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06.09.2019 | Note

Chemical constituents from Ginkgo biloba leaves and their cytotoxicity activity

verfasst von: Penghua Shu, Mengyuan Sun, Junping Li, Lingxiang Zhang, Haichang Xu, Yueyue Lou, Zhiyu Ju, Xialan Wei, Wenming Wu, Na Sun

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2020

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Abstract

One novel neoligan glucoside, Ginkgoside B (1), and one new glucose ester, 6-O-(4-hydroxyhydrocinnamoyl)-d-glucopyranose (2), along with nine known compounds (3–11) were isolated from the ethanol extract of Ginkgo biloba leaves. Their structures were elucidated by combination of spectroscopic analyses and alkaline methanolysis. The absolute configuration of compound 1 was determined by single-crystal X-ray diffraction. All the isolated compounds were evaluated for their cytotoxicity activities, and compound 11 exhibited IC₅₀ values of 36.20 and 58.95 μM against 5637 and HeLa cell lines, respectively.

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Titel: Chemical constituents from Ginkgo biloba leaves and their cytotoxicity activity
verfasst von: Penghua Shu
Mengyuan Sun
Junping Li
Lingxiang Zhang
Haichang Xu
Yueyue Lou
Zhiyu Ju
Xialan Wei
Wenming Wu
Na Sun
Publikationsdatum: 06.09.2019
Verlag: Springer Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 1/2020
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-019-01359-8

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Chemical constituents from Ginkgo biloba leaves and their cytotoxicity activity

Abstract

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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