Erschienen in:
06.07.2016 | Magnetic Resonance
Characterizing amide proton transfer imaging in haemorrhage brain lesions using 3T MRI
verfasst von:
Ha-Kyu Jeong, Kyunghwa Han, Jinyuan Zhou, Yansong Zhao, Yoon Seong Choi, Seung-Koo Lee, Sung Soo Ahn
Erschienen in:
European Radiology
|
Ausgabe 4/2017
Einloggen, um Zugang zu erhalten
Abstract
Objectives
The aim of this study was to characterize amide proton transfer (APT)-weighted signals in acute and subacute haemorrhage brain lesions of various underlying aetiologies.
Methods
Twenty-three patients with symptomatic haemorrhage brain lesions including tumorous (n = 16) and non-tumorous lesions (n = 7) were evaluated. APT imaging was performed and analyzed with magnetization transfer ratio asymmetry (MTR
asym
). Regions of interest were defined as the enhancing portion (when present), acute or subacute haemorrhage, and normal-appearing white matter based on anatomical MRI. MTR
asym
values were compared among groups and components using a linear mixed model.
Results
MTR
asym
values were 3.68 % in acute haemorrhage, 1.6 % in subacute haemorrhage, 2.65 % in the enhancing portion, and 0.38 % in normal white matter. According to the linear mixed model, the distribution of MTR
asym
values among components was not significantly different between tumour and non-tumour groups. MTR
asym
in acute haemorrhage was significantly higher than those in the other regions regardless of underlying pathology.
Conclusions
Acute haemorrhages showed high MTR
asym
regardless of the underlying pathology, whereas subacute haemorrhages showed lower MTR
asym
than acute haemorrhages. These results can aid in the interpretation of APT imaging in haemorrhage brain lesions.
Key Points
• Acute haemorrhages show significantly higher MTR
asym
values than subacute haemorrhages.
• MTR
asym
is higher in acute haemorrhage than in enhancing tumour tissue.
• MTR
asym
in haemorrhage does not differ between tumorous and non-tumorous lesions.