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2020 | Chemotherapie | OriginalPaper | Buchkapitel

34. Onkologika

verfasst von: Prof. Dr. med. Wolf-Dieter Ludwig, Prof. em. Dr. med. Ulrich Schwabe

Erschienen in: Arzneiverordnungs-Report 2020

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Auf einen Blick

Verordnungsprofil Das höchste Verordnungsvolumen unter den Onkologika haben weiterhin Hormonantagonisten zur Behandlung des Mammakarzinoms und des Prostatakarzinoms, auf die 65 % der definierten Tagesdosen (DDD) entfallen. An zweiter Stelle stehen die klassischen Zytostatika mit der führenden Gruppe der Antimetabolite, was vor allem auf den häufigen Verordnungen von 5-Fluorouracil beruht. Als nächste Gruppen folgen monoklonale Antikörper und Proteinkinaseinhibitoren. Führende Gruppen der monoklonalen Antikörper sind weiterhin die HER2-Antikörper zur Behandlung des HER2-positiven Mammakarzinoms gefolgt von Antikörpern gegen PD-1-Rezeptoren und PD-L1-Liganden, die für ein stetig wachsendes Spektrum von onkologischen Indikationen zugelassen sind. Führende Vertreter der Proteinkinaseinhibitoren sind die CDK4/6-Inhibitoren für die Behandlung des hormonrezeptorpositiven, fortgeschrittenen Mammakarzinoms, obwohl die Nutzenbewertung bisher keinen Zusatznutzen ergeben hat. Weitere Proteinkinaseinhibitoren werden zur Behandlung der chronischen myeloischen Leukämie, der chronischen lymphatischen Leukämie, der primären Myelofibrose, des nicht-kleinzelligen Lungenkarzinoms, des Nierenzellkarzinoms, des Melanoms, des kolorektalen Karzinoms und des Mammakarzinoms eingesetzt.
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Zurück zum Zitat Cuzick J, Sestak I, Baum M, Buzdar A, Howell A, Dowsett M, Forbes JF, ATAC/LATTE investigators (2010) Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 10-year analysis of the ATAC trial. Lancet Oncol 11:1135–1141 PubMed Cuzick J, Sestak I, Baum M, Buzdar A, Howell A, Dowsett M, Forbes JF, ATAC/LATTE investigators (2010) Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 10-year analysis of the ATAC trial. Lancet Oncol 11:1135–1141 PubMed
Zurück zum Zitat Davis ID, Martin AJ, Stockler MR, Begbie S, Chi KN, Chowdhury S, Coskinas X, Frydenberg M, Hague WE, Horvath LG, Joshua AM, Lawrence NJ, Marx G, McCaffrey J, McDermott R, McJannett M, North SA, Parnis F, Parulekar W, Pook DW, Reaume MN, Sandhu SK, Tan A, Tan TH, Thomson A, Tu E, Vera-Badillo F, Williams SG, Yip S, Zhang AY, Zielinski RR, Sweeney CJ, ENZAMET Trial Investigators and the Australian and New Zealand Urogenital and Prostate Cancer Trials Group (2019) Enzalutamide with standard first-line therapy in metastatic prostate cancer. N Engl J Med 381:121–131 PubMed Davis ID, Martin AJ, Stockler MR, Begbie S, Chi KN, Chowdhury S, Coskinas X, Frydenberg M, Hague WE, Horvath LG, Joshua AM, Lawrence NJ, Marx G, McCaffrey J, McDermott R, McJannett M, North SA, Parnis F, Parulekar W, Pook DW, Reaume MN, Sandhu SK, Tan A, Tan TH, Thomson A, Tu E, Vera-Badillo F, Williams SG, Yip S, Zhang AY, Zielinski RR, Sweeney CJ, ENZAMET Trial Investigators and the Australian and New Zealand Urogenital and Prostate Cancer Trials Group (2019) Enzalutamide with standard first-line therapy in metastatic prostate cancer. N Engl J Med 381:121–131 PubMed
Zurück zum Zitat Der Arzneimittelbrief (2018) Multiples Myelom: Das Zeitalter der Immuntherapie hat begonnen. AMB 52:9 Der Arzneimittelbrief (2018) Multiples Myelom: Das Zeitalter der Immuntherapie hat begonnen. AMB 52:9
