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31.10.2017 | Original Article

Characterization of the neuraminidase genes from human influenza A viruses circulating in Iran from 2010 to 2015

verfasst von: Elham Moasser, Farida Behzadian, Afagh Moattari, Fatemeh Fotouhi, Hassan Zaraket

Erschienen in: Archives of Virology | Ausgabe 2/2018

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Abstract

Background

Characterization of influenza viruses is critical for detection of new emerging variants. Herein, we analyzed the genetic diversity and drug susceptibility of the neuraminidase gene (NAs) expressed by influenza A/H1N1pdm09 and A/H3N2 viruses circulating in Iran from 2010 to 2015.

Methods

We genetically analyzed the NAs of 38 influenza A/H1N1pdm09 and 35 A/H3N2 isolates.

Results

The Iranian A/H1N1pdm09 viruses belonged to seven genogroups/subgenogroups, with the dominant groups being genogroups 6B and 6C. The A/H3N2 isolates fell into six gneogroups/subgenogroups, with the dominant genogroups being 3C and 3C.2a. The most common mutations detected among the A/H1N1pdm09 viruses included N44S, V106I, N200S, and N248D. All H1N1pdm09 viruses were genetically susceptible to the NAIs. However, one A/H1N1pdm09 virus from the 2013–2014 season possessed an NA-S247N mutation, which reduces the susceptibility to oseltamivir. In case of H3N2, none of the analyzed Iranian strains carried a substitution that might affect its susceptibility to NAIs.

Conclusion

The ongoing evolution of influenza viruses and the detect of influenza viruses with reduced susceptibility to NAIs warrants continuous monitoring of the circulating strains.

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Palese P, Shaw M (2013) Orthomyxoviridae. In: Fields virology, 6th edn. Lippincott Williams and Wilkins, Philadelphia, PA, pp 1151–1185

Shi W, Lei F, Zhu C, Sievers F, Higgins DG (2011) A complete analysis of HA and NA genes of influenza A viruses. PLoS One 5:e14454CrossRef

World Health Organization (2009) Influenza (seasonal). Fact sheet no. 211. World Health Organization, Geneva, Switzerland. http://www.who.int/mediacentre/factsheets/fs211/en/index.html. Accessed 13 Apr 2016

Antón A, Pozo F, Niubó J, Casas I, Pumarola T (2012) Influenza A (H1N1) pdm09 virus: viral characteristics and genetic evolution. Enfermedades infecciosas y microbiologia clinica 30:10–17CrossRefPubMed

Medina RA, García-Sastre A (2011) Influenza A viruses: new research developments. Nat Rev Micro 9:590–603CrossRef

Loregian A, Mercorelli B, Nannetti G, Compagnin C, Palù G (2014) Antiviral strategies against influenza virus: towards new therapeutic approaches. Cell Mol Life Sci 71:3659–3683CrossRefPubMed

Hurt AC, Ernest J, Deng Y-M, Iannello P, Besselaar TG, Birch C et al (2009) Emergence and spread of oseltamivir-resistant A (H1N1) influenza viruses in Oceania, South East Asia and South Africa. Antiviral Res 83:90–93CrossRefPubMed

Zaraket H, Dapat C, Ghanem S, Ali Z, Lteif M, Kondo H et al (2014) Characterization of human influenza viruses in Lebanon during 2010–2011 and 2011–2012 post-pandemic seasons. Intervirology 57:344–352CrossRefPubMed

Ison MG (2011) Antivirals and resistance: influenza virus. Curr Opin Virol 1:563–573CrossRefPubMed

10.

Kamali A, Holodniy M (2013) Influenza treatment and prophylaxis with neuraminidase inhibitors: a review. Infect Drug Res 6:187–198

11.

McKimm-Breschkin JL (2013) Influenza neuraminidase inhibitors: antiviral action and mechanisms of resistance. Influenza Other Respir Viruses 7:25–36CrossRefPubMed

12.

