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Neurological Sciences

Erschienen in:

26.08.2021 | Review Article

Chemotherapy and peripheral neuropathy

verfasst von: Tiffany Li, David Mizrahi, David Goldstein, Matthew C. Kiernan, Susanna B. Park

Erschienen in: Neurological Sciences | Ausgabe 10/2021

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Abstract

Chemotherapy-induced peripheral neurotoxicity (CIPN) is a major dose-limiting side effect of many anti-cancer agents, including taxanes, platinums, vinca alkaloids, proteasome inhibitors, immunomodulatory drugs, and antibody–drug conjugates. The resultant symptoms often persist post treatment completion and continue to impact on long-term function and quality of life for cancer survivors. At present, dose reduction remains the only strategy to prevent severe neuropathy, often leading clinicians to the difficult decision of balancing maximal treatment exposure and minimal long-lasting side effects. This review examines the clinical presentations of CIPN with each class of neurotoxic treatment, describing signs, symptoms, and long-term outcomes. We provide an update on the proposed mechanisms of nerve damage and review current data on clinical and genetic risk factors contributing to CIPN development. We also examine recent areas of research in the treatment and prevention of CIPN, with specific focus on current clinical trials and consensus recommendations for CIPN management.

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Titel: Chemotherapy and peripheral neuropathy
verfasst von: Tiffany Li
David Mizrahi
David Goldstein
Matthew C. Kiernan
Susanna B. Park
Publikationsdatum: 26.08.2021
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 10/2021
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-021-05576-6

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Chemotherapy and peripheral neuropathy

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