Central stress pathways in the development of cardiovascular disease
- 17.12.2023
- Review Article
Erschienen in:
- Verfasst von
- Joe Braun
- Mariya Patel
- Tatiana Kameneva
- Charlotte Keatch
- Gavin Lambert
- Elisabeth Lambert
- Erschienen in
- Clinical Autonomic Research | Ausgabe 1/2024
Abstract
Purpose
Mental stress is of essential consideration when assessing cardiovascular pathophysiology in all patient populations. Substantial evidence indicates associations among stress, cardiovascular disease and aberrant brain–body communication. However, our understanding of the flow of stress information in humans, is limited, despite the crucial insights this area may offer into future therapeutic targets for clinical intervention.
Methods
Key terms including mental stress, cardiovascular disease and central control, were searched in PubMed, ScienceDirect and Scopus databases. Articles indicative of heart rate and blood pressure regulation, or central control of cardiovascular disease through direct neural innervation of the cardiac, splanchnic and vascular regions were included. Focus on human neuroimaging research and the flow of stress information is described, before brain–body connectivity, via pre-motor brainstem intermediates is discussed. Lastly, we review current understandings of pathophysiological stress and cardiovascular disease aetiology.
Results
Structural and functional changes to corticolimbic circuitry encode stress information, integrated by the hypothalamus and amygdala. Pre-autonomic brain–body relays to brainstem and spinal cord nuclei establish dysautonomia and lead to alterations in baroreflex functioning, firing of the sympathetic fibres, cellular reuptake of norepinephrine and withdrawal of the parasympathetic reflex. The combined result is profoundly adrenergic and increases the likelihood of cardiac myopathy, arrhythmogenesis, coronary ischaemia, hypertension and the overall risk of future sudden stress-induced heart failure.
Conclusions
There is undeniable support that mental stress contributes to the development of cardiovascular disease. The emerging accumulation of large-scale multimodal neuroimaging data analytics to assess this relationship promises exciting novel therapeutic targets for future cardiovascular disease detection and prevention.
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- Titel
- Central stress pathways in the development of cardiovascular disease
- Verfasst von
-
Joe Braun
Mariya Patel
Tatiana Kameneva
Charlotte Keatch
Gavin Lambert
Elisabeth Lambert
- Publikationsdatum
- 17.12.2023
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
Clinical Autonomic Research / Ausgabe 1/2024
Print ISSN: 0959-9851
Elektronische ISSN: 1619-1560 - DOI
- https://doi.org/10.1007/s10286-023-01008-x
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