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Zurück zum Zitat Der Arzneimittelbrief (2020) Ibrutinib: neue Erkenntnisse zu kardiovaskulräen Nebenwirkungen unter „Real-World“-Bedingungen. AMB 54:1 Der Arzneimittelbrief (2020) Ibrutinib: neue Erkenntnisse zu kardiovaskulräen Nebenwirkungen unter „Real-World“-Bedingungen. AMB 54:1
Zurück zum Zitat Deutsche Krebsgesellschaft e.V., Deutschen Krebshilfe, Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e.V. (2018) Interdisziplinäre S3-Leitlinie für die Früherkennung, Diagnostik, Therapie und Nachsorge des Mammakarzinoms Kurzversion 4.1 – September 2018, AWMF-Registernummer: 032-045OL. http://​www.​leitlinienprogra​mm-onkologie.​de/​leitlinien/​mammakarzinom/​ (Federführende Fachgesellschaften Deutsche Gesellschaft für Gynäkologie und Geburtshilfe (DGGG), Deutsche Krebsgesellschaft (DKG)) Deutsche Krebsgesellschaft e.V., Deutschen Krebshilfe, Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e.V. (2018) Interdisziplinäre S3-Leitlinie für die Früherkennung, Diagnostik, Therapie und Nachsorge des Mammakarzinoms Kurzversion 4.1 – September 2018, AWMF-Registernummer: 032-045OL. http://​www.​leitlinienprogra​mm-onkologie.​de/​leitlinien/​mammakarzinom/​ (Federführende Fachgesellschaften Deutsche Gesellschaft für Gynäkologie und Geburtshilfe (DGGG), Deutsche Krebsgesellschaft (DKG))
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Zurück zum Zitat Dimopoulos MA, Goldschmidt H, Niesvizky R, Joshua D, Chng WJ, Oriol A, Orlowski RZ, Ludwig H, Facon T, Hajek R, Weisel K, Hungria V, Minuk L, Feng S, Zahlten-Kumeli A, Kimball AS, Moreau P (2017a) Carfilzomib or bortezomib in relapsed or refractory multiple myeloma (ENDEAVOR): an interim overall survival analysis of an open-label, randomised, phase 3 trial. Lancet Oncol 18:1327–1337 PubMed Dimopoulos MA, Goldschmidt H, Niesvizky R, Joshua D, Chng WJ, Oriol A, Orlowski RZ, Ludwig H, Facon T, Hajek R, Weisel K, Hungria V, Minuk L, Feng S, Zahlten-Kumeli A, Kimball AS, Moreau P (2017a) Carfilzomib or bortezomib in relapsed or refractory multiple myeloma (ENDEAVOR): an interim overall survival analysis of an open-label, randomised, phase 3 trial. Lancet Oncol 18:1327–1337 PubMed
Zurück zum Zitat Dimopoulos MA, Lonial S, White D, Moreau P, Palumbo A, San-Miguel J, Shpilberg O, Anderson K, Grosicki S, Spicka I, Walter-Croneck A, Magen H, Mateos MV, Belch A, Reece D, Beksac M, Bleickardt E, Poulart V, Sheng J, Sy O, Katz J, Singhal A, Richardson P (2017b) Elotuzumab plus lenalidomide/dexamethasone for relapsed or refractory multiple myeloma: ELOQUENT-2 follow-up and post-hoc analyses on progression-free survival and tumour growth. Br J Haematol 178:896–905 PubMedPubMedCentral Dimopoulos MA, Lonial S, White D, Moreau P, Palumbo A, San-Miguel J, Shpilberg O, Anderson K, Grosicki S, Spicka I, Walter-Croneck A, Magen H, Mateos MV, Belch A, Reece D, Beksac M, Bleickardt E, Poulart V, Sheng J, Sy O, Katz J, Singhal A, Richardson P (2017b) Elotuzumab plus lenalidomide/dexamethasone for relapsed or refractory multiple myeloma: ELOQUENT-2 follow-up and post-hoc analyses on progression-free survival and tumour growth. Br J Haematol 178:896–905 PubMedPubMedCentral
Zurück zum Zitat Dobbelstein M, Moll U (2014) Targeting tumour-supportive cellular machineries in anticancer drug development. Nat Rev Drug Discov 13:179–196 PubMed Dobbelstein M, Moll U (2014) Targeting tumour-supportive cellular machineries in anticancer drug development. Nat Rev Drug Discov 13:179–196 PubMed
