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Erschienen in: Anatomical Science International 3/2009

01.09.2009 | Original Article

Changes in postnatal skeletal muscle development induced by alternative immobilization model in female rat

verfasst von: Priscila Cação Benedini-Elias, Mariana Calvente Morgan, Anna Raquel Silveira Gomes, Ana Cláudia Mattiello-Sverzut

Erschienen in: Anatomical Science International | Ausgabe 3/2009

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Abstract

The objective of this study was to adapt a model of hind limb immobilization to newly weaned female rats and to determine the morphology of shortened soleus and plantaris muscles. Female Wistar rats were divided into three groups: control zero (n = 3) and control and free (n = 8), animals aged 21 and 31 days, respectively, submitted to no intervention, and immobilized (n = 25), animals aged 21 days submitted to immobilization for 10 days and sacrificed at 31 days of age. The device used for immobilization had advantages such as easy connection, good fit, and low cost. The immobilized rats showed a reduction in muscle fiber area and in connective tissue. The adaptation of this immobilization model originally used for adult rats was an excellent alternative for newly weaned rats and was also efficient in inducing significant hind limb disuse.
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Metadaten
Titel
Changes in postnatal skeletal muscle development induced by alternative immobilization model in female rat
verfasst von
Priscila Cação Benedini-Elias
Mariana Calvente Morgan
Anna Raquel Silveira Gomes
Ana Cláudia Mattiello-Sverzut
Publikationsdatum
01.09.2009
Verlag
Springer Japan
Erschienen in
Anatomical Science International / Ausgabe 3/2009
Print ISSN: 1447-6959
Elektronische ISSN: 1447-073X
DOI
https://doi.org/10.1007/s12565-009-0016-3

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