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Erschienen in: International Ophthalmology 1/2018

31.03.2017 | Original Paper

Characteristics of orbital lymphoma: a clinicopathological study of 26 cases

verfasst von: Daniel Briscoe, Christine Safieh, Yokrat Ton, Hava Shapiro, Ehud I. Assia, Dvora Kidron

Erschienen in: International Ophthalmology | Ausgabe 1/2018

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Abstract

Objective

Evaluation of the medical data of patients with orbital and adnexal lymphoma.

Design

Cohort study of all cases diagnosed with orbital or adnexal lymphoma at Meir Medical Center between 1993 and 2007.

Participants

Twenty-six patients, with intraorbital or subconjunctival masses with orbital involvement, were examined and followed up between 1 and 8 years.

Materials and methods

Examined data included: clinical presentation, age, gender, imaging, tumor location, surgical management, and pathological diagnosis.

Results

Presenting signs and symptoms included proptosis, eyelid lesions, tearing, chemosis, decreased visual acuity, ptosis, pain, squint, and optic nerve compression. In five cases, lymphoma was misdiagnosed on neuroimaging. Bone changes were seen in four patients. All cases were B cell lymphomas; with the majority (22 cases) of small B cell type; consisting of primary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue and two cases of small cell lymphoma. One small cell lymphomas was of follicular type on a background of CLL, and the other was CLL/SLL type. Fourteen cases were primary orbital disease, and 12 cases were systemic disease. Macroscopic appearance of lymphoma at open biopsy was characteristic in most cases. Flow cytometry phenotyping gave rapid reliable diagnosis of the disease.

Conclusions

Epiphora or chemosis in the presence of an orbital mass should alert the ophthalmologist to suspect lymphoma. Lymphoma may be easily misinterpreted on neuroimaging for other diseases. Bone changes seen on CT are more common than is generally perceived. Macroscopic appearance at open biopsy was characteristic.
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Metadaten
Titel
Characteristics of orbital lymphoma: a clinicopathological study of 26 cases
verfasst von
Daniel Briscoe
Christine Safieh
Yokrat Ton
Hava Shapiro
Ehud I. Assia
Dvora Kidron
Publikationsdatum
31.03.2017
Verlag
Springer Netherlands
Erschienen in
International Ophthalmology / Ausgabe 1/2018
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-017-0457-y

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