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Erschienen in: Rheumatology International 8/2012

01.08.2012 | Original Article

Changes and significance of IL-25 in chicken collagen II-induced experimental arthritis (CIA)

verfasst von: Wang Kaiwen, Su Zhaoliang, Zhao Yinxia, Sandoghchian Shotorbani Siamak, Jiao Zhijun, Xue Yuan, Yang Heng, Zheng Dong, Liu Yanfang, Shen Pei, Wang Shengjun, Shao Qixiang, Huang Xinxiang, Lu Liwei, Xu Huaxi

Erschienen in: Rheumatology International | Ausgabe 8/2012

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Abstract

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease. It is a systemic inflammatory disease, characterized by chronic, symmetrical, multi-articular synovial arthritis. IL-25 (IL-17E) is a member of the recently emerged cytokine family (IL-17s), which is expressed in Th2 cells and bone marrow-derived mast cells. Unlike the other members of this family, IL-25 is capable of inducing Th2-associated cytokines (IL-4, IL-5, and IL-13) and also promotes the release of some pro-immune factors (IL-6 and IL-8). IL-25 is also a pleiotropic factor, which constitutes a tissue-specific pathological injury and chronic inflammation. In this study, we used chicken collagen II-induced experimental arthritis (CIA) model in DBA/1 mice to investigate the relationship between IL-25 and other inflammatory factors, revealing the possible mechanism in CIA. Our results showed that the expression level of IL-25 was enhanced in the late stage of CIA, and IL-17 was increased in the early stage of the disease. It is well known that IL-17 has a crucial role in the development of RA pathogenesis, and IL-25 plays a significant role in humoral immune. For reasons given above, we suggested that the IL-25 inhibited IL-17 expression to some extent, while enhancing the production of IL-4. It was confirmed that IL-25 not only regulated the cellular immune, but also involved the humoral immune in rheumatoid arthritis.
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Metadaten
Titel
Changes and significance of IL-25 in chicken collagen II-induced experimental arthritis (CIA)
verfasst von
Wang Kaiwen
Su Zhaoliang
Zhao Yinxia
Sandoghchian Shotorbani Siamak
Jiao Zhijun
Xue Yuan
Yang Heng
Zheng Dong
Liu Yanfang
Shen Pei
Wang Shengjun
Shao Qixiang
Huang Xinxiang
Lu Liwei
Xu Huaxi
Publikationsdatum
01.08.2012
Verlag
Springer-Verlag
Erschienen in
Rheumatology International / Ausgabe 8/2012
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-011-1955-2

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