S.aureus is a predominant pathogen that causes infection in critically ill patients, but little information exists regarding the characterization of S. aureus from different sources in burn patients in southeastern China.
We enrolled 125 patients with S. aureus infection in burns center between Jan 2014 and Dec 2015. S. aureus isolates were characterized by antimicrobial susceptibility test, toxin gene detection, and molecular typing with multilocus sequence type, staphylococcal protein A (spa) type, and staphylococcal cassette chromosome mec (SCCmec) type.
Sixty-eight MRSA were isolated from SSTI and 31 from non-SSTI patients, respectively. Overall, the drug-resistant ability of S. aureus isolated from SSTI was higher than that from non-SSTI groups. SCCmecIII-CC239-t030 was the most common clone (38 from SSTIs, and 8 from non-SSTIs). Seg was the most common enterotoxin gene (21 from SSTIs and 33 from non-SSTIs). Isolates from SSTIs was more likely to carry seb (P = 0.04), while those from non-SSTIs tended to carry sea and seg (P = 0.002 and 0.01, respectively). Although isolates carried four hemolysin genes, there was no significant difference between them (P > 0.05).
SCCmecIII-CC239-t030 was the most common clone in Jiangxi burns center, China. The molecular characterization of S. aureus was quite different between SSTI and non-SSTI groups.
Norbury W, Herndon DN, Tanksley J, Jeschke MG, Finnerty CC. Infection in burns. Surg Infect. 2016;17(2):250–5. CrossRef
Xie X, Bao Y, Ouyang N, Dai X, Pan K, Chen B, et al. Molecular epidemiology and characteristic of virulence gene of community-acquired and hospital-acquired methicillin-resistant Staphylococcus aureus isolates in sun Yat-sen memorial hospital, Guangzhou, southern China. BMC Infect Dis. 2016;16(339)
CLSI. Performance standards for antimicrobial susceptibility test: 24th informational supplement M100-S24. Clinical and laboratory standard institute. PA, USA: Wayne; 2014.
Gu FF, Han LZ, Chen X, Wang YC, Shen H, Wang JQ, et al. Molecular characterization of Staphylococcus Aureus from surgical site infections in orthopedic patients in an orthopedic trauma clinical medical center in shanghai. Surg Infect(Larchmt). 2015;16(1):97–104. CrossRef
Abdulgader SM, Shittu AO, Nicol MP, Kaba M. Molecular epidemiology of methicillin-resistant Staphylococcus aureus in Africa: a systematic review. Front Microbiol. 2015;6(348)
Baines SL, Holt KE, Schultz MB, Seemann T, Howden BO, Jensen SO, et al. Convergent adaptation in the dominant global hospital clone ST239 of methicillin-resistant Staphylococcus aureus. MBio, 2015; 6(2): e00080.
Ning X, Sun M, Qiao Y, Dong F, Song W, Yao K, et al. Characterization of pediatric hospital-associated infection caused by methicillin-resistant Staphylococcus aureus in mainland China. Infect Dis (lond). 2015;47(6):410–7. CrossRef
Changchien CH, Chen SW, Chen YY, Chu C. Antibiotic susceptibility and genomic variations in Staphylococcus aureus associated with skin and soft tissue infection (SSTI) disease groups. BMC Infect Dis. 2016;16(276)
Goudarzi M, Bahramian M, Satarzadeh Tabrizi M, Udo EE, Fiqueiredo AM, et al. Genetic diversity of methicillin resistant Staphylococcus Aureus strains isolated from burn patients in Iran: ST239-SCCmec/t037 emerges as the major clone. Micro Pathog. 2017;105:1–7. CrossRef
Liu Y, Zhang J, Zhong D, Ji L, Yang J, Philips J, et al. Characterization of Staphylococcus aureus isolates from pediatric patients with cystic fibrosis. World J Microbiol Biotechnol, 2016; 32(10): 162.
Yu F, Liu Y, Lv J, Lu C, Ding Y, Li D, et al. Antimicrobial susceptibility, virulence determinant carriage and molecular characteristics of Staphylococcus aureus isolates associated with skin and soft tissue infections. Braz J Infect Dis. 2015;9(6):614–22. CrossRef
- Characterization of Staphylococcus aureus isolated from patients with burns in a regional burn center, Southeastern China
- BioMed Central
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