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06.11.2017 | Focus Session

Challenges for molecular and serological ZIKV infection confirmation

verfasst von: Zilton Farias Meira de Vasconcelos, Renata Campos Azevedo, Nathália Thompson, Leonardo Gomes, Letícia Guida, Maria Elisabeth Lopes Moreira

Erschienen in: Child's Nervous System | Ausgabe 1/2018

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Abstract

Background

Zika Virus (ZIKV), member of Flaviviridae family and Flavivirus genus, has recently emerged as international public health emergency after its association with neonatal microcephaly cases. Clinical diagnosis hindrance involves symptom similarities produced by other arbovirus infections, therefore laboratory confirmation is of paramount importance.

Discussion

The most reliable test available is based on ZIKV RNA detection from body fluid samples. However, short viremia window periods and asymptomatic infections diminish the success rate for RT-PCR positivity. Beyond molecular detection, all serology tests in areas where other Flavivirus circulates proved to be a difficult task due to the broad range of cross-reactivity, especially with dengue pre-exposed individuals.

Conclusion

Altogether, lack of serological diagnostic tools brings limitations to any retrospective evaluation. Those studies are central in the context of congenital infection that could occur asymptomatically and mask prevalence and risk rates.

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Titel: Challenges for molecular and serological ZIKV infection confirmation
verfasst von: Zilton Farias Meira de Vasconcelos
Renata Campos Azevedo
Nathália Thompson
Leonardo Gomes
Letícia Guida
Maria Elisabeth Lopes Moreira
Publikationsdatum: 06.11.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Child's Nervous System / Ausgabe 1/2018
Print ISSN: 0256-7040
Elektronische ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-017-3641-5

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Abstract

Background

Discussion

Conclusion

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