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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Oral Health 1/2015

Change of periodontal inflammatory indicators through a 4-week weight control intervention including caloric restriction and exercise training in young Koreans: a pilot study

Zeitschrift:
BMC Oral Health > Ausgabe 1/2015
Autoren:
Hoo-Seob Park, Hae-Sung Nam, Hyung-Seok Seo, Soo-Jeong Hwang
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

HSP and HSN conceived of the study, and participated in its design and helped to draft the manuscript. HSS carried out the weight control program. SJH carried out the assay of periodontal biomarker and oral examination, and performed statistical analysis. All authors participated in the writing process, read and approved the final manuscript.

Authors’ information

HSP: PhD candidate, Chungnam National University, SouthKorea. HSN: Professor, Chungnam National University, SouthKorea. HSS: Professor, Konyang University, South Korea. SJH: Professor, Konyang University, South Korea

Availability of data and materials

Not applicable.

Abstract

Background

Recent cross-sectional studies indicate that obesity is a risk factor for periodontal disease. Exercise training in high fat mice or rats can inhibit gingival inflammation effectively. The objective of this human intervention study was to investigate whether short-term weight control could affect periodontal indexes and serum and gingival crevicular fluid (GCF) biomarkers in young Koreans.

Methods

Forty-one obese volunteers (body mass index (BMI) > 25.0) and 12 normal weight subjects (18.5 ≤ BMI ≤ 23.0) participated in a four-week weight control program to analyze the changes in anthropometric criteria, the concentrations of C-reactive protein (CRP), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides in serum, gingival index, bleeding on probing, periodontal biomarkers in GCF, and dental plaque index at the first and the 27th days.

Results

The means of obesity measures decreased significantly more in the obese group (BMI 2.53 ± 0.96, waist-to-hip ratio (WHR) 4.88 ± 1.58 %, LDL 35.85 ± 21.74 mgdL−1) than in the normal weight group (BMI 0.78 ± 0.72, WHR 2.00 ± 0.95 %, LDL 15.58 ± 18.07 mgdL−1). While the obese group showed significant decreases in the biomarkers in GCF (IL-1β 58.38 ± 65.55 pgmL−1, MMP-8 4.19 ± 5.61 ngmL−1, MMP-9 3.36 ± 6.30 ngmL−1), the mean changes for the normal weight group (IL-1β 10.07 ± 21.08 pgmL−1, MMP-8 1.49 ± 4.61 ngmL−1, MMP-9 -1.52 ± 9.71 ngmL−1) were not statistically significant. Anthropometric measures and the amounts of GCF biomarkers had weak positive correlations (0.242 ≤ r ≤ 0.340), and LDL in serum correlated with MMP-8 (r = 0.332) and IL-1β (r = 0.342) in the obese group. Stepwise multiple linear regression analysis in the obese group showed that the relationship between the amount of IL-1β in GCF and predictor variables including LDL and BMI was highly significant and accounted for 19.1 % of the variance in IL-1β in GCF.

Conclusions

In periodontally healthy subjects, weight control could reduce the amounts of MMP-8, MMP-9, and IL-1β in GCF of the obese subjects. Further studies with periodontally unhealthy and obese people are needed to identify the mechanism of decreases in inflammation biomarkers in GCF through weight control.

Trial registration

ISRCTN86753073 (2015.08.14)
Literatur
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