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European Radiology

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03.09.2015 | Hepatobiliary-Pancreas

Chemical exchange saturation transfer (CEST) MR technique for in-vivo liver imaging at 3.0 tesla

verfasst von: Shu-Zhong Chen, Jing Yuan, Min Deng, Juan Wei, Jinyuan Zhou, Yì-Xiáng J. Wáng

Erschienen in: European Radiology | Ausgabe 6/2016

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Abstract

Purpose

To evaluate Chemical Exchange Saturation Transfer (CEST) MRI for liver imaging at 3.0-T.

Materials and methods

Images were acquired at offsets (n = 41, increment = 0.25 ppm) from −5 to 5 ppm using a TSE sequence with a continuous rectangular saturation pulse. Amide proton transfer-weighted (APTw) and GlycoCEST signals were quantified as the asymmetric magnetization transfer ratio (MTR_asym) at 3.5 ppm and the total MTR_asym integrated from 0.5 to 1.5 ppm, respectively, from the corrected Z-spectrum. Reproducibility was assessed for rats and humans. Eight rats were devoid of chow for 24 hours and scanned before and after fasting. Eleven rats were scanned before and after one-time CCl4 intoxication.

Results

For reproducibility, rat liver APTw and GlycoCEST measurements had 95 % limits of agreement of −1.49 % to 1.28 % and −0.317 % to 0.345 %. Human liver APTw and GlycoCEST measurements had 95 % limits of agreement of −0.842 % to 0.899 % and −0.344 % to 0.164 %. After 24 hours, fasting rat liver APTw and GlycoCEST signals decreased from 2.38 ± 0.86 % to 0.67 ± 1.12 % and from 0.34 ± 0.26 % to −0.18 ± 0.37 % respectively (p < 0.05). After CCl4 intoxication rat liver APTw and GlycoCEST signals decreased from 2.46 ± 0.48 % to 1.10 ± 0.77 %, and from 0.34 ± 0.23 % to −0.16 ± 0.51 % respectively (p < 0.05).

Conclusion

CEST liver imaging at 3.0-T showed high sensitivity for fasting as well as CCl4 intoxication.

Key Points

• CEST MRI of in-vivo liver was demonstrated at clinical 3 T field strength.

• After 24-hour fasting, rat liver APTw and GlycoCEST signals decreased significantly.

• After CCl4 intoxication both rat liver APTw and GlycoCEST signals decreased significantly.

• Good scan–rescan reproducibility of liver CEST MRI was shown in healthy volunteers.

Nur mit Berechtigung zugänglich

Wallace K, Burt AD, Wright MC (2008) Liver fibrosis. Biochem J 411:1–18CrossRefPubMed

Patel K, Shackel NA (2008) Current status of fibrosis markers. Curr Opin Gastroenterol 30:253–259CrossRef

Anania C, Pacifico L, Ferraro F, Olivero E, Chiesa C (2011) Aspartate transaminase to platelet ratio index (APRI) to assess liver fibrosis in patients with chronic liver disease. Hepat Mon 11:479–480PubMedPubMedCentral

Tatsumi C, Kudo M, Ueshima K, Kitai S, Takahashi S, Inoue T et al (2008) Noninvasive evaluation of hepatic fibrosis using serum fibrotic markers, transient elastography (FibroScan) and real-time tissue elastography. Intervirology 51:27–33CrossRefPubMed

Sy S, Huang S, Wang YX, Yu J, Ahuja AT, Zhang YT et al (2010) Terahertz spectroscopy of liver cirrhosis: investigating the origin of contrast. Phys Med Biol 55:7587–7596CrossRefPubMed

Ligabue G, Besutti G, Scaglioni R, Stentarelli C, Guaraldi G (2013) MR quantitative biomarkers of non-alcoholic fatty liver disease: technical evolutions and future trends. Quant Imaging Med Surg 3:192–195PubMedPubMedCentral

Janes CH, Lindor KD (1993) Outcome of patients hospitalized for complications after outpatient liver biopsy. Ann Intern Med 118:96–98CrossRefPubMed

Bravo AA, Sheth SG, Chopra S (2001) Liver biopsy. N Engl J Med 344:495–500CrossRefPubMed

Zhou J, Lal B, Wilson DA, Laterra J, van Zijl PCM (2003) Amide proton transfer (APT) contrast for imaging of brain tumors. Magn Reson Med 50:1120–1126CrossRefPubMed

10.

Zhou J, Payen J, Wilson DA, Traystman RJ, van Zijl PCM (2003) Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI. Nat Med 9:1085–1090CrossRefPubMed

11.

