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23.08.2018 | Neurology and Preclinical Neurological Studies - Short communication

Cerebrospinal fluid 5-HIAA concentrations correlate with cardiac uptake of ¹²³I-MIBG during myocardial scintigraphy in drug naïve Parkinson’s disease

verfasst von: Hidetomo Murakami, Ken Yamamoto, Taro Yasumoto, Atsushi Kimura, Yoshiki Sakae, Shohei Nomoto, Satomi Kubota, Daishi Watanabe, Keiko Watanabe, Yu Saito, Satoshi Yano, Kenjiro Ono

Erschienen in: Journal of Neural Transmission | Ausgabe 10/2018

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Abstract

We examined the correlations between cerebrospinal fluid (CSF) concentrations of homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA) and imaging assessment scores, using ¹²³I-Ioflupane SPECT and ¹²³I-MIBG myocardial scintigraphy in 23 drug naïve PD patients. The CSF 5-HIAA concentration correlated with the H/M ratio of the delayed image (r = 0.458, p < 0.05) and the washout rate (r = − 0.642, p < 0.01) of ¹²³I-MIBG myocardial scintigraphy. These correlations suggest some unclarified pathophysiological links between the central serotonergic and cardiac sympathetic systems.

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Titel: Cerebrospinal fluid 5-HIAA concentrations correlate with cardiac uptake of 123I-MIBG during myocardial scintigraphy in drug naïve Parkinson’s disease
verfasst von: Hidetomo Murakami
Ken Yamamoto
Taro Yasumoto
Atsushi Kimura
Yoshiki Sakae
Shohei Nomoto
Satomi Kubota
Daishi Watanabe
Keiko Watanabe
Yu Saito
Satoshi Yano
Kenjiro Ono
Publikationsdatum: 23.08.2018
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 10/2018
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-018-1917-x

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Cerebrospinal fluid 5-HIAA concentrations correlate with cardiac uptake of ¹²³I-MIBG during myocardial scintigraphy in drug naïve Parkinson’s disease

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