0.413 | 180 (155.9, 90–200) | 0.445 | |
III-IV | 13 (4.4) | 200 (177.5, 100–300) | 300 (266.7, 200–300) | 90 (100.0, 10–180) | 200 (163.8, 100–200) | |||||
pN | ||||||||||
pN0 | 192 (65.3) | 180 (163.9, 90–200) | 0.709 | 200 (221.6, 200–300) | 0.979 | 90 (109.8, 70–190) | 0.466 | 180 (157.3, 90–200) | 0.99 | |
pN1 or above | 102 (34.7) | 180 (157.9, 95–200) | 200 (218.9, 200–300) | 90 (103.9, 40–180) | 180 (154.1, 90–200) | |||||
Distant metastasis | ||||||||||
M0 | 289 (98.3) | 180 (160.5, 90–200) | 0.121 | 200 (219.4, 200–300) | 0.09 | 90 (108.1, 60–180) | 0.696 | 180 (155.8, 90–200) | 0.222 | |
M1 | 5 (1.7) | 250 (215.0, 105–300) | 300 (266.7, 200–300) | 90 (92.0, 45–135) | 200 (180.0, 150–200) | |||||
pStage | ||||||||||
I-II | 247 (84.0) | 180 (161.5, 90–200) | 0.525 | 200 (220.1, 200–300) | 0.448 | 90 (107.2, 60–180) | 0.868 | 180 (155.3, 90–200) | 0.416 | |
III-IV | 47 (16.0) | 200 (162.9, 100–200) | 200 (222.5, 200–300) | 90 (110.7, 50–190) | 200 (161.0, 100–200) | |||||
Histological grade | ||||||||||
1 or 2 | 230 (78.2) | 180 (158.7, 90–200) | 0.176 | 200 (214.1, 200–300) | 0.009* | 90 (107.4, 60–180) | 0.832 | 180 (158.2, 95–200) | 0.498 | |
3 | 64 (21.8) | 200 (172.6, 100–200) | 200 (242.4, 200–300) | 95 (109.2, 60–180) | 180 (149.1, 90–200) | |||||
Lymphatic vessel invasion | ||||||||||
absent | 128 (43.5) | 180 (156.1, 90–200) | 0.105 | 200 (218.8, 200–300) | 0.782 | 90 (110.8, 70–190) | 0.524 | 180 (156.4, 90–200) | 0.69 | |
present | 166 (56.5) | 200 (166.3, 100–200) | 200 (221.8, 200–300) | 90 (105.4, 50–180) | 180 (156.1, 100–200) | |||||
Blood vessel invasion | ||||||||||
absent | 243 (82.7) | 180 (163.4, 100–200) | 0.57 | 200 (220.4, 200–300) | 0.895 | 90 (108.4, 60–180) | 0.836 | 180 (157.5, 90–200) | 0.543 | |
present | 51 (17.3) | 180 (154.3, 90–200) | 200 (220.9, 200–300) | 90 (104.7, 55–145) | 180 (150.0, 100–200) | |||||
ER | ||||||||||
negative | 48 (16.3) | 200 (157.4, 90–200) | 0.97 | 200 (241.7, 200–300) | 0.066 | 95 (121.7, 90–180) | 0.127 | 200 (165.9, 95–200) | 0.226 | |
positive | 246 (83.7) | 180 (162.5, 100–200) | 200 (217.1, 200–300) | 90 (104.9, 60–180) | 180 (154.3, 90–200) | |||||
PgR | ||||||||||
negative | 96 (32.7) | 180 (167.2, 90–200) | 0.605 | 200 (229.5, 200–300) | 0.208 | 90 (110.9, 60–180) | 0.632 | 200 (164.4, 97.5–200) | 0.105 | |
positive | 198 (67.3) | 180 (159.5, 100–200) | 200 (216.7, 200–300) | 90 (106.3, 60–190) | 180 (152.4, 90–200) | |||||
