05.05.2023 | Scientific Letter
Cerebral Infarction from Sick Sinus Syndrome (Based on SCN5A) via Patent Foramen Ovale
verfasst von:
Shuang He, Lei Zhang, Xiao-Yan Liu, Xiao-Juan Ji, Shi-Long Tang, Xiao-Yun Wu, Tie-Wei Lu
Erschienen in:
Indian Journal of Pediatrics
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Ausgabe 8/2023
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Excerpt
To the Editor: A 9-y-old girl with hemiplegia as the initial symptom, suddenly developed left limb paralysis without obvious inducement and was admitted to our hospital. Cerebral infarction, characterized by significant reduction in the lumen of branches of the right middle cerebral artery, was confirmed through Cranial MRI and MRA. Meanwhile, the patient had recurrent bradycardia (sinus bradycardia/arrest) – tachycardia (atrial tachycardia/flutter) by detected by ECG and Holter monitoring and was positive for atropine test. Transesophageal ultrasound showed patent foramen ovale (PFO), and contrast echocardiography of the right heart indicated right-to-left shunt. Additionally, genetic examination suggested that the patient’s SCN5A gene had a heterozygous mutation (c.719dupT), leading to change in the corresponding amino acids (p. A242Gfs*11). …