Yuan J, Chen S, King AD, Zhou J, Bhatia KS, Zhang Q et al (2014) Amide proton transfer-weighted imaging of the head and neck at 3 T: a feasibility study on healthy human subjects and patients with head and neck cancer. NMR Biomed 27:1239–1247CrossRefPubMedPubMedCentral

12.

Kim M, Chan Q, Anthony MP, Cheung KM, Samartzis D, Khong PL (2011) Assessment of glycosaminoglycan distribution in human lumbar intervertebral discs using chemical exchange saturation transfer at 3 T: feasibility and initial experience. NMR Biomed 24:1137–1144CrossRefPubMed

13.

Haneder S, Apprich SR, Schmitt B, Michaely HJ, Schoenberg SO, Friedrich KM et al (2013) Assessment of glycosaminoglycan content in intervertebral discs using chemical exchange saturation transfer at 3.0 Tesla: preliminary results in patients with low-back pain. Eur Radiol 23:861–868CrossRefPubMed

14.

van Zijl PC, Jones CK, Ren J, Malloy CR, Sherry AD (2007) MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST). Proc Natl Acad Sci U S A 104:4359–4364CrossRefPubMedPubMedCentral

15.

Cai K, Haris M, Singh A, Kogan F, Greenberg JH, Hariharan H et al (2012) Magnetic resonance imaging of glutamate. Nat Med 18:302–306CrossRefPubMedPubMedCentral

16.

Chan KW, McMahon MT, Kato Y, Liu G, Bulte JW, Bhujwalla ZM et al (2012) Natural D-glucose as a biodegradable MRI contrast agent for detecting cancer. Magn Reson Med 68:1764–1773CrossRefPubMedPubMedCentral

17.

Walker-Samuel S, Ramasawmy R, Torrealdea F, Rega M, Rajkumar V, Johnson SP et al (2013) In vivo imaging of glucose uptake and metabolism in tumors. Nat Med 19:1067–1072CrossRefPubMed

18.

Jones CK, Schlosser MJ, van Zijl PC, Pomper MG, Golay X, Zhou J (2006) Amide proton transfer imaging of human brain tumors at 3T. Magn Reson Med 56:585–592CrossRefPubMed

19.

Zhou J, Zhu H, Lim M, Blair L, Quinones-Hinojosa A, Messina SA et al (2013) Three-dimensional amide proton transfer MR imaging of gliomas: Initial experience and comparison with gadolinium enhancement. J Magn Reson Imaging 38:1119–1128CrossRefPubMed

20.

Zhou J, Hong X, Zhao X, Gao JH, Yuan J (2013) APT-weighted and NOE-weighted image contrasts in glioma with different RF saturation powers based on magnetization transfer ratio asymmetry analyses. Magn Reson Med 70:320–327CrossRefPubMed

21.

Ren J, Trokowski R, Zhang S, Malloy CR, Sherry AD (2008) Imaging the Tissue Distribution of Glucose in Livers Using A PARACEST Sensor. Magn Reson Med 60:1047–1055CrossRefPubMedPubMedCentral

22.

Sagiyama K, Zhang S, Dimitrov I, Sherry AD, Takahashi M (2014) In Vivo Monitoring of Liver Glycogen by Chemical Exchange Saturation Transfer Imaging (GlycoCEST) in Live Mice. Proc Int Soc Magn Reson Med 22:0762

23.

Bawden SJ, Mougin O, Hunter K, Marciani L, Gowland P (2014) Simultaneously Measuring Glycogen and Lipid Levels Using Localized CEST Spectroscopy at 3T. Proc Int Soc Magn Reson Med 22:3159

24.

Abe W, Ikejima K, Lang T, Okumura K, Enomoto N, Kitamura T et al (2007) Low molecular weight heparin prevents hepatic fibrogenesis caused by carbon tetrachloride in the rat. J Hepatol 46:286–294CrossRefPubMed

25.

Sun PZ, Zhou J, Sun W, Huang J, van Zijl PC (2005) Suppression of lipid artifacts in amide proton transfer (APT) imaging. Magn Reson Med 54:222–225CrossRefPubMed

26.

Lu J, Zhou J, Cai C, Cai S, Chen Z (2015) Observation of true and pseudo NOE signals using CEST-MRI and CEST-MRS sequences with and without lipid suppression. Magn Reson Med. 73:1615--22

27.

Deng M, Zhao F, Yuan J, Ahuja AT, Wang YX (2012) Liver T1ρ MRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence. Br J Radiol 85:e590–e595CrossRefPubMedPubMedCentral

28.