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Zurück zum Zitat Douillard JY, Siena S, Cassidy J, Tabernero J, Burkes R, Barugel M, Humblet Y, Bodoky G, Cunningham D, Jassem J, Rivera F, Kocákova I, Ruff P, Błasińska-Morawiec M, Šmakal M, Canon JL, Rother M, Oliner KS, Wolf M, Gansert J (2010) Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. J Clin Oncol 28:4697–4705 PubMed Douillard JY, Siena S, Cassidy J, Tabernero J, Burkes R, Barugel M, Humblet Y, Bodoky G, Cunningham D, Jassem J, Rivera F, Kocákova I, Ruff P, Błasińska-Morawiec M, Šmakal M, Canon JL, Rother M, Oliner KS, Wolf M, Gansert J (2010) Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. J Clin Oncol 28:4697–4705 PubMed
Zurück zum Zitat Douillard JY, Oliner KS, Siena S, Tabernero J, Burkes R, Barugel M, Humblet Y, Bodoky G, Cunningham D, Jassem J, Rivera F, Kocákova I, Ruff P, Błasińska-Morawiec M, Šmakal M, Canon JL, Rother M, Williams R, Rong A, Wiezorek J, Sidhu R, Patterson SD (2013) Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med 369:1023–1034 PubMed Douillard JY, Oliner KS, Siena S, Tabernero J, Burkes R, Barugel M, Humblet Y, Bodoky G, Cunningham D, Jassem J, Rivera F, Kocákova I, Ruff P, Błasińska-Morawiec M, Šmakal M, Canon JL, Rother M, Williams R, Rong A, Wiezorek J, Sidhu R, Patterson SD (2013) Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med 369:1023–1034 PubMed
Zurück zum Zitat Dreger P, Ghia P, Schetelig J, van Gelder M, Kimby E, Michallet M, Moreno C, Robak T, Stilgenbauer S, Montserrat E, European Research Initiaitve on CLL (ERIC) and the european Society for Blood and Marrow Transplantation (EBMT) (2018) High-risk chronic lymphocytic leukemia in the era of pathway inhibitors: integrating molecular and cellular therapies. Blood 132(9):892–902 PubMed Dreger P, Ghia P, Schetelig J, van Gelder M, Kimby E, Michallet M, Moreno C, Robak T, Stilgenbauer S, Montserrat E, European Research Initiaitve on CLL (ERIC) and the european Society for Blood and Marrow Transplantation (EBMT) (2018) High-risk chronic lymphocytic leukemia in the era of pathway inhibitors: integrating molecular and cellular therapies. Blood 132(9):892–902 PubMed
Zurück zum Zitat Durie BGM, Hoering A, Abidi MH, Rajkumar SV, Epstein J, Kahanic SP, Thakuri M, Reu F, Reynolds CM, Sexton R, Orlowski RZ, Barlogie B, Dispenzieri A (2017) Bortezomib with lenalidomide and dexamethasone versus lenalidomide and dexamethasone alone in patients with newly diagnosed myeloma without intent for immediate autologous stem-cell transplant (SWOG S0777): a randomised, open-label, phase 3 trial. Lancet 389:519–527 PubMed Durie BGM, Hoering A, Abidi MH, Rajkumar SV, Epstein J, Kahanic SP, Thakuri M, Reu F, Reynolds CM, Sexton R, Orlowski RZ, Barlogie B, Dispenzieri A (2017) Bortezomib with lenalidomide and dexamethasone versus lenalidomide and dexamethasone alone in patients with newly diagnosed myeloma without intent for immediate autologous stem-cell transplant (SWOG S0777): a randomised, open-label, phase 3 trial. Lancet 389:519–527 PubMed
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Zurück zum Zitat Ellis MJ, Llombart-Cussac A, Feltl D, Dewar JA, Jasiówka M, Hewson N, Rukazenkov Y, Robertson JF (2015) Fulvestrant 500 mg versus anastrozole 1 mg for the first-line treatment of advanced breast cancer: overall survival analysis from the phase II FIRST study. J Clin Oncol 33:3781–3787 PubMedPubMedCentral Ellis MJ, Llombart-Cussac A, Feltl D, Dewar JA, Jasiówka M, Hewson N, Rukazenkov Y, Robertson JF (2015) Fulvestrant 500 mg versus anastrozole 1 mg for the first-line treatment of advanced breast cancer: overall survival analysis from the phase II FIRST study. J Clin Oncol 33:3781–3787 PubMedPubMedCentral
