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Current Fungal Infection Reports

Erschienen in:

24.01.2018 | Clinical Pathology (C Sundaram, Section Editor)

Challenges in the Diagnosis of Invasive Fungal Infections in Immunocompromised Hosts

verfasst von: Spinello Antinori, Mario Corbellino, Carlo Parravicini

Erschienen in: Current Fungal Infection Reports | Ausgabe 1/2018

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Abstract

Purpose of review

The expanding population of immunocompromised patients coupled with the recognition of a growing number of different species of fungi responsible for diseases in such hosts makes the diagnosis of invasive fungal infection (IFI) a challenging task. The recent advances and challenges in the diagnosis of IFI in the setting of immunocompromised hosts are reviewed. The advantages and limitations of histopathology and the role of culture-independent methods, such as those based on the use of nucleic acids applied to fresh and formalin-fixed, paraffin-embedded sections, besides culture- and non-culture-based diagnostic methods, to obtain a timely and correct diagnosis of IFI are highlighted.

Recent findings

The therapeutic implications of identifying the genus and species of the fungus present in the specimen with the molecular diagnostics applied to tissue specimens are reviewed. No method alone is efficient in correctly identifying fungi and it is essential to combine the traditional histochemical staining with molecular methods to achieve a rapid and genus-/species-specific diagnosis of IFI.

Summary

We review the recent findings and challenges in the hystopathologic diagnosis of IFI in the setting of immunocompromised hosts. Non method alone is efficient in correctly identify fungi and pathologists should combine classic staining with molecular methods to achieve a rapid and genus/species fungal diagnosis.

Antinori S, Ridolfo AL, Fasan M, Magni C, Galimberti L, Milazzo L, et al. AIDS-associated cryptococcosis: a comparison of epidemiology, clinical features and outcome in the pre- and post-HAART eras. Experience of a single centre in Italy. HIV Med. 2009;10(1):6–11. https://doi.org/10.1111/j.1468-1293.2008.00645.x.CrossRefPubMed

Colombo AL, de Almeida Junior JN, Slavin MA, Chen SC, Sorrell TC. Candida and invasive mould diseases in non-neutropenic critically ill patients and patients with haematological cancer. Lancet Infect Dis. 2017;17(11):e344–56. https://doi.org/10.1016/S1473-3099(17)30304-3.CrossRefPubMed

Chamilos G, Lionakis MS, Kontoyiannis DP. Call for action: invasive fungal infections associated with ibrutinib and other small molecule kinase inhibitors targeting immune signalling pathways. Clin Infect Dis. 2017;66(1):140–8. https://doi.org/10.1093/cid/cix687.CrossRef

Gajurel K, Dhakal R, Deresinski S. Histoplasmosis in transplant recipients. Clin Transpl. 2017;31:10. https://doi.org/10.1111/ctr.13087.

Arvanitis M, Anagnostou T, Fuchs BB, Caliendo AM, Mylonakis E. Molecular and nonmolecular diagnostic methods for invasive fungal infections. Clin Microbiol Rev. 2014;27(3):490–526. https://doi.org/10.1128/CMR.00091-13.CrossRefPubMedPubMedCentral

Seidel D, Duran Graeff LA, Vehreschild MJ, Wisplinghoff H, Ziegler M, Vehreschild JJ, et al. FungiScope™: global emerging fungal infection registry. Mycoses. 2017;60(8):508–16. https://doi.org/10.1111/myc.12631.CrossRefPubMed

Guarner J. Incorporating pathology in the practice of infectious disease: myths and reality. Clin Infect Dis. 2014;59(8):1133–41. https://doi.org/10.1093/cid/ciu469.CrossRefPubMed

Procop GW, Wilson M. Infectious disease pathology. Clin Infect Dis. 2001;32(11):1589–601. https://doi.org/10.1086/320537.CrossRefPubMed

Martinez RM. Genes in your tissue: probe identification and sequencing microbial targets from formalin-fixed, paraffin-embedded tissue. Clin Microbiol Newslett. 2014;36(18):139–47. https://doi.org/10.1016/j.clinmicnews.2014.08.003.CrossRef

10.

Maertens JA, Blennow O, Duarte RF, Munoz P. The current management landscape: aspergillosis. J Antimicrob Chemother. 2016;71(Suppl 2):ii23–9. https://doi.org/10.1093/jac/dkw393.CrossRefPubMed

11.