Zhao F, Yuan J, Deng M, Lu PX, Ahuja AT, Wang YX (2013) Further exploration of MRI techniques for liver T1rho quantification. Quant Imaging Med Surg 3:308–315PubMedPubMedCentral

29.

Wang YX, Yuan J, Chu ES, Go MY, Huang H, Ahuja AT et al (2011) T1rho MR imaging is sensitive to evaluate liver fibrosis: an experimental study in a rat biliary duct ligation model. Radiology 259:712–719CrossRefPubMed

30.

Wang YX, Yuan J (2014) Evaluation of liver fibrosis with T1ρ MR imaging. Quant Imaging Med Surg 4:152–155PubMedPubMedCentral

31.

Allkemper T, Sagmeister F, Cicinnati V, Beckebaum S, Kooijman H, Kanthak C et al (2014) Evaluation of Fibrotic Liver Disease with Whole-Liver T1ρ MR Imaging: A Feasibility Study at 1.5 T. Radiology 271:408–415CrossRefPubMed

32.

Mannelli L, Wilson GJ, Dubinsky TJ, Potter CA, Bhargava P, Cuevas C et al (2012) Assessment of the liver strain among cirrhotic and normal livers using tagged MRI. J Magn Reson Imaging 36:1490–1495CrossRefPubMed

33.

Salameh N, Larrat B, Abarca-Quinones J, Pallu S, Dorvillius I, Leclercq I et al (2009) Early detection of steatohepatitis in fatty rat liver by using MR elastography. Radiology 253:90–97CrossRefPubMed

34.

Bonekamp S, Kamel I, Solga S, Clark J (2009) Can imaging modalities diagnose and stage hepatic fibrosis and cirrhosis accurately? J Hepatol 50:17–35CrossRefPubMed

35.

Lu PX, Huang H, Yuan J, Zhao F, Chen ZY, Zhang Q et al (2014) Decreases in Molecular Diffusion, Perfusion Fraction and Perfusion-Related Diffusion in Fibrotic Livers: A Prospective Clinical Intravoxel Incoherent Motion MR Imaging Study. PLoS One 9:e113846CrossRefPubMedPubMedCentral

36.

Yoon JH, Lee JM, Baek JH, Shin CI, Kiefer B, Han JK et al (2014) Evaluation of hepatic fibrosis using intravoxel incoherent motion in diffusion-weighted liver MRI. J Comput Assist Tomogr 38:110–116CrossRefPubMed

37.

Constandinou C, Henderson N, Iredale JP (2005) Modeling liver fibrosis in rodents. Methods Mol Med 117:237–250PubMed

38.

Marques TG, Chaib E, da Fonseca JH, Lourenço AC, Silva FD, Ribeiro MA Jr et al (2012) Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection. Acta Cir Bras 27:589–594CrossRefPubMed

39.

Muriel P (1998) Nitric oxide protection of rat liver from lipid peroxidation, collagen accumulation, and liver damage induced by carbon tetrachloride-Physiology, pathophysiology and pharmacology. Biochem Pharmacol 56:773–779CrossRefPubMed

40.

Pagadala M, Kasumov T, McCullough AJ, Zein NN, Kirwan JP (2012) Role of ceramides in nonalcoholic fatty liver disease. Trends Endocrinol Metab 23:365–371CrossRefPubMedPubMedCentral

41.

Jones CK, Huang A, Xu J, Edden RA, Schar M, Hua J et al (2013) Nuclear Overhauser enhancement (NOE) imaging in the human brain at 7T. Neuroimage 77:114–124CrossRefPubMed

42.

Jin T, Wang P, Zong X, Kim SG (2013) MR imaging of the amide-proton transfer effect and the pH-insensitive nuclear over hauser effect at 9.4 T. Magn Reson Med 69:760–770CrossRefPubMedPubMedCentral

43.

Li L, Tang X, Taylor KG, DuPré DB, Yappert MC (2002) Conformational characterization of ceramides by nuclear magnetic resonance spectroscopy. Biophys J 82:2067–2080CrossRefPubMedPubMedCentral

44.

Ichi I, Nakahara K, Fujii K, Iida C, Miyashita Y, Kojo S (2007) Increase of ceramide in the liver and plasma after carbon tetrachloride intoxication in the rat. J Nutr Sci Vitaminol (Tokyo) 53:53–56CrossRef

45.

Ling W, Regatte RR, Navon G, Jerschow A (2008) Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST). Proc Natl Acad Sci U S A 105:2266–2270CrossRefPubMedPubMedCentral

46.