Whitley RJ, Hayden FG, Reisinger KS, Young N, Dutkowski R, Ipe D et al (2001) Oral oseltamivir treatment of influenza in children. Pediatr Infect Dis J 20:127–133CrossRefPubMed

13.

Colman PM, Varghese J, Laver W (1983) Structure of the catalytic and antigenic sites in influenza virus neuraminidase. Nature 303:41–44CrossRefPubMed

14.

Sheu TG, Fry AM, Garten RJ, Deyde VM, Shwe T, Bullion L et al (2011) Dual resistance to adamantanes and oseltamivir among seasonal influenza A (H1N1) viruses: 2008–2010. J Infect Dis 203:13–17CrossRefPubMedPubMedCentral

15.

Hay AJ, Collins PJ, Russell RJ (2008) Antivirals and resistance. Avian influenza. Karger Publishers, Basel, pp 252–271CrossRef

16.

Garcia V, Aris-Brosou S (2014) Comparative dynamics and distribution of influenza drug resistance acquisition to protein m2 and neuraminidase inhibitors. Mol Biol Evol 31:355–363CrossRefPubMed

17.

Eshaghi A, Shalhoub S, Rosenfeld P, Li A, Higgins RR, Stogios PJ et al (2014) Multiple influenza A (H3N2) mutations conferring resistance to neuraminidase inhibitors in a bone marrow transplant recipient. Antimicrob Agents Chemother 58:7188–7197CrossRefPubMedPubMedCentral

18.

Moasser E, Behzadian F, Moattari A, Fotouhi F, Rahimi A, Zaraket H et al (2017) Molecular characterization and phylogenetic analysis of human influenza A viruses isolated in Iran during the 2014-2015 season. Arch Virol 162:1975–1984CrossRefPubMed

19.

Centers for Disease Control and Prevention (2009) CDC protocol of realtime RTPCR for influenza A(H1N1). http://www.who.int/csr/resources/publications/swineflu/CDCRealtimeRTPCR_SwineH1Assay-2009_20090430.pdf. Accessed 23 Apr 2015

20.

World Health Organization (2009) WHO information for laboratory diagnosis of pandemic (H1N1) 2009 virus in humans—revised. http://www.who.int/csr/resources/publications/swineflu/WHO_Diagnostic_RecommendationsH1N1_20090521.pdf. Accessed 23 June 2015

21.

Tamura K, Stecher G, Peterson D, Filipski A, Kumar S (2013) MEGA6: molecular evolutionary genetics analysis version 6.0. Mol Biol Evol 30:2725–2729CrossRefPubMedPubMedCentral

22.

McCauley J, Daniels R, Lin Y, Xiang Z, Gregory V, Whittaker L et al (2015) Report prepared for the WHO annual consultation on the composition of influenza vaccine for the Northern Hemisphere 2014/15. http://www.crick.ac.uk/media/221849/nimr-report-feb2014-web.pdf. Accessed 5 Oct 2015.

23.

The WHO GISRS antiviral susceptibility expert working group (AVWG) (2016) Summary of neuraminidase amino acid substitutions associated with reduced inhibition by neuraminidase inhibitors (NAI). http://www.who.int/influenza/gisrs_laboratory/antiviral_susceptibility/avwg2014_nai_substitution_table.pdf?ua=1. Accessed 21 Oct 2016

24.

European Centre for Disease Prevention and Control (ECDC) (2014) Influenza virus characterisation, summary Europe, November 2014. ECDC, Stockholm. http://www.ecdc.europa.eu/en/publications/Publications/ERLI-Net-report-November-2014.pdf. Accessed 7 Dec 2015

25.

Nelson M, Spiro D, Wentworth D, Beck E, Fan J, Ghedin E et al (2009) The early diversification of influenza A/H1N1pdm. PLoS Curr 1:RRN1126

26.

Mukherjee A, Nayak MK, Dutta S, Panda S, Satpathi BR, Chawla-Sarkar M (2016) Genetic Characterization of Circulating 2015 A(H1N1)pdm09 Influenza Viruses from Eastern India. PLoS One 11:e0168464CrossRefPubMedPubMedCentral

27.

