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European Journal of Clinical Microbiology & Infectious Diseases

Erschienen in:

28.04.2021 | Brief Report

Characteristics and outcome of varicella-zoster virus central nervous system infections in adults

verfasst von: A. Le Bot, A. Ballerie, C. Pronier, F. Bénézit, F. Reizine, M. Tas, P. Jégo, M. Revest, Y. Le Tulzo, P. Fillâtre, Pierre Tattevin

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 11/2021

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Abstract

We conducted an observational retrospective study of all adults hospitalized for documented varicella-zoster virus (VZV) meningitis or encephalitis during years 2000–2015 in one referral centre. Thirty-six patients (21 males, 15 females) were included, with meningitis (n = 21), or meningoencephalitis (n = 15). Median age was 51 years [interquartile range, 35–76], and 6 patients (17%) were immunocompromised. Aciclovir was started in 32 patients (89%), with a median dose of 11 mg/kg/8 h [10–15]. No patient died, but 12 (33%) had neurological sequelae at discharge. Age was the only variable associated with adverse outcome (OR 1.98 [1.17–3.35] per 10-year increment, P = 0.011).

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Titel: Characteristics and outcome of varicella-zoster virus central nervous system infections in adults
verfasst von: A. Le Bot
A. Ballerie
C. Pronier
F. Bénézit
F. Reizine
M. Tas
P. Jégo
M. Revest
Y. Le Tulzo
P. Fillâtre
Pierre Tattevin
Publikationsdatum: 28.04.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 11/2021
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-021-04245-y

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