Zurück zum Zitat Ernst E, Schmidt K, Steuer-Vogt MK (2003) Mistletoe for cancer? A systematic review of randomised clinical trials. Int J Cancer 107:262–267 PubMed Ernst E, Schmidt K, Steuer-Vogt MK (2003) Mistletoe for cancer? A systematic review of randomised clinical trials. Int J Cancer 107:262–267 PubMed
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Zurück zum Zitat Finn RS, Martin M, Rugo HS, Jones S, Im SA, Gelmon K, Harbeck N, Lipatov ON, Walshe JM, Moulder S, Gauthier E, Lu DR, Randolph S, Diéras V, Slamon DJ (2016) Palbociclib and letrozole in advanced breast cancer. N Engl J Med 375:1925–1936 PubMed Finn RS, Martin M, Rugo HS, Jones S, Im SA, Gelmon K, Harbeck N, Lipatov ON, Walshe JM, Moulder S, Gauthier E, Lu DR, Randolph S, Diéras V, Slamon DJ (2016) Palbociclib and letrozole in advanced breast cancer. N Engl J Med 375:1925–1936 PubMed
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Zurück zum Zitat Gadgeel S, Rodríguez-Abreu D, Speranza G, Esteban E, Felip E, Dómine M, Hui R, Hochmair MJ, Clingan P, Powell SF, Cheng SY, Bischoff HG, Peled N, Grossi F, Jennens RR, Reck M, Garon EB, Novello S, Rubio-Viqueira B, Boyer M, Kurata T, Gray JE, Yang J, Bas T, Pietanza MC, Garassino MC (2020) Updated analysis from KEYNOTE-189: pembrolizumab or placebo plus pemetrexed and platinum 2020 for previously untreated metastatic nonsquamous non-small-cell lung cancer. J Clin Oncol 38(14):1505–1517 PubMed Gadgeel S, Rodríguez-Abreu D, Speranza G, Esteban E, Felip E, Dómine M, Hui R, Hochmair MJ, Clingan P, Powell SF, Cheng SY, Bischoff HG, Peled N, Grossi F, Jennens RR, Reck M, Garon EB, Novello S, Rubio-Viqueira B, Boyer M, Kurata T, Gray JE, Yang J, Bas T, Pietanza MC, Garassino MC (2020) Updated analysis from KEYNOTE-189: pembrolizumab or placebo plus pemetrexed and platinum 2020 for previously untreated metastatic nonsquamous non-small-cell lung cancer. J Clin Oncol 38(14):1505–1517 PubMed
Zurück zum Zitat Gemeinsamer Bundesausschuss (2020) Tragende Gründe zum Beschluss des Gemeinsamen Bundesausschusses über eine Änderung der Arzneimittel-Richtlinie (AM-RL): Anlage XII – Nutzenbewertung von Arzneimitteln mit neuen Wirkstoffen nach § 35a SGB V Niraparib (Neubewertung eines Orphan-Drugs nach Überschreitung der 50 Mio. Euro Grenze (Ovarialkarzinom, Eileiterkarzinom oder primäre Peritonealkarzinose; Erhaltungstherapie nach Zweitlinientherapie)) vom 2. April 2020. Internet: https://​www.​g-ba.​de/​bewertungsverfah​ren/​nutzenbewertung/​500/​#beschluesse Gemeinsamer Bundesausschuss (2020) Tragende Gründe zum Beschluss des Gemeinsamen Bundesausschusses über eine Änderung der Arzneimittel-Richtlinie (AM-RL): Anlage XII – Nutzenbewertung von Arzneimitteln mit neuen Wirkstoffen nach § 35a SGB V Niraparib (Neubewertung eines Orphan-Drugs nach Überschreitung der 50 Mio. Euro Grenze (Ovarialkarzinom, Eileiterkarzinom oder primäre Peritonealkarzinose; Erhaltungstherapie nach Zweitlinientherapie)) vom 2. April 2020. Internet: https://​www.​g-ba.​de/​bewertungsverfah​ren/​nutzenbewertung/​500/​#beschluesse
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Metadaten
Titel
Onkologika
verfasst von
Prof. Dr. med. Wolf-Dieter Ludwig
Prof. em. Dr. med. Ulrich Schwabe
Copyright-Jahr
2020
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-62168-4_34

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