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Current Gastroenterology Reports

Erschienen in:

01.11.2018 | Esophagus (J Clarke and N Ahuja, Section Editors)

Cellular Origins of Barrett’s Esophagus: the Search Continues

verfasst von: Horace Rhee, David H. Wang

Erschienen in: Current Gastroenterology Reports | Ausgabe 11/2018

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Abstract

Purpose of Review

The cellular origins of Barrett’s esophagus remain elusive. In this review, we discuss the potential cellular mechanisms behind squamous to columnar metaplasia as well as the limitations of these proposed mechanisms.

Recent Findings

Several theories have been proposed, including the reprogramming of native squamous cells, repopulation from submucosal glands, contributions from circulating bone marrow-derived cells, and direct extension of gastric cells. Most recent data support an innate progenitor cell unique to the squamocolumnar junction that can expand into metaplastic glands.

Summary

Active investigation to clarify each of these potential cells of origin is being pursued, but ultimately each could contribute to the pathogenesis of Barrett’s esophagus depending on the clinical context. Nonetheless, identifying cells of origin is critical to understand the molecular mechanisms behind Barrett’s esophagus and developing strategies to better treat (and possibly prevent) this increasingly significant premalignant disease.

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Titel: Cellular Origins of Barrett’s Esophagus: the Search Continues
verfasst von: Horace Rhee
David H. Wang
Publikationsdatum: 01.11.2018
Verlag: Springer US
Erschienen in: Current Gastroenterology Reports / Ausgabe 11/2018
Print ISSN: 1522-8037
Elektronische ISSN: 1534-312X
DOI: https://doi.org/10.1007/s11894-018-0657-2

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Recent Findings

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Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Adjuvante Immuntherapie verlängert Leben bei RCC

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