Background
Methods
Samples
Histological evaluation
DNA extraction and tissue microarray construction
MED12 mutation analysis
Immunohistochemistry
Scoring of the TMAs
FH mutation analysis
Statistical analyses
Findings
Uterine smooth muscle tumor classification
Conventional leiomyomas
Smooth muscle tumor subtype | Total |
MED12 mutation positive |
HMGA2 overexpressing |
FH deficient | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | % |
P-value | 95% CI | N | % |
P-value | 95% CI | N | % |
P-value | 95% CI | ||
Conventional | 65 | 37 | 56.9 | 16 | 24.6 | 0 | 0 | ||||||
Histopathological UL variant | 94 | 17 | 18.1 | 5.2 × 10−7
| 2.76–13.14 | 13 | 13.8 | 0.10 | 0.83–5.01 | 8 | 8.5 | 0.02 | 0.00–0.81 |
Mitotically active | 25 | 9 | 36 | 0.10 | 0.83–6.93 | 1 | 4 | 0.03 | 1.07–341.56 | 0 | 0 | ||
Leiomyoma with bizarre nuclei | 18 | 3 | 16.7 | 3.0 × 10−3
| 1.61–38.18 | 0 | 0 | 0.02 | 1.24- ∞ | 6 | 33.3 | 4.9 × 10−5
| 0.00–0.19 |
Cellular | 25 | 4 | 16 | 7.3 × 10−4
| 1.98–30.31 | 8 | 32 | 0.60 | 0.23–2.23 | 1 | 4 | 0.28 | 0.00–15.00 |
Highly cellular | 37 | 3 | 8.1 | 6.0 × 10−7
| 3.98–81.73 | 4 | 10.8 | 0.12 | 0.77–11.96 | 1 | 2.7 | 0.36 | 0.00–22.20 |
Leiomyosarcoma | 51 | 11 | 21.6 | 1.4 × 10−4
| 1.96–12.16 | 3 | 5.9 | 0.01 | 1.35–29.40 | 2 | 3.9 | 0.19 | 0.00–4.16 |