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Archives of Osteoporosis

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01.12.2019 | Review Article

Changes in femoral bone mineral density after total knee arthroplasty: a systematic review and meta-analysis

verfasst von: Joel M. Prince, James T. Bernatz, Neil Binkley, Matthew P. Abdel, Paul A. Anderson

Erschienen in: Archives of Osteoporosis | Ausgabe 1/2019

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Abstract

Background

Bone loss after total knee arthroplasty (TKA) may lead to periprosthetic fractures that are associated with significant costs (morbidity, economic, etc.) and pose a challenge to operative fixation. This meta-analysis quantifies the change in bone mineral density (BMD) of the distal femur after primary TKA.

Methods

A systematic review of six databases was performed by two independent reviewers. Studies that reported bone density after knee arthroplasty were identified and inclusion/exclusion criteria was applied. Data were extracted and analyzed using the Comprehensive Meta-Analysis Software.

Results

Fourteen studies were included in the analysis. The average decrease in BMD was 0.09 [0.05, 0.13], 0.14 [0.08, 0.20], 0.16 [0.10, 0.23], and 0.16 [0.12, 0.20] g/cm² at 3, 6, 12, and 24 months, respectively, corresponding to a 9.3%, 13.2%, 15.8%, and 15.4% BMD loss. A high degree of heterogeneity existed between the studies (I² > 90% at most time points).

Conclusion

In summary, there is a rapid and significant 15% decrease in BMD in the first 6 months after TKA that is sustained to 24 months. Better understanding regarding how perioperative optimization of bone health may affect BMD loss and the incidence of periprosthetic fracture is essential.

Level of evidence

Therapeutic Level II.

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Titel: Changes in femoral bone mineral density after total knee arthroplasty: a systematic review and meta-analysis
verfasst von: Joel M. Prince
James T. Bernatz
Neil Binkley
Matthew P. Abdel
Paul A. Anderson
Publikationsdatum: 01.12.2019
Verlag: Springer London
Erschienen in: Archives of Osteoporosis / Ausgabe 1/2019
Print ISSN: 1862-3522
Elektronische ISSN: 1862-3514
DOI: https://doi.org/10.1007/s11657-019-0572-7

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Springer Medizin

Changes in femoral bone mineral density after total knee arthroplasty: a systematic review and meta-analysis

Abstract

Background

Methods

Results

Conclusion

Level of evidence

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Abstract

Background

Methods

Results

Conclusion

Level of evidence

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