Fry AM, Gubareva LV (2012) Understanding influenza virus resistance to antiviral agents; early warning signs for wider community circulation. J Infect Dis 206:145–147CrossRefPubMed

28.

LeGoff J, Rousset D, Abou-Jaoudé G, Scemla A, Ribaud P, Mercier-Delarue S et al (2012) I223R mutation in influenza A(H1N1)pdm09 neuraminidase confers reduced susceptibility to Oseltamivir and Zanamivir and enhanced resistance with H275Y. PLoS One 7:e37095CrossRefPubMedPubMedCentral

29.

Kaminski MM, Ohnemus A, Staeheli P, Rubbenstroth D (2013) Pandemic 2009 H1N1 influenza A virus carrying a Q136K mutation in the neuraminidase gene is resistant to zanamivir but exhibits reduced fitness in the guinea pig transmission model. J Virol 87:1912–1915CrossRefPubMedPubMedCentral

30.

Gupta MK (2015) Mutations in surface protein of swine flu: A major problem for H1N1 inhibitor. Asian J Biomed Pharm Sci 5:01

31.

Moscona A (2009) Global transmission of oseltamivir-resistant influenza. N Engl J Med 360:953–956CrossRefPubMed

32.

MRC National Institute for Medical Research. WHO Influenza Centre London (2013) Report prepared for the WHO annual consultation on the composition of influenza vaccine for the Southern Hemisphere 2013. https://www.crick.ac.uk/media/221897/interim_report_september_2012_2.pdf. Accessed 15 Feb 2013

33.

Abed Y, Baz M, Boivin G (2006) Impact of neuraminidase mutations conferring influenza resistance to neuraminidase inhibitors in the N1 and N2 genetic backgrounds. Antivir Ther 11:971PubMed

34.

Okomo-Adhiambo M, Demmler-Harrison GJ, Deyde VM, Sheu TG, Xu X, Klimov AI et al (2010) Detection of E119V and E119I mutations in influenza A (H3N2) viruses isolated from an immunocompromised patient: challenges in diagnosis of oseltamivir resistance. Antimicrob Agents Chemother 54:1834–1841CrossRefPubMedPubMedCentral

35.

Yen H-L, Hoffmann E, Taylor G, Scholtissek C, Monto AS, Webster RG et al (2006) Importance of neuraminidase active-site residues to the neuraminidase inhibitor resistance of influenza viruses. J Virol 80:8787–8795CrossRefPubMedPubMedCentral

36.

World Health Organization (2011) Review of the 2010-2011 winter influenza season, northern hemisphere. Wkly Epidemiol Rec 86:222–227

37.

World Health Organization (2012) Review of the 2011–2012 winter influenza season, northern hemisphere. Wkly Epidemiol Rec 87:233–240

38.

World Health Organization (2013) Review of the 2012–2013 winter influenza season, northern hemisphere. Wkly Epidemiol Rec 88:225–232

39.

World Health Organization (2014) Review of the 2013–2014 winter influenza season, northern hemisphere. Wkly Epidemiol Rec 89:245–256

40.

World Health Organization (2015) Review of the 2014–2015 influenza season in the northern hemisphere. Wkly Epidemiol Rec 90:281–296

41.

Khodadad N, Moattari A, Shamsi Shahr Abadi M, Kadivar MR, Sarvari J, Tavakoli F et al (2015) Prevalence of Influenza A(H1N1)pdm09 virus resistant to Oseltamivir in Shiraz, Iran, during 2012 - 2013. Jundishapur J Microbiol 8:e23690

42.

Butler J, Hooper KA, Petrie S, Lee R, Maurer-Stroh S, Reh L et al (2014) Estimating the fitness advantage conferred by permissive neuraminidase mutations in recent oseltamivir-resistant A (H1N1) pdm09 influenza viruses. PLoS Pathog 10:e1004065CrossRefPubMedPubMedCentral

43.

