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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

05.05.2022 | Editorial

Cervical lymph node staging in head and neck tumors: bridging the gap between humans and companion animals

verfasst von: Lavinia Elena Chiti, M. C. Nolff, D. Stefanello

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 10/2022

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The role of companion animals in our society has shifted from merely utilitarian to social and emotional, leading to a constant increase in pet ownership in developed countries [ 1]. The estimated population of companion animals in 2018 reached 77 million dogs and 58 million cats in the USA, and 90 million dogs and 110 million cats in Europe [ 2]. As in humans, cancer is the leading cause of death, being diagnosed in up to 6 million dogs every year with fatal outcome in 45% of dogs older than 10 years and in 23% of dogs of all ages [ 3]. This scenario has promoted advancements in several branches of veterinary oncology and the development of sophisticated diagnostic techniques and therapeutic strategies that are comparable to the standards of care in humans. While the progress of veterinary oncology has traditionally followed the path of human medicine, recently, the potential of veterinary oncology to guide improvements in cancer treatment in humans has been disclosed, with growing attention being raised on the role of pet animals as models for diagnostics and drug development [ 3‐ 7]. Translational research on pet animals has tremendous advantages compared to rodent models. Dogs and cats develop tumors spontaneously and over time, as a result of complex biological interactions between cancer cells and the host’s immune system [ 5, 8]. Several tumor types share similar biological, genetic, and histological features with the human counterpart, providing an optimal model for evaluation of cancer natural biological mechanisms in immunocompetent and genetically variable subjects [ 5, 6, 9, 10]. Cancer development in pets resembles the natural step-wise evolution of human tumors, giving rise to spontaneous recurrences and metastases. Furthermore, pet animals have a comparatively shorter life-span and quicker cancer progression compared to men, allowing for time- and cost-effective evaluation of endpoints of interest, and share environmental risk factors with the owners, thus playing a potential role as sentinels [ 3, 8, 11, 12]. …

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Titel: Cervical lymph node staging in head and neck tumors: bridging the gap between humans and companion animals
verfasst von: Lavinia Elena Chiti
M. C. Nolff
D. Stefanello
Publikationsdatum: 05.05.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 10/2022
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-022-05829-2

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Cervical lymph node staging in head and neck tumors: bridging the gap between humans and companion animals

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