HER2 | ||||||||||
negative | 247 (85.2) | 180 (160.1, 90–200) | 0.161 | 200 (216.8, 200–300) | 0.043* | 90 (108.2, 65–190) | 0.471 | 180 (154.4, 90–200) | 0.207 | |
positive | 43 (14.8) | 200 (176.0, 100–200) | 300 (247.6, 200–300) | 92.5 (108.3, 40–180) | 180 (162.4, 95–200) | |||||
Ki-67 | ||||||||||
< 14 | 68 (23.1) | 160 (136.8, 90–200) | 0.010* | 200 (196.7, 180–250) | 0.011* | 90 (91.7, 55–92.5) | 0.036* | 180 (150.8, 90–200) | 0.603 | |
≥ 14 | 205 (69.7) | 180 (158.9, 95–200) | 200 (225.1, 200–300) | 95 (112.8, 60–190) | 180 (159.5, 90–200) | |||||
Triple negative | ||||||||||
no | 263 (89.5) | 180 (164.4, 100–200) | 0.095 | 200 (219.4, 200–300) | 0.434 | 90 (106.3, 60–180) | 0.106 | 180 (154.9, 90–200) | 0.199 | |
yes | 31 (10.5) | 120 (135.8, 70–200) | 200 (231.2, 200–300) | 97.5 (121.5, 90–190) | 200 (167.8, 90–200) |
Survival analyses
Disease free survival | Overall survival | ||||
---|---|---|---|---|---|
Parameter | Criteria |
p
| HR (95% CI) |
p
| HR (95% CI) |
Age | < 55 vs. 55 or more | 0.556 | 0.803 (0.386–1.669) | 0.322 | 0.594 (0.212–1.667) |
pT | I-II vs. III-IV | 0.001* | 6.135 (2.123–17.86) | < 0.001* | 9.090 (3.247–25.64) |
pN | 0 vs. 1–3 | < 0.001* | 4.950 (2.252–10.87) | 0.004* | 4.150 (1.560–11.11) |
pStage | I-II vs. III-IV | 0.011* | 2.793 (1.267–6.135) | < 0.001* | 5.587 (2.212–14.08) |
Histological grade | 1/2 vs. 3 | 0.360 | 1.464 (0.648–3.307) | 0.001* | 4.782 (1.887–12.12) |
ER | Neg. vs. pos. | 0.934 | 0.960 (0.366–2.519) | 0.528 | 0.698 (0.230–2.123) |
PgR | Neg. vs. pos. | 0.142 | 0.770 (0.578–1.202) | 0.005* | 0.246 (0.092–0.656) |
Ki-67 | < 14% vs. 14% or more | 0.237 | 1.912 (0.653–5.602) | 0.310 | 2.171 (0.486–9.702) |
HER2 | Neg. vs. pos. | 0.600 | 1.377 (0.416–4.553) | 0.779 | 1.194 (0.335–4.132) |
Intrinsic subtype | Triple negative vs. others | 0.236 | 1.792 (0.683–4.695) | 0.115 | 2.445 (0.805–7.463) |
IMP | With IMP vs. without IMP | 0.064 | 2.032 (0.958–4.309) | 0.308 | 1.669 (0.624–4.462) |
BC-1514 (C15) | < 180 (median) vs. 180 or more | 0.476 | 1.342 (0.597–3.016) | 0.304 | 1.823 (0.580–5.726) |
BC-1514 (W12) | < 200 (median) vs. 200 or more | 0.613 | 1.290 (0.480–3.468) | 0.365 | 1.985 (0.451–8.739) |
CD1d | < 90 (median) vs. 90 or more | 0.674 | 0.843 (0.381–1.866) | 0.391 | 0.609 (0.196–1.890) |
PJA2 | < 180 (median) vs. 180 or more | 0.454 | 0.753 (0.357–1.584) | 0.742 | 0.847 (0.315–2.276) |