Denning DW, Cadranel J, Beigelman-Aubry C, Ader F, Chakrabarti A, Blot S, et al. Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management. Eur Respir J. 2016;47(1):45–68. https://doi.org/10.1183/13993003.00583-2015.CrossRefPubMed

12.

•• Guarner J, Brandt ME. Histopathologic diagnosis of fungal infections in the 21^st century. Clin Microbiol Rev. 2011;24:247–80. https://doi.org/10.1128/CMR.00053-10. This paper remains the best comprehensive review of the histopathology of invasive fungal infections. CrossRefPubMedPubMedCentral

13.

Lee S, Yun NR, Kim K-H, Jeon JH, Kim EC, Chung DH, et al. Discrepancy between histology and culture in filamentous fungal infections. Med Mycol. 2010;48(6):886–8. https://doi.org/10.3109/13693780903512835.CrossRefPubMed

14.

Shah AA, Hazen KC. Diagnostic accuracy of histopathologic and cytopathologic examination of Aspergillus species. Am J Clin Pathol. 2013;139(1):55–61. https://doi.org/10.1309/AJCPO8VTSK3HRNUT.CrossRefPubMed

15.

Sangoi AR, Rogers WM, Longacre TA, Montoya JG, Baron EJ, Banaei N. Challenges and pitfalls of morphologic identification of fungal infections in histologic and cytologic specimens. A ten-year retrospective review at a single institution. Am J Clin Pathol. 2009;131(3):364–75. https://doi.org/10.1309/AJCP99OOOZSNISCZ.CrossRefPubMed

16.

Dekio F, Bhatti TR, Zhang SX, Sullivan KV. Positive impact of fungal histopathology on immunocompromised pediatric patients with histology-proven invasive fungal infection. Am J Clin Pathol. 2015;144(1):61–7. https://doi.org/10.1309/AJCPEMVYT88AVFKG.CrossRefPubMed

17.

Lau A, Chen S, Sorrell T, Carter D, Malik R, Martin P, et al. Development and clinical application of a panfungal PCR assay to detect and identify fungal DNA in tissue specimens. J Clin Microbiol. 2007;45(2):380–5. https://doi.org/10.1128/JCM.01862-06.CrossRefPubMed

18.

Moncada PA, Budvytiene I, Ho DH, Deresinski SC, Montoya JG, Banaei N. Utility of DNA sequencing for direct identification of invasive fungi from fresh and formalin-fixed specimens. Am J Clin Pathol. 2013;140(2):203–8. https://doi.org/10.1309/AJCPNSU2SDZD9WPW.CrossRefPubMed

19.

Munoz-Cadavid C, Rudd S, Zaki SR, Patel M, Moser SA, Brandt ME, et al. Improving molecular detection of fungal DNA in formalin-fixed paraffin-embedded tissues: comparison of five tissue DNA extraction methods using panfungal PCR. J Clin Microbiol. 2010;48(6):2147–53. https://doi.org/10.1128/JCM.00459-10.CrossRefPubMedPubMedCentral

20.

Halliday CL, Kidd SE, Sorrell TC, Chen SC. Molecular diagnostic methods for invasive fungal disease: the horizon draws nearer? Pathology. 2015;47(3):257–69. https://doi.org/10.1097/PAT.0000000000000234.CrossRefPubMed

21.

• Salehi E, Hedayati MT, Zoll J, Rafati H, Ghasemi M, Doroudinia A, et al. Discrimination of aspergillosis, mucormycosis, fusariosis, and scedosporiosis in formalin-fixed paraffin-embedded tissue specimens by use of multiple real-time quantitative PCR assays. J Clin Microbiol. 2016;14:2798–803. https://doi.org/10.1128/JCM.01185-16. A multicenter study regarding the use of multiple real-time quantitative PCR assays of formalin-fixed paraffin-embedded tissue specimens to identify Aspergillus , Fusarium , Scedosporium , and Mucormycetes. CrossRef

22.

