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22.11.2016 | Short Communication

Cerebrospinal fluid anti-Epstein-Barr virus specific oligoclonal IgM and IgG bands in patients with clinically isolated and Guillain-Barré syndrome

verfasst von: Diana Ferraro, Veronica Galli, Anna Maria Simone, Roberta Bedin, Francesca Vitetta, Elisa Merelli, Paolo Frigio Nichelli, Patrizia Sola

Erschienen in: Journal of NeuroVirology | Ausgabe 2/2017

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Abstract

Epstein-Barr virus (EBV) has been implicated in multiple sclerosis (MS) pathogenesis. We aimed to assess the frequency of EBV-specific IgG and IgM oligoclonal bands (OCB) in cerebrospinal fluid (CSF) of 50 patients with clinically isolated syndrome (CIS) and in 27 controls with Guillain-Barré syndrome (GBS). Furthermore, we assessed correlations between the presence of OCB and CIS patients’ CSF, MRI, and clinical variables. There was no difference in the proportion of CIS and GB patients with positivity for anti-EBV-specific IgG/IgM OCB. There were no correlations between OCB and analyzed variables, nor were they predictive of a higher disability at 3 years.

Ascherio A, Munger KL (2007) Environmental risk factors for multiple sclerosis. Part I: the role of infection. Ann Neurol 61:288–299CrossRefPubMed

Beltrán E, Obermeier B, Moser M, Coret F, Simó-Castelló M, Boscá I, Pérez-Miralles F, Villar LM, Senel M, Tumani H, Hohlfeld R, Casanova B, Dornmair K (2014) Intrathecal somatic hypermutation of IgM in multiple sclerosis and neuroinflammation. Brain 137:2703–2714CrossRefPubMed

Boscá I, Magraner MJ, Coret F, Alvarez-Cermeño JC, Simó-Castelló M, Villar LM, Casanova B (2010) The risk of relapse after a clinically isolated syndrome is related to the pattern of oligoclonal bands. J Neuroimmunol 226:143–146CrossRefPubMed

Castellazzi M, Contini C, Tamborino C, Fasolo F, Roversi G, Seraceni S, Rizzo R, Baldi E, Tola M, Bellini T, Granieri E, Fainardi E (2014) Epstein-Barr virus-specific intrathecal oligoclonal IgG production in relapsing-remitting multiple sclerosis is limited to a subset of patients and is composed of low-affinity antibodies. J Neuroinflammation 11:188CrossRefPubMedPubMedCentral

Cepok S, Zhou D, Srivastava R, Nessler S, Stei S, Büssow K, Sommer N, Hemmer B (2005) Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosis. Journ Clin Invest 115:1352–1360CrossRef

Farrell R, Antony D, Wall GR, Clark D, Fisniku L, Swanton J, Khaleeli Z, Schmierer K, Miller DH, Giovannoni G (2009) Humoral immune response to EBV in multiple sclerosis is associated with disease activity on MRI. Neurology 73:32–38CrossRefPubMedPubMedCentral

Ferraro D, Galli V, Vitetta F, Simone AM, Bedin R, Del Giovane C, Morselli F, Filippini MM, Nichelli PF, Sola P (2015) Cerebrospinal fluid CXCL13 in clinically isolated syndrome patients: association with oligoclonal IgM bands and prediction of multiple sclerosis diagnosis. J Neuroimmunol 283:64–69CrossRefPubMed

Ferraro D, Simone AM, Bedin R, Galli V, Vitetta F, Federzoni L, D’Amico R, Merelli E, Nichelli PF, Sola P (2013) Cerebrospinal fluid oligoclonal IgM bands predict early conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome. J Neuroimmunol 257:76–81CrossRefPubMed

Franciotta D, Di Stefano AL, Jarius S, Zardini E, Tavazzi E, Ballerini C, Marchioni E, Bergamaschi R, Ceroni M (2011) Cerebrospinal BAFF and Epstein-Barr virus-specific oligoclonal bands in multiple sclerosis and other inflammatory demyelinating neurological diseases. J Neuroimmunol 230:160–163CrossRefPubMed

Handel AE, Williamson AJ, Disanto G, Handunnetthi L, Giovannoni G, Ramagopalan SV (2010) An updated meta-analysis of risk of multiple sclerosis following infectious mononucleosis. PLoS One 5. doi:10.1371/journal,pone,0012496

