The online version of this article (doi:10.1186/1752-1947-8-259) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
TT wrote the manuscript. TT and HU acquired patient data. HU and KM reviewed the case notes and were major contributors in writing the manuscript KN edited the manuscript and provided suggestions. All authors read and approved the final manuscript.
Cerebral salt-wasting syndrome is a condition featuring hyponatremia and dehydration caused by head injury, operation on the brain, subarachnoid hemorrhage, brain tumor and so on. However, there are a few reports of cerebral salt-wasting syndrome caused by cerebral infarction. We describe a patient with cerebral infarction who developed cerebral salt-wasting syndrome in the course of hemorrhagic transformation.
A 79-year-old Japanese woman with hypertension and arrhythmia was admitted to our hospital for mild consciousness disturbance, conjugate deviation to right, left unilateral spatial neglect and left hemiparesis. Magnetic resonance imaging revealed a broad ischemic change in right middle cerebral arterial territory. She was diagnosed as cardiogenic cerebral embolism because atrial fibrillation was detected on electrocardiogram on admission. She showed hyponatremia accompanied by polyuria complicated at the same time with the development of hemorrhagic transformation on day 14 after admission. Based on her hypovolemic hyponatremia, she was evaluated as not having syndrome of inappropriate secretion of antidiuretic hormone but cerebral salt-wasting syndrome. She fortunately recovered with proper fluid replacement and electrolyte management.
This is a rare case of cerebral infarction and cerebral salt-wasting syndrome in the course of hemorrhagic transformation. It may be difficult to distinguish cerebral salt-wasting syndrome from syndrome of inappropriate antidiuretic hormone, however, an accurate assessment is needed to reveal the diagnosis of cerebral salt-wasting syndrome because the recommended fluid management is opposite in the two conditions.
Peters JP, Welt LG, Sims EA, Orloff J, Needham J: A salt-wasting syndrome associated with cerebral disease. Trans Assoc Am Physicians. 1950, 63: 57-64. PubMed
Loo KL, Ramachandran R, Abdullah BJ, Chow SK, Goh EM, Yeap SS: Cerebral infarction and cerebral salt wasting syndrome in a patient with tuberculous meningoencephalitis. Southeast Asian J Trop Med Public Health. 2003, 34: 636-640. PubMed
- Cerebral salt-wasting syndrome due to hemorrhagic brain infarction: a case report
- BioMed Central