Chowdhary A, Sharma C, Meis JF. Azole-resistant aspergillosis: epidemiology, molecular mechanisms, and treatment. J Infect Dis. 2017;216(S3):S436–44. https://doi.org/10.1093/infdis/jix210.CrossRefPubMed

23.

van der Linden JW, Snelders E, Kampinga GA, Rijnders BJ, Mattson E, Debets-Ossenkopp YJ, et al. Clinical implications of azole resistance to Aspergillus fumigatus, the Netherlands, 2007–2009. Emerg Infect Dis. 2011;17(10):1846–54. https://doi.org/10.3201/eid1710.110226.CrossRefPubMedPubMedCentral

24.

Howard SJ, Cerar D, Anderson MJ, Albarraq A, Fischer MC, Pasqualotto AC, et al. Frequency and evolution of azole resistance in Aspergillus fumigatus associated treatment failure. Emerg Infect Dis. 2009;15(7):1068–76. https://doi.org/10.3201/eid1507.090043.CrossRefPubMedPubMedCentral

25.

van der Linden JW, Snelders E, Arends JP, Daenen SM, Melchers WJ, Verweij PE. Rapid diagnosis of azole-resistant aspergillosis by direct PCR using tissue specimens. J Clin Microbiol. 2010;48(4):1478–80. https://doi.org/10.1128/JCM.02221-09.CrossRefPubMedPubMedCentral

26.

McKinnell JA, Pappas GA. Blastomycosis: new insights into diagnosis, prevention and treatment. Clin Chest Med. 2009;30(2):227–39. https://doi.org/10.1016/j.ccm.2009.02.003.CrossRefPubMed

27.

Pappas PG, Threlkeld MG, Bedsole GD, Cleveland KO, Gelfand MS, Dismukes WE. Blastomycosis in immunocompromised patients. Medicine. 1993;72(5):311–25. https://doi.org/10.1097/00005792-199309000-00003.CrossRefPubMed

28.

Taxy J. Blastomycosis: contributions of morphology to diagnosis. A surgical pathology, cytopathology and autopsy pathology study. Am J Surg Pathol. 2007;31(4):615–23. https://doi.org/10.1097/01.pas.0000213389.47913.b8.CrossRefPubMed

29.

Patel AJ, Gattuso P, Reddy VB. Diagnosis of blastomycosis in surgical pathology and cytopathology: correlation with microbiologic culture. Am J Surg Pathol. 2010;34(2):256–61. https://doi.org/10.1097/PAS.0b013e3181ca48a5.CrossRefPubMed

30.

Takahashi Y, Nagata N, Shimbo T, Nishijima T, Watanabe K, Aoki T, et al. Upper gastrointestinal symptoms predictive of Candida esophagitis and erosive esophagitis in HIV and non-HIV patients: an endoscopy based cross-sectional study of 6011 patients. Medicine. 2015;94(47):e2138. https://doi.org/10.1097/MD.0000000000002138.CrossRefPubMedPubMedCentral

31.

Alsomali MI, Arnold MA, Frankel WL, Graham RP, Hart PA, Lam-Himlin DM, et al. Challenges to “classic” esophageal candidiasis. Looks are usually deceiving. Am J Clin Pathol. 2017;147(1):33–42. https://doi.org/10.1093/ajcp/aqw210.PubMed

32.

Clancy CJ, Nguyen MH. Finding the “missing 50%” of invasive candidiasis: how nonculture diagnostics will improve understanding of disease spectrum and transform patient care. Clin Infect Dis. 2013;56(9):1284–92. https://doi.org/10.1093/cid/cit006.CrossRefPubMed

33.

Antinori S, Milazzo L, Sollima S, Galli M, Corbellino M. Candidemia and invasive candidiasis in adults: a narrative review. Eur J Intern Med. 2016;34:21–8. https://doi.org/10.1016/j.ejim.2016.06.029.CrossRefPubMed

34.

Bassetti M, Garnacho-Montero J, Calandra T, Kullberg B, Dimopoulos G, Azoulay E, et al. Intensive care medicine research agenda on invasive fungal infection in critically ill patients. Intensive Care Med. 2017;43(9):1225–38. https://doi.org/10.1007/s00134-017-4731-2.CrossRefPubMed

35.

Nguyen C, Barker BM, Hoover S, Nix DE, Ampel NM, Frelinger JA, et al. Recent advances in our understanding of the environmental, epidemiological, immunological, and clinical dimensions of coccidioidomycosis. Clin Microbiol Rev. 2013;26(3):505–25. https://doi.org/10.1128/CMR.00005-13.CrossRefPubMedPubMedCentral

36.