Holmøy T, Kvale EØ, Vartdal F (2004) Cerebrospinal fluid CD4+ T cells from a multiple sclerosis patient cross-recognize Epstein-Barr virus and myelin basic protein. J Neurovirol 10:278–283CrossRefPubMed

Jafari N, van Nierop GP, Verjans GM, Osterhaus AD, Middeldorp JM, Hintzen RQ (2010) No evidence for intrathecal IgG synthesis to Epstein Barr virus nuclear antigen-1 in multiple sclerosis. J Clin Virol 49:26–31CrossRefPubMed

Jaquiéry E, Jilek S, Schluep M, Meylan P, Lysandropoulos A, Pantaleo G, Du Pasquier R (2010) Intrathecal immune responses to EBV in early MS. Eur J Immunol 40:878–887CrossRefPubMed

Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33:1444–1452CrossRefPubMed

Lang H, Jacobsen H, Ikemizu S, Andersson C, Harlos K, Madsen L, Hjorth P, Sondergaard L, Svejgaard A, Wucherpfennig K, Stuart DI, Bell JI, Jones EY, Fugger L (2002) A functional and structural basis for TCR cross-reactivity in multiple sclerosis. Nat Immunol 3:940–943CrossRefPubMed

Lünemann JD, Jelcić I, Roberts S, Lutterotti A, Tackenberg B, Martin R, Münz C (2008) EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-gamma and IL-2. J Exp Med 205:1763–1773CrossRefPubMedPubMedCentral

Lünemann JD, Tintoré M, Messmer B, Strowig T, Rovira A, Perkal H, Caballero E, Münz C, Montalban X, Comabella M (2010) Elevated Epstein-Barr virus-encoded nuclear antigen-1 immune responses predict conversion to multiple sclerosis. Ann Neurol 67:159–169CrossRefPubMedPubMedCentral

Pohl D, Rostasy K, Jacobi C, Lange P, Nau R, Krone B, Hanefeld F (2010) Intrathecal antibody production against Epstein-Barr and other neurotropic viruses in pediatric and adult onset multiple sclerosis. J Neurol 257:212–216CrossRefPubMed

Rand KH, Houck H, Denslow ND, Heilman KM (2000) Epstein-Barr virus nuclear antigen-1 (EBNA-1) associated oligoclonal bands in patients with multiple sclerosis. J Neurol Sci 173:32–39CrossRefPubMed

Villar L, García-Barragán N, Espiño M, Roldán E, Sádaba M, Gómez-Rial J, González-Porqué P, Alvarez-Cermeño J (2008) Influence of oligoclonal IgM specificity in multiple sclerosis disease course. Mult Scler 14:183–187CrossRefPubMed

Villar LM, González-Porqué P, Masjuán J, Alvarez-Cermeño JC, Bootello A, Keir G (2001) A sensitive and reproducible method for the detection of oligoclonal IgM bands. J Immunol Methods 258:151–155CrossRefPubMed

Virtanen JO, Wohler J, Fenton K, Reich DS, Jacobson S (2014) Oligoclonal bands in multiple sclerosis reactive against two herpesviruses and association with magnetic resonance imaging findings. Mult Scler 20:27–34CrossRefPubMed

Zivadinov R, Zorzon M, Weinstock-Guttman B, Serafin M, Bosco A, Bratina A, Maggiore C, Grop A, Tommasi MA, Srinivasaraghavan B, Ramanathan M (2009) Epstein-Barr virus is associated with grey matter atrophy in multiple sclerosis. J Neurol Neurosurg Psychiatry 80:620–625CrossRefPubMed

Titel: Cerebrospinal fluid anti-Epstein-Barr virus specific oligoclonal IgM and IgG bands in patients with clinically isolated and Guillain-Barré syndrome
verfasst von: Diana Ferraro
Veronica Galli
Anna Maria Simone
Roberta Bedin
Francesca Vitetta
Elisa Merelli
Paolo Frigio Nichelli
Patrizia Sola
Publikationsdatum: 22.11.2016
Verlag: Springer International Publishing
Erschienen in: Journal of NeuroVirology / Ausgabe 2/2017
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-016-0493-9

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Cerebrospinal fluid anti-Epstein-Barr virus specific oligoclonal IgM and IgG bands in patients with clinically isolated and Guillain-Barré syndrome

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