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04.03.2019 | Invited review article | Ausgabe 6/2019 Open Access

Clinical and Experimental Nephrology 6/2019

Characteristics of coronary artery disease in chronic kidney disease

Clinical and Experimental Nephrology > Ausgabe 6/2019
Hideki Fujii, Keiji Kono, Shinichi Nishi
Wichtige Hinweise
This article was presented as the Clinical Scientist Award memorial lecture at the 61th annual meeting of the Japanese Society of Nephrology, held at Niigata, Japan in 2018.

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Patients with chronic kidney disease (CKD) commonly experience cardiovascular disease (CVD), and a major cause of death in these patients is CVD. Therefore, the prevention of CVD progression is very crucial in patients with CKD. Recently, this relationship between CKD and CVD has increasingly been examined, and a concept termed “cardiorenal syndrome” has been advocated. Coronary artery disease (CAD) and myocardial injury are crucial factors that contribute to the occurrence of CVD. The initial step CAD is endothelial dysfunction that can be detected as a decrease in the coronary flow reserve (CFR). The previous studies have reported that decreased CFR is significantly correlated to coronary events and mortality. Furthermore, CFR reduces with a decline in the kidney function. Another important presentation of CAD is coronary artery calcification. Vascular calcification is a crucial pathophysiological state, particularly in patients with CKD, and it affects the stability of coronary atherosclerotic plaque. In CKD, not only the traditional risk factors but also CKD-related non-traditional risk factors play key roles in CVD progression. Therefore, the mechanisms responsible for CVD progression are very complex; however, their clarification is crucial to improve the prognosis in patients with CKD.

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