Galgiani JN, Ampel NM, Blair JE, Catanzaro A, Johnson RH, Stevens DA, et al. Coccidioidomycosis. Clin Infect Dis. 2005;41(9):1217–23. https://doi.org/10.1086/496991.CrossRefPubMed

37.

Saubolle MA. Laboratory aspects in the diagnosis of coccidioidomycosis. Ann N Y Acad Sci. 2007;1111:310–4. https://doi.org/10.1196/annals.1406.049.CrossRef

38.

Aly FZ, Millius R, Sobonya R, Aboul-Nasr K, Klein R. Cytologic diagnosis of coccidioidomycosis. Spectrum of findings in Southern Arizona patients over a 10 year period. Diagn Cytopathol. 2016;44(3):195–200. https://doi.org/10.1002/dc.23419.CrossRefPubMed

39.

Shekhel TA, Ricciotti RW, Blair JE, Colby TV, Sobonya RE, Larsen BT. Surgical pathology of pleural coccidioidomycosis: a clinicopathological study of 38 cases. Hum Pathol. 2014;45(5):961–9. https://doi.org/10.1016/j.humpath.2013.12.009.CrossRefPubMed

40.

Ricciotti RW, Shekhel TA, Blair JE, Colby TV, Sobonya RE, Larsen BT. Surgical pathology of skeletal coccidioidomycosis. A clinical and histopathologic analysis of 25 cases. Am J Surg Pathol. 2014;38(12):1672–80. https://doi.org/10.1097/PAS.0000000000000284.CrossRefPubMed

41.

Binnicker MJ, Buckwalter SP, Eisberner JJ, Stewart RA, McCullogh AE, Wohlfiel SL, et al. Detection of Coccidioides species in clinical specimens by real-time PCR. J Clin Microbiol. 2007;45(1):173–8. https://doi.org/10.1128/JCM.01776-06.CrossRefPubMed

42.

Montone KT, Litzky LA, Feldman MD, Peterman H, Mathis B, Baliff J, et al. In situ hybridization for Coccidioides immitis 5.8S ribosomal RNA sequences in formalin-fixed, paraffin-embedded pulmonary specimens using a locked nucleic acid probe. A rapid means for identification in tissue section. Diagn Mol Pathol. 2010;19(2):99–104. https://doi.org/10.1097/PDM.0b013e3181b3aa55.CrossRefPubMed

43.

Park BJ, Wannemuehler KA, Maraton BJ, Govender N, Pappas PG, Chiller TM. Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS. 2009;23:525–30. https://doi.org/10.1097/QAD.0b013e328322ffac.CrossRefPubMed

44.

Rajasingham R, Smith RM, Park BJ, Jarvis JN, Govender NP, Chiller TM, et al. Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis. Lancet Infect Dis. 2017;17(8):873–81. https://doi.org/10.1016/S1473-3099(17)30243-8.CrossRefPubMedPubMedCentral

45.

May RC, Stone NR, Wiesner DL, Bicanic T, Nielsen K. Cryptococcus: from environmental saprophyte to global pathogen. Nat Rev Microbiol. 2016;14(2):106–17. https://doi.org/10.1038/nrmicro.2015.6.CrossRefPubMed

46.

• Hagen F, Khayhan K, Theelen B, Kolecka A, Polacheck I, Sionov E, et al. Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex. Fungal Genet Biol. 2015;78:16–48. https://doi.org/10.1016/j.fgb2015.02.009. The original study reporting the new proposed classification of Cryptococcus species. CrossRefPubMed

47.

Kwon-Chung KJ, Bennett JE, Wickes BL, Meyer W, Cuomo CA, Wollenburg KR, et al. The case for adopting the “species complex” nomenclature fort the etiologic agents of cryptococcosis. mSphere. 2017;2:e00357–16. https://doi.org/10.1128/mSphere.00357-16.CrossRefPubMedPubMedCentral

48.

Hagen F, Lumbsch HT, Arsic Arsenijevic V, Badali H, Bertout S, Billmyre RB, et al. Importance of resolving fungal nomenclature: the case of multiple pathogenic species in the Cryptococcus genus. mSphere. 2017;2:e00238–17. https://doi.org/10.1128/mSphere.00238-17.CrossRefPubMedPubMedCentral

49.

