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01.03.2013 | Neuro | Ausgabe 3/2013

European Radiology 3/2013

Cerebral vein changes in relapsing-remitting multiple sclerosis demonstrated by three-dimensional enhanced T 2 * -weighted angiography at 3.0 T

Zeitschrift:
European Radiology > Ausgabe 3/2013
Autoren:
Chun Zeng, Xuan Chen, Yongmei Li, Yu Ouyang, Fajin Lv, Reshiana Rumzan, Zhongping Wang

Abstract

Objective

To investigate characteristics of the internal cerebral veins (ICVs) and their main tributaries and the deep medullary veins (DMVs) in patients with relapsing-remitting MS (RRMS) with enhanced T 2 * -weighted angiography imaging (ESWAN).

Methods

Fifty-three RRMS patients and 53 normal controls underwent conventional MRI and ESWAN. ESWAN venograms were created by performing minimum intensity projections of the phase images, and the resulting venograms were used to observe characteristic vascular changes, including scores of the ICVs and their main tributaries and manifestations of the DMVs. Two experienced radiologists analysed all data.

Results

Patients showed decreased mean scores of the ICVs and their main tributaries compared with controls. The mean score in acute patients was higher than in stable patients. Furthermore, the DMVs diminished and shortened in 48 patients with longer disease duration, whereas the DMVs increased and elongated in 5 patients with shorter disease duration. The penetrating veins were well defined in 30 active lesions, whereas the veins were ill defined in 69 non-active lesions. Interestingly, well-defined penetrating veins were shown in 15 non-active lesions in the stable patients.

Conclusions

Enhanced T 2 * -weighted MR angiography can detect cerebral vein characteristics in relapsing-remitting MS patients, which may provide important information on the pathogenesis of MS.

Key Points

Enhanced T 2 * -weighted magnetic resonance angiography (ESWAN) provides new insights into multiple sclerosis
ESWAN venograms clearly demonstrate the internal cerebral and deep medullary veins
The internal cerebral veins exhibit abnormalities in patients with relapsing-remitting MS
Deep medullary veins exhibit different manifestations in patients with different disease duration

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