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Current Cardiovascular Imaging Reports

Erschienen in:

01.02.2011

Cellular and Functional Imaging of Cardiac Transplant Rejection

verfasst von: Yijen L. Wu, Qing Ye, Chien Ho

Erschienen in: Current Cardiovascular Imaging Reports | Ausgabe 1/2011

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Abstract

Heart transplantation is now an established treatment for patients suffering from end-stage heart diseases. With the advances in immunosuppressive treatment, the survival rate for transplant patients has improved greatly. However, allograft rejection, both acute and chronic, after heart transplantation is still a limitation leading to morbidity and mortality. The current clinical gold standard for screening rejection is endomyocardial biopsy (EMB), which is not only invasive, but also error-prone, due to the limited sample size and the site location of sampling. It would be highly desirable to have reliable and noninvasive alternatives for EMB in monitoring cardiac allograft rejection. The objective of this review is to highlight how cardiovascular imaging can contribute to noninvasively detecting and to evaluating both acute and chronic allograft rejection after heart transplantation, in particular, cardiovascular MRI (CMRI); and how CMRI can assess both immune cell infiltration at the rejecting organ, and the cardiac dysfunctions resulting from allograft rejection.

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Titel: Cellular and Functional Imaging of Cardiac Transplant Rejection
verfasst von: Yijen L. Wu
Qing Ye
Chien Ho
Publikationsdatum: 01.02.2011
Verlag: Current Science Inc.
Erschienen in: Current Cardiovascular Imaging Reports / Ausgabe 1/2011
Print ISSN: 1941-9066
Elektronische ISSN: 1941-9074
DOI: https://doi.org/10.1007/s12410-010-9055-3

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