Antinori S, Radice A, Galimberti L, Magni C, Fasan M, Parravicini C. The role of cryptococcal antigen assay in diagnosis and monitoring of cryptococcal meningitis. J Clin Microbiol. 2005;43(11):5828–9. https://doi.org/10.1128/JCM.43.11.5828-5829.2005.CrossRefPubMedPubMedCentral

50.

Huang H, Fan L, Rajbanshi B, Xu JF. Evaluation of a new cryptococcal antigen lateral flow immunoassay in serum, cerebrospinal fluid and urine for the diagnosis of cryptococcosis: a meta-analysis and systematic review. PLoS One. 2015;10(5):e0127117. https://doi.org/10.1371/journal.pone.0127117.CrossRefPubMedPubMedCentral

51.

Chastain DB, Guarner J, Franco-Paredes C. Cryptococcal antigen negative meningoencephalitis in HIV/AIDS. Diagn Microbiol Infect Dis. 2017;89(2):143–5. https://doi.org/10.1016/j.diagmicrobio.2017.06.016.CrossRefPubMed

52.

Ranjan R, Jain D, Singh L, Iyer VK, Sharma MC, Mathur SR. Differentiation of histoplasma and cryptococcus in cytology smears: a diagnostic dilemma in severely necrotic cases. Cytopathology. 2015;26(4):244–9. https://doi.org/10.1111/cyt.12180.CrossRefPubMed

53.

Rajeshwari M, Xess I, Sharma MC, Jain D. Acid-fastness of Histoplasma in surgical pathology practice. J Pathol Transl Med. 2017;51(5):482–7. https://doi.org/10.4132/jptm.2017.07.11.CrossRefPubMedPubMedCentral

54.

Antinori S, Galimberti L, Magni C, Casella A, Vago L, Mainini F, et al. Cryptococcus neoformans infection in a cohort of Italian AIDS patients: natural history, early prognostic parameters, and autopsy findings. Eur J Clin Microbiol Infect Dis. 2001;20(10):711–7. https://doi.org/10.1007/s100960100616.CrossRefPubMed

55.

Torres RG, Etchebehere RM, Adad SJ, Micheletti AR, Ribeiro BM, Silva LE, et al. Cryptococcosis in acquired immunodeficiency syndrome patients clinically confirmed and/or diagnosed at necropsy in a teaching hospital in Brazil. Am J Trop Med Hyg. 2016;95(4):781–5. https://doi.org/10.4269/ajtmh.16-0148.CrossRefPubMed

56.

Antinori S, Nebuloni M, Magni C, Fasan M, Adorni F, Viola A, et al. Trends in the postmortem diagnosis of opportunistic invasive fungal infections in patients with AIDS: a retrospective study of 1,630 autopsies performed between 1984 and 2002. Am J Clin Pathol. 2009;132(2):221–7. https://doi.org/10.1309/AJCPRAAE8LZ7DTNE.CrossRefPubMed

57.

Gori S, Drouhet E, Gueho E, Huerre M, Lofaro A, et al. Cutaneous disseminated mycosis in a patient with AIDS due to a new dimorphic fungus. J Mycol Med. 1998;8:57–63.

58.

Schwartz IS, Kenyon C, Feng P, Govender NP, Dukik K, Sigler L, et al. 50 years of Emmonsia disease in humans: the dramatic emergence of a cluster of novel fungal pathogens. PLoS Pathog. 2015;11(11):e1005198. https://doi.org/10.1371/journal.ppat.1005198.CrossRefPubMedPubMedCentral

59.

Kenyon C, Bonorchis K, Corcoran C, Meintjes G, Locketz M, Lehloenya R, et al. A dimorphic fungus causing disseminated infection in South Africa. N Engl J Med. 2013;369(15):1416–24. https://doi.org/10.1056/NEJMoa1215460.CrossRefPubMed

60.

Dukik K, Munoz JF, Jiang Y, Feng P, Sigler L, Stielow JB, et al. Novel taxa of thermally dimorphic systemic pathogens in the Ajellomycetaceae (Onygenales). Mycoses. 2017;60(5):296–309. https://doi.org/10.1111/myc.12601.CrossRefPubMedPubMedCentral

61.

