Cerebral infarcts associated with adenomyosis: a rare risk factor for stroke in middle-aged women: a case series

Adenomyosis is a benign invasion of the endometrium into myometrium, which causes uterine enlargement, dysmenorrheal, menorrhagia, and menorrhalgia [1]. It typically occurs in the third to fifth decade of life. Adenomyosis is not routinely considered as a risk factor for ischemic stroke among young patients (under 50 years of age). Apart from the traditional vascular risk factors, migraine, illicit drug use, patent foramen ovale, oral contraceptives, and pregnancy or puerperium are the most prevalent “rare” risk factors for stroke in young adults [2]. We report here 3 cases with ischemic stroke and adenomyosis, and discuss the necessity to consider adenomyosis as a risk factor for stroke in middle-aged women.

We report in this study 3 cases who developed ischemic stroke during their menstruation. They did not have any cerebrovascular risk factors. Elevated CA125, CA19–9, and D-dimer levels were observed, which dropped significantly during the non-menstrual phase. All of them have adenomyosis. The levels of these markers returned to within normal ranges following hysterectomy in one of the patients.

In all the 3 patients, both the levels CA125 and CA19–9 were elevated, especially the CA125 level. However, no malignancies were found. CA125 is a member of the mucin family glycoproteins. Elevate serum CA125 level is most commonly seen in women with epithelial ovarian tumors, but also with endometriosis, pelvic inflammatory disease or adenomyosis [3]. Cerebral infarcts in adenomyosis patients have been previously reported before mostly in Japan. We summarized the characteristics of all the12 cases (including the current 3 cases) in Table 1. It is suggested that increased CA125 levels might play a role in the hypercoagulable state of the patients, which leads to the development of NBTE and increased aggregation of white and red blood cells [4]. Patients with adenomyosis are at risk of having an activated coagulation system, which leads to increased risk of thrombotic disorders [5]. Systemic embolism in the fingers or kidneys, as well as thrombi in the brachiocephalic trunk and left subclavian artery have been reported in adenomyosis cases [6]. NBTE, detected by TEE, has been found as the embolic source in 3 ischemic stroke patients with adenomyosis (Table 1). These reports indicate an underlying thromboembolic mechanism in adenomyosis patients with ischemic stroke. Although we did not confirm the existence of NBTE in our patients, a mechanism of thromboembolism can not be ruled out. Most NBTEs are discovered on autopsy but not antemortem, which may result from the difficulty in detecting these small sized vegetations under the cardiac valve [7]. It is also possible that the vegetations have already detached from the cardiac valve at the time of evaluation following the ischemic events.

Apart from thromboembolism, we believe stenosis of the cerebral artery may also be one of the mechanisms underlying adenomyosis associated ischemic stroke. Brain MRI revealed stenosis of the right PCA and ischemia in its territory in the third patient. Because of its hyperviscosity nature, CA125 has been suggested to be associated with the stenosis or occlusion of cerebral arteries by this mucinous protein itself [4]. However, further studies are needed to confirm this hypothesis.

All the 3 patients developed ischemic stroke in the menstrual phase. Consistently, another 2 cases were also confirmed to be in menstruation when they initially developed symptoms (Table 1). The serum CA125 levels vary at the different phases of the menstrual cycle, which peak during the menstruation [8]. The menstrual CA125 level can exceed the normal limit even in healthy women. The elevation of serum CA125 during menstruation is thought to be related with endometrial cell surface antigen shed into the systemic circulation or peritoneal irritation. In the current study, marked increased CA125 and D-dimer levels were detected during menstruation, indicating activated coagulation system associated with CA125. Besides, menstruation induced activation of the tissue factor coagulation pathway may also play a role in the abnormal coagulation of the adenomyosis patients [9]. Therefore, patients with adenomyosis are more likely to develop cerebral infarction during menstruation.

In conclusion, we report 3 adenomyosis patients who developed ischemic stroke during menstruation. These patients may be at risk of hypercoagulability associated with increased CA125 level and menstruation-related activation of coagulation pathway. The development of NBTE and stenosis of the cerebral arteries may be the underlying mechanisms leading to the cerebral infarction. Therefore, it is important to be aware of the adenomyosis as a risk factor for ischemic stroke in middle-aged patients. To our knowledge, this is the first report of Chinese cases with adenomyosis associated ischemic stroke.