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27.10.2017 | Inflammatory Disorders

Checkpoint inhibitor-induced uveitis: a case series

verfasst von: Christopher D. Conrady, Marissa Larochelle, Paula Pecen, Alan Palestine, Akbar Shakoor, Ajay Singh

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 1/2018

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Abstract

Purpose

Checkpoint inhibitors are now a common treatment modality for metastatic cancer. In this manuscript, we describe the clinical features and management of autoimmune non-infectious uveitis induced by this class of drugs.

Methods

Seven patients undergoing checkpoint inhibitor treatment for metastatic cancer from uveitis practices at three tertiary referral centers.

Results

All seven patients developed various severities of ocular inflammatory disease while taking checkpoint inhibitors for metastatic disease.

Conclusions

Checkpoint inhibitors may induce autoimmune uveitis. Ocular complaints should prompt an early evaluation by an ophthalmologist.

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Titel: Checkpoint inhibitor-induced uveitis: a case series
verfasst von: Christopher D. Conrady
Marissa Larochelle
Paula Pecen
Alan Palestine
Akbar Shakoor
Ajay Singh
Publikationsdatum: 27.10.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 1/2018
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-017-3835-2

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Checkpoint inhibitor-induced uveitis: a case series

Abstract

Purpose

Methods

Results

Conclusions

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

Bestmögliche Wundheilung der Kornea dank optimaler pharmakologischer Therapie

Update Augenheilkunde

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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