Wang O, Kenyon C, De HG, Guo L, Fan H, Liu H, et al. A novel dimorphic pathogen, Emergomyces orientalis (Onygenales) , agent of disseminated infection. Mycoses. 2017;60(5):310–9. https://doi.org/10.1111/myc.12583.CrossRefPubMed

62.

Schwartz IS, Govender NP, Corcoran C, Dlamini S, Prozesky H, Burton R, et al. Clinical characteristics, diagnosis, management, and outcomes of disseminated emmonsiosis: a retrospective case series. Clin Infect Dis. 2015;61(6):1004–12. https://doi.org/10.1093/cid/civ439.CrossRefPubMed

63.

Bahr N, Antinori S, Wheat L, Sarosi G. Histoplasmosis infections worldwide: thinking outside of the Ohio River valley. Curr Trop Med Rep. 2015;2(2):70–80. https://doi.org/10.1007/s40475-015-0044-0.CrossRefPubMedPubMedCentral

64.

Antinori S. Histoplasma capsulatum: more widespread than previously thought. Am J Trop Med Hyg. 2014;90(6):982–3. https://doi.org/10.4269/ajtmh.14-0175.CrossRefPubMedPubMedCentral

65.

Wheat LJ, Azar MM, Bahr N, Spec A, Relich RF, Hage C. Histoplasmosis. Infect Dis Clin N Am. 2016;30(1):207–27. https://doi.org/10.1016/j.idc.2015.10.009.CrossRef

66.

Hage CA, Azar MM, Bahr N, Loyd J, Wheat LJ. Histoplasmosis: up-to-date evidence-based approach to diagnosis and management. Semin Respir Crit Care Med. 2015;36:738–54. https://doi.org/10.1055/s.0035-1562899.

67.

Vergidis P, Avery RK, Wheat LJ, Dotson JL, Assi MA, Antoun SA, et al. Histoplasmosis complicating tumor necrosis factor-alpha blocker therapy: a retrospective analysis of 98 cases. Clin Infect Dis. 2015;61(3):409–17. https://doi.org/10.1093/cid/civ299.CrossRefPubMedPubMedCentral

68.

Guarner J. Human immunodeficiency virus and fungal infections. Sem Diagn Pathol. 2017;34:325–31. https://doi.org/10.1053/j.semdp.2017.04.007.CrossRef

69.

Gupta N, Arora S, Rajwanshi A, Nijhawan R, Srinivasan R. Histoplasmosis: cytodiagnosis and review of literature with special emphasis on differential diagnosis on cytomorphology. Cytopathology. 2010;21(4):240–4. https://doi.org/10.1111/j.1365-2303.2009.00693.x.CrossRefPubMed

70.

Sharma S, Gupta P, Gupta N, Lai A, Behera D, Rajwanshi A. Pulmonary infections in immunocompromised patients: the role of image-guided fine needle aspiration cytology. Cytopathology. 2017;28(1):46–54. https://doi.org/10.1111/cyt.12359.CrossRefPubMed

71.

• Azar MM, Hage CH. Laboratory diagnostics for histoplasmosis. J Clin Microbiol. 2017;55:1612–20. https://doi.org/10.1128/JCM.02430-16. A short excellent review discussing all aspects of histoplasmosis diagnosis including tissue diagnosis. CrossRefPubMedPubMedCentral

72.

Gailey MP, Keeney ME, Jensen CS. A cytomorphometric analysis of pulmonary and mediastinal granulomas: differentiating histoplasmosis from sarcoidosis by fine-needle aspiration. Cancer Cytopathol. 2015;123(1):51–8. https://doi.org/10.1002/cncy.21491.CrossRefPubMed

73.

Field AS, Geddie WR. Role of fine needle aspiration biopsy cytology in the diagnosis of infection. Diagn Cytopathol. 2016;44(12):1024–38. https://doi.org/10.1002/dc.23568.CrossRefPubMed

74.

Mukhopadhyay S, Gal AA. Granulomatous lung disease. An approach to the differential diagnosis. Arch Pathol Lab Med. 2010;134(5):667–90. https://doi.org/10.1043/1543-2165-134.5.667.PubMed

75.

Mukhopadhyay S, Farver CF, Vaszar LT, Dempsey OJ, Popper HH, Mani H, et al. Causes of pulmonary granulomas: a retrospective study of 500 cases from seven countries. J Clin Pathol. 2012;65(1):51–7. https://doi.org/10.1136/jclinpath-2011-200336.CrossRefPubMed

76.