Takahashi T, Song J, Suzuki T, Kawaoka Y (2013) Mutations in NA that induced low pH-stability and enhanced the replication of pandemic (H1N1) 2009 influenza A virus at an early stage of the pandemic. PLoS One 8:e64439CrossRefPubMedPubMedCentral

44.

Hurt AC, Hardie K, Wilson NJ, Deng YM, Osbourn M, Leang SK et al (2012) Characteristics of a widespread community cluster of H275Y oseltamivir-resistant A(H1N1)pdm09 influenza in Australia. J Infect Dis 206:148–157CrossRefPubMedPubMedCentral

45.

Fang Q, Gao Y, Chen M, Guo X, Yang X, Wei L (2015) Molecular epidemiology and evolution of influenza A and B viruses during winter 2013–2014 in Beijing, China. Arch Virol 160:1083–1095CrossRefPubMed

46.

Korsun N, Angelova S, Gregory V, Daniels R, Georgieva I, McCauley J (2017) Antigenic and genetic characterization of influenza viruses circulating in Bulgaria during the 2015/2016 season. Infec Genet Evol 49:241–250CrossRef

47.

Su YC, Bahl J, Joseph U, Butt KM, Peck HA, Koay ES et al (2015) Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection. Nat Commun 6:7952

48.

Hurt A, Lee R, Leang S, Cui L, Deng Y, Phuah S et al (2011) Increased detection in Australia and Singapore of a novel influenza A (H1N1) 2009 variant with reduced oseltamivir and zanamivir sensitivity due to a S247N neuraminidase mutation. Euro Surveill 16:19884PubMed

49.

Tewawong N, Vichiwattana P, Korkong S, Klinfueng S, Suntronwong N, Thongmee T et al (2017) Evolution of the neuraminidase gene of seasonal influenza A and B viruses in Thailand between 2010 and 2015. PLoS One 12:e0175655CrossRefPubMedPubMedCentral

50.

Jagadesh A, Salam AAA, Zadeh VR, Krishnan A, Arunkumar G (2017) Molecular characterization of neuraminidase genes of influenza A(H3N2) viruses circulating in Southwest India from 2009 to 2013. Arch Virol 162:1887–1902

51.

Byarugaba DK, Ducatez MF, Erima B, Mworozi EA, Millard M, Kibuuka H et al (2011) Molecular epidemiology of influenza A/H3N2 viruses circulating in Uganda. PLoS One 6:e27803

52.

Zhong J, Liang L, Huang P, Zhu X, Zou L, Yu S et al (2013) Genetic mutations in influenza H3N2 viruses from a 2012 epidemic in Southern China. Virol J 10:345CrossRefPubMedPubMedCentral

53.

Lee HK, Tang JW-T, Loh TP, Hurt AC, Oon LL-E, Koay ES-C (2015) Molecular surveillance of antiviral drug resistance of influenza A/H3N2 virus in Singapore, 2009–2013. PLoS One 10:e0117822CrossRefPubMedPubMedCentral

54.

Radchenko L, Fesenko A, Mironenko A, Smutko O (2016) Comparative analysis of mutations in influenza viruses genes HA and NA, isolated during 2012-2015 years. Bulletin of Taras Shevchenko National University of Kyiv Series: Problems of Physiological Functions Regulation 20:57–61

55.

Suzuki Y (2006) Natural selection on the influenza virus genome. Mol Biol Evol 23:1902–1911CrossRefPubMed

Titel: Characterization of the neuraminidase genes from human influenza A viruses circulating in Iran from 2010 to 2015
verfasst von: Elham Moasser
Farida Behzadian
Afagh Moattari
Fatemeh Fotouhi
Hassan Zaraket
Publikationsdatum: 31.10.2017
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 2/2018
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-017-3603-y

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Characterization of the neuraminidase genes from human influenza A viruses circulating in Iran from 2010 to 2015

Abstract

Background

Methods

Results

Conclusion

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Abstract

Background

Methods

Results

Conclusion

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