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06.04.2019 | Review Article

Chemotherapy and cognition: comprehensive review on doxorubicin-induced chemobrain

verfasst von: Sara Emad El-Agamy, Amal Kamal Abdel-Aziz, Ahmed Esmat, Samar S. Azab

Erschienen in: Cancer Chemotherapy and Pharmacology | Ausgabe 1/2019

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Abstract

Chemobrain refers to a common sequela experienced by a substantial subset of cancer patients exposed to chemotherapeutic treatment, a phenomenon that dramatically deteriorates the survivors’ quality of life and prevents them from restoring their pre-cancer life. This review is intended to address the current knowledge regarding the mechanisms underlying the pathophysiology of the chemobrain phenomenon, with special focus on the antineoplastic agent ‘’doxorubicin’’, which has been shown to be implicated in strenuous central neurotoxicity despite being—almost entirely—peripherally confined. Moreover, the assessment of the post-chemotherapy cognitive impairment in both human and animal subjects, and the potential pharmacotherapy and behavioral intervention strategies are reviewed.

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Titel: Chemotherapy and cognition: comprehensive review on doxorubicin-induced chemobrain
verfasst von: Sara Emad El-Agamy
Amal Kamal Abdel-Aziz
Ahmed Esmat
Samar S. Azab
Publikationsdatum: 06.04.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Cancer Chemotherapy and Pharmacology / Ausgabe 1/2019
Print ISSN: 0344-5704
Elektronische ISSN: 1432-0843
DOI: https://doi.org/10.1007/s00280-019-03827-0

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Chemotherapy and cognition: comprehensive review on doxorubicin-induced chemobrain

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