Koepsell SA, Hinrichs SH, Iwen PC. Applying a real-time PCR assay for Histoplasma capsulatum to clinically relevant formalin-fixed paraffin-embedded human tissue. J Clin Microbiol. 2012;50(10):3395–7. https://doi.org/10.1128/JCM.01705-12.CrossRefPubMedPubMedCentral

77.

Frickmann H, Loderstaedt U, Racz P, Tenner-Racz K, Eggert P, Haeupler A, et al. Detection of tropical fungi in formalin-fixed, paraffin-embedded tissue: still an indication for microscopy in times of sequence-based diagnosis? BioMed Res Intern. 2015;2015:938721. https://doi.org/10.1155/2015/938721.

78.

Kwon-Chung KJ. Taxonomy of fungi causing Mucormycosis and Entomophthoramycosis (Zygomycosis) and nomenclature of the disease: molecular mycologic perspectives. Clin Infect Dis. 2012;54(S1):S8–15. https://doi.org/10.1093/cid/cir864.CrossRefPubMedPubMedCentral

79.

Meis JF, Chakrabarti A. Changing epidemiology of an emerging infection: zygomycosis. Clin Microbiol Infect. 2009;15(Suppl.5):10–4. https://doi.org/10.1111/j.1469-0691.2009.02973.x.CrossRefPubMed

80.

Gomez MZ, Lewis RE, Kontoyannis DP. Mucormycosis caused by unusual mucormycetes, non-Rhizopus, -Mucor, and -Lichtemia species. Clin Microbiol Rev. 2011;24(2):411–45. https://doi.org/10.1128/CMR.00056-10.CrossRef

81.

Ben-Ami R, Luna M, Lewis RE, Walsh TJ, Kontoyannis DP. A clinicopathological study of pulmonary mucormycosis in cancer patients: extensive angioinvasion but limited inflammatory response. J Infect. 2009;59:134–8. https://doi.org/10.1016/j.jinf.2009.06.002.CrossRefPubMed

82.

Jung J, Park YS, Sung H, Song JS, Lee SO, Choi SH, et al. Using immunohistochemistry to assess the accuracy of histomorphologic diagnosis of aspergillosis and mucormycosis. Clin Infect Dis. 2015;61(11):1664–70. https://doi.org/10.1093/cid/civ660.PubMed

83.

Drogari-Apiranthitou M, Panayiotides I, Galani I, Konstantoudakis S, Arvanitidis G, Spathis A, et al. Diagnostic value of a semi-nested PCR for the diagnosis of mucormycosis and aspergillosis from paraffin-embedded tissue: a single-center experience. Pathol Res Prac. 2016;212(5):393–7. https://doi.org/10.1016/j.prp.2016.02.010.CrossRef

84.

Ng V, Yajko D, Hadley W. Extrapulmonary pneumocystosis. Clin Microbiol Rev. 1997;10(3):401–18.PubMedPubMedCentral

85.

Fillatre P, Decaux O, Jouneau S, Revest M, Gacouin A, Robert-Gangneux F, et al. Incidence of Pneumocystis jiroveci pneumonia among groups at risk in HIV-negative patients. Am J Med. 2014;127:1241.e11–7. https://doi.org/10.1016/j.amjmed.2014.07.010.

86.

Thomas CF Jr, Limper AH. Pneumocystis pneumonia. N Engl J Med. 2004;350:2487–98. https://doi.org/10.1056/NEJMra032588.CrossRefPubMed

87.

Doyle L, Vogel S, Procop GW. Pneumocystis PCR: it is time to make PCR the test of choice. Open Forum Infect Dis. 2017;4(4):ofx193. https://doi.org/10.1093/ofid/ofx193.eCollection. 2017 FallCrossRefPubMedPubMedCentral

88.

Damiani C, Le Gal S, Da Costa C, Virmaux M, Nevez G, Totet A. Combined quantification of pulmonary Pneumocystis jirovecii DNA and serum (1→3)-β-D-glucan for differential diagnosis of Pneumocystis pneumonia and Pneumocystis colonization. J Clin Microbiol. 2013;51(10):3380–8. https://doi.org/10.1128/JCM.01554-13.CrossRefPubMedPubMedCentral

89.

