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Erschienen in: Uro-News 12/2019

29.11.2019 | Zytostatische Therapie | Fortbildung

TIGER und die Hintergründe

Was tun beim Hodenkarzinomrezidiv nach Chemotherapie?

verfasst von: Dr. med. Annette Dieing

Erschienen in: Uro-News | Ausgabe 12/2019

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Zusammenfassung

Nach Erstdiagnose Hodenkarzinom werden nahezu alle Patienten in den frühen und der überwiegende Anteil der Patienten in den fortgeschrittenen Stadien geheilt. Im seltenen Fall des Rezidivs ist die optimale Therapie nicht eindeutig. Die Datenlage, aktuelle Empfehlungen und die zu dieser Frage laufende internationale TIGER-Studie sollen hier diskutiert werden.
Literatur
1.
Zurück zum Zitat Fischer et al. Outcome of Men With Relapse After Adjuvant Carboplatin for Clinical Stage I Seminoma. J Clin Oncol. 2017; 35: 194–200CrossRef Fischer et al. Outcome of Men With Relapse After Adjuvant Carboplatin for Clinical Stage I Seminoma. J Clin Oncol. 2017; 35: 194–200CrossRef
2.
Zurück zum Zitat International Prognostic Factors Study Group. Prognostic factors in patients with metastatic germ cell tumors who experienced treatment failure with cisplatin-based first-line chemotherapy. J Clin Oncol. 2010; 28: 4906-11 International Prognostic Factors Study Group. Prognostic factors in patients with metastatic germ cell tumors who experienced treatment failure with cisplatin-based first-line chemotherapy. J Clin Oncol. 2010; 28: 4906-11
3.
Zurück zum Zitat Adra et al. High-Dose Chemotherapy and Autologous Peripheral-Blood Stem-Cell Transplantation for Relapsed Metastatic Germ Cell Tumors: The Indiana University Experience. J Clin Oncol. 2016; 35: 1096–102CrossRef Adra et al. High-Dose Chemotherapy and Autologous Peripheral-Blood Stem-Cell Transplantation for Relapsed Metastatic Germ Cell Tumors: The Indiana University Experience. J Clin Oncol. 2016; 35: 1096–102CrossRef
4.
Zurück zum Zitat Pico et al. A randomised trial of high-dose chemotherapy in the salvage treatment of patients failing first-line platinum chemotherapy for advanced germ cell tumours. Ann Oncol. 2005; 16: 1152–9CrossRef Pico et al. A randomised trial of high-dose chemotherapy in the salvage treatment of patients failing first-line platinum chemotherapy for advanced germ cell tumours. Ann Oncol. 2005; 16: 1152–9CrossRef
5.
Zurück zum Zitat Lorch J et al. Conventional-dose versus high-dose chemotherapy as first salvage treatment in male patients with metastatic germ cell tumors: evidence from a large international database. Clin Oncol. 2011; 29: 2178–84CrossRef Lorch J et al. Conventional-dose versus high-dose chemotherapy as first salvage treatment in male patients with metastatic germ cell tumors: evidence from a large international database. Clin Oncol. 2011; 29: 2178–84CrossRef
6.
Zurück zum Zitat Feldmann DR et al. Is high dose therapy superior to conventional dose therapy as initial treatment for relapsed germ cell tumors? The TIGER Trial. J Cancer. 2011; 2: 374–7CrossRef Feldmann DR et al. Is high dose therapy superior to conventional dose therapy as initial treatment for relapsed germ cell tumors? The TIGER Trial. J Cancer. 2011; 2: 374–7CrossRef
7.
Zurück zum Zitat Cathomas R et al. Questioning the Value of Fluorodeoxyglucose Positron Emission Tomography for Residual Lesions After Chemotherapy for Metastatic Seminoma: Results of an International Global Germ Cell Cancer Group Registry. J Clin Oncol. https://doi.org/10.1200/JCO.18.00210CrossRef Cathomas R et al. Questioning the Value of Fluorodeoxyglucose Positron Emission Tomography for Residual Lesions After Chemotherapy for Metastatic Seminoma: Results of an International Global Germ Cell Cancer Group Registry. J Clin Oncol. https://​doi.​org/​10.​1200/​JCO.​18.​00210CrossRef
8.
Zurück zum Zitat Feldmann DR. Brain Metastases in Patients With Germ Cell Tumors: Prognostic Factors and Treatment Options—An Analysis From the Global Germ Cell Cancer Group. J Clin Oncol. 2016; 34: 345–51CrossRef Feldmann DR. Brain Metastases in Patients With Germ Cell Tumors: Prognostic Factors and Treatment Options—An Analysis From the Global Germ Cell Cancer Group. J Clin Oncol. 2016; 34: 345–51CrossRef
9.
Zurück zum Zitat Sharp DS et al. Clinical outcome and predictors of survival in late relapse of germ cell tumor. J Clin Oncol. 2008; 26: 5524–9CrossRef Sharp DS et al. Clinical outcome and predictors of survival in late relapse of germ cell tumor. J Clin Oncol. 2008; 26: 5524–9CrossRef
Metadaten
Titel
TIGER und die Hintergründe
Was tun beim Hodenkarzinomrezidiv nach Chemotherapie?
verfasst von
Dr. med. Annette Dieing
Publikationsdatum
29.11.2019
Verlag
Springer Medizin
Erschienen in
Uro-News / Ausgabe 12/2019
Print ISSN: 1432-9026
Elektronische ISSN: 2196-5676
DOI
https://doi.org/10.1007/s00092-019-3017-0

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