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Erschienen in: Clinical and Translational Oncology 3/2016

01.03.2016 | Review Article

Central nervous system niche involvement in the leukemia

verfasst von: N. Heidari, N. Saki, L. De Filippis, M. Shahjahani, A. Teimouri, A. Ahmadzadeh

Erschienen in: Clinical and Translational Oncology | Ausgabe 3/2016

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Abstract

Central nervous system (CNS) impairment is commonly involved in leukemia, as it can be observed upon onset or relapse of the disease. It is associated with poor prognosis and is a challenging clinical problem. The objective of this paper was to provide a characterization of the CNS niche in leukemia, to elucidate the culprits of CNS involvement, including diagnostic micro RNAs (miRs) and early leukemia prognosis. CNS niche is a proper location for homing of leukemic stem cells, thus representing a candidate target in the treatment of leukemia. Recent advances in the study of leukemia hallmarks have enlightened miRs as novel biomarkers for diagnosis and detection of CNS involvement in leukemia, thus providing the opportunity to develop novel therapeutic approaches. Given the importance of prognosis and early diagnosis of CNS involvement in leukemias as well as the severe side effects of current treatments, diagnostic and therapeutic approaches should focus on identification and inhibition of the factors contributing to CNS involvement, including CXCR3, P-selectin glycoprotein ligand-1 and MCP1. MiRs such as miR-221 and miR-222 are emerging as potential tools for an innovative non-invasive therapy of CNS in leukemia affected patients.
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Metadaten
Titel
Central nervous system niche involvement in the leukemia
verfasst von
N. Heidari
N. Saki
L. De Filippis
M. Shahjahani
A. Teimouri
A. Ahmadzadeh
Publikationsdatum
01.03.2016
Verlag
Springer Milan
Erschienen in
Clinical and Translational Oncology / Ausgabe 3/2016
Print ISSN: 1699-048X
Elektronische ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-015-1370-3

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