Hartel PH, Shilo K, Klassen-Fischer M, Neafie RC, Ozbudak IH, Galvin JR, et al. Granulomatous reaction to Pneumocystis jirovecii. Clinicopathologic review of 20 cases. Am J Surg Pathol. 2010;34(5):730–4. https://doi.org/10.1097/PAS.0b013e3181d9f16a.PubMed

90.

Limper AH, Adenis A, Le T, Harrison TS. Fungal infections in HIV/AIDS. Lancet Infect Dis. 2017;17(11):e334–43. https://doi.org/10.1016/S1473-3099(17)30303-1.CrossRefPubMed

91.

Chan JF, Chan TS, Gill H, Lam FY, Trendell-Smith NJ, Sridhar S, et al. Disseminated infections with Talaromyces marneffei in non-AIDS patients given monoclonal antibodies against CD20 and kinase inhibitors. Emerg Infect Dis. 2015;21(7):1101–6. https://doi.org/10.3201/eid2107.150138.CrossRefPubMedPubMedCentral

92.

Antinori S, Gianelli E, Bonaccorso C, Ridolfo AL, Croce F, Sollima S, et al. Disseminated Penicillium marneffei infection in an HIV-positive Italian patient and a review of cases reported outside endemic regions. J Travel Med. 2006;13(3):181–8. https://doi.org/10.1111/j.1708-8305.2006.00039.x.CrossRefPubMed

93.

Wong KF. Marrow penicilliosis: a readily missed diagnosis. Am J Clin Pathol. 2010;134(2):214–8. https://doi.org/10.1309/AJCPWVBQCW13DJLO.CrossRefPubMed

94.

Qiu Y, Liao H, Zhang J, Zhong X, Tan C, Lu D. Differences in clinical characteristics and prognosis of Penicilliosis among HIV-negative patients with or without underlying disease in Southern China: a retrospective study. BMC Infect Dis. 2015;15(1):525. https://doi.org/10.1186/s12879-015-1243-y.CrossRefPubMedPubMedCentral

95.

Lim D, Lee YS, Chang AR. Rapid diagnosis of Penicillium marneffei infection by fine needle aspiration cytology. J Clin Pathol. 2006;59(4):443–4. https://doi.org/10.1136/jcp.2004.024976.CrossRefPubMedPubMedCentral

96.

Alsharif M, Cameron SE, Young JA, Savik K, Henriksen JC, Gulbahce HE, et al. Time trends in fungal infections as a cause of death in hematopoietic stem cell transplant recipients. Am J Clin Pathol. 2009;132(5):746–55. https://doi.org/10.1309/AJCPV9DC4HGPANKR.CrossRefPubMed

97.

Colombo TE, Nunes Soares MM, D’Avilla SC, Nogueira MC, de Almeida MT. Identification of fungal diseases at necropsy. Pathol Res Pract. 2012;208(9):549–52. https://doi.org/10.1016/j.prp.2012.06.004.CrossRefPubMed

98.

• Dignani MC. Epidemiology of invasive fungal diseases on the basis of autopsy reports. F1000Prime Rep. 2014;6:81. https://doi.org/10.12703/P6-81. A short review on IFIs detected at autopsy in different population of immunocompromised patients. CrossRefPubMedPubMedCentral

99.

Rickerts V. Identification of fungal pathogens in formalin-fixed, paraffin-embedded tissue samples by molecular methods. Fungal Biol. 2016;120(2):279–87. https://doi.org/10.1016/j.funbio.2015.07.002.CrossRefPubMed

100.

Ruangritchankul K, Chindamporn A, Worasilchai N, Poumsuk U, Keelawat S, Bychlov A. Invasive fungal disease in university hospital: a PCR-based study of autopsy cases. Int J Exp Pathol. 2015;8:14840–52.

Titel: Challenges in the Diagnosis of Invasive Fungal Infections in Immunocompromised Hosts
verfasst von: Spinello Antinori
Mario Corbellino
Carlo Parravicini
Publikationsdatum: 24.01.2018
Verlag: Springer US
Erschienen in: Current Fungal Infection Reports / Ausgabe 1/2018
Print ISSN: 1936-3761
Elektronische ISSN: 1936-377X
DOI: https://doi.org/10.1007/s12281-018-0306-0

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Challenges in the Diagnosis of Invasive Fungal Infections in Immunocompromised Hosts

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