Heo HY, Zhang Y, Lee DH, Hong X, Zhou J (2015) Quantitative assessment of amide proton transfer (APT) and nuclear Overhauser enhancement (NOE) imaging with extrapolated semi-solid magnetization transfer reference (EMR) signals: Application to a rat glioma model at 4.7 T. Magn Reson Med. doi:10.1002/mrm.25581

47.

Chow AM, Gao DS, Fan SJ, Qiao Z, Lee FY, Yang J et al (2012) Measurement of liver T1 and T2 relaxation times in an experimental mouse model of liver fibrosis. J Magn Reson Imaging 36:152–158CrossRefPubMed

48.

Stancanello J, Terreno E, Castelli DD, Cabella C, Uggeri F, Aime S (2008) (2008) Development and validation of a smoothing-splines-based correction method for improving the analysis of CEST-MR images. Contrast Media Mol Imaging 3:136–149CrossRefPubMed

49.

Kim M, Gillen J, Landman BA, Zhou J, van Zijl P (2009) Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments. Magn Reson Med 61:1441–1450CrossRefPubMedPubMedCentral

50.

Sun PZ, Benner T, Kumar A, Sorensen AG (2008) Investigation of optimizing and translating pH-sensitive pulsed-chemical exchange saturation transfer (CEST) imaging to a 3T clinical scanner. Magn Reson Med 60:834–841CrossRefPubMed

51.

Zaiss M, Schmitt B, Bachert P (2011) Quantitative separation of CEST effect from magnetization transfer and spillover effects by Lorentzian-line-fit analysis of z-spectra. J Magn Reson 211:149–155CrossRefPubMed

52.

Chappell MA, Donahue MJ, Tee YK, Khrapitchev AA, Sibson NR, Jezzard P et al (2013) Quantitative Bayesian model-based analysis of amide proton transfer MRI. Magn Reson Med 70:556–567CrossRefPubMed

53.

Zaiss M, Xu J, Goerke S, Khan IS, Singer RJ, Gore JC et al (2014) Inverse Z-spectrum analysis for spillover-, MT-, and T1-corrected steady-state pulsed CEST-MRI - application to pH-weighted MRI of acute stroke. NMR Biomed 27:240–252CrossRefPubMedPubMedCentral

54.

Zhao F, Deng M, Yuan J, Teng GJ, Ahuja AT, Wang YX (2012) Experimental evaluation of accelerated T1rho relaxation quantification in human liver using limited spin-lock times. Korean J Radiol 13:736–742CrossRefPubMedPubMedCentral

55.

Wang YX, Zhao F, Yuan J, Mok GS, Ahuja AT, Griffith JF (2013) Accelerated T1rho relaxation quantification in intervertebral disc using limited spin-lock times. Quant Imaging Med Surg 3:54–58PubMedPubMedCentral

56.

Yuan J, Zhao F, Griffith JF, Chan Q, Wang YX (2012) Optimized efficient liver T(1ρ) mapping using limited spin lock times. Phys Med Biol 57:1631–1640CrossRefPubMed

57.

Zhu Y, Zhang Q, Liu Q, Wang YX, Liu X, Zheng H et al (2015) PANDA- T1ρ: Integrating principal component analysis and dictionary learning for fast T1ρ mapping. Magn Reson Med. 73:263–272

58.

Sun PZ, Wang E, Cheung JS, Zhang X, Benner T, Sorensen AG (2011) Simulation and optimization of pulsed radio frequency (RF) irradiation scheme for chemical exchange saturation transfer (CEST) MRI - demonstration of pH-weighted pulsed-amide proton CEST MRI in an animal model of acute cerebral ischemia. Magn Reson Med 66:1042–1048CrossRefPubMedPubMedCentral

59.

Zu Z, Li K, Janve VA, Does MD, Gochberg DF (2011) Optimizing Pulsed-Chemical Exchange Saturation Transfer (CEST) Imaging Sequences. Magn Reson Med 66:1100–1108CrossRefPubMedPubMedCentral

Titel: Chemical exchange saturation transfer (CEST) MR technique for in-vivo liver imaging at 3.0 tesla
verfasst von: Shu-Zhong Chen
Jing Yuan
Min Deng
Juan Wei
Jinyuan Zhou
Yì-Xiáng J. Wáng
Publikationsdatum: 03.09.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 6/2016
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-3972-0

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Chemical exchange saturation transfer (CEST) MR technique for in-vivo liver imaging at 3.0 tesla

Abstract

Purpose

Materials and methods

Results

Conclusion

Key Points

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Abstract

Purpose

Materials and methods

Results

Conclusion

Key Points

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