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European Archives of Psychiatry and Clinical Neuroscience
Erschienen in:

05.01.2022 | Original Paper

Childhood adversity, adulthood adversity and suicidal ideation in Chinese patients with major depressive disorder: in line with stress sensitization

verfasst von: Jingyu Lin, Yunai Su, Xiaozhen Lv, Qi Liu, Gang Wang, Jing Wei, Gang Zhu, Qiaoling Chen, Hongjun Tian, Kerang Zhang, Xueyi Wang, Nan Zhang, Hong Yan, Ying Wang, Xin Yu, Tianmei Si

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 5/2022

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Abstract

The stress sensitization model indicates that early adversity (e.g., childhood stress) sensitizes individuals to subsequent proximal stress (e.g., stressful life events in adult life), thereby increasing their vulnerability to psychiatric disorders. However, the effect of stress sensitization on suicidality in patients with major depressive disorder (MDD) has not been previously investigated. Data for the present study were derived from the Objective Diagnostic Markers and Personalized Intervention in MDD Patients (ODMPIM) study. The psychiatric diagnosis and suicidal ideation were evaluated by the Mini‐International Neuropsychiatric Interview (M.I.N.I.). We used a multiple logistic analysis to examine the association among childhood adversity (CA), adulthood adversity (AA) and suicidal ideation. Among 1084 MDD patients, 48.6% had suicidal ideation and 65.6% experienced life adversity during their childhood or adulthood. Patients who reported suicidal ideation were more likely to report CA (46.7% vs. 38.7%, P = 0.008) or AA (49.5% vs. 40.9%, P = 0.004) than patients without suicidal ideation. Patients who experienced two waves of adversity (both CA and AA) were associated with higher rates of suicidal ideation (odds ratio = 1.68, 95% CI = 1.19–2.37, P = 0.003); however, neither CA nor AA alone was associated with suicidal ideation. This study first verifies the hypothesis of stress sensitization on suicidal ideation in patients with MDD. Focusing on stress sensitization may enhance the early identification of MDD patients at suicidal risk and the ability to provide timely and appropriate intervention. Clinicaltrials.gov identifier: NCT02023567.
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Metadaten
Titel
Childhood adversity, adulthood adversity and suicidal ideation in Chinese patients with major depressive disorder: in line with stress sensitization
verfasst von
Jingyu Lin
Yunai Su
Xiaozhen Lv
Qi Liu
Gang Wang
Jing Wei
Gang Zhu
Qiaoling Chen
Hongjun Tian
Kerang Zhang
Xueyi Wang
Nan Zhang
Hong Yan
Ying Wang
Xin Yu
Tianmei Si
Publikationsdatum
05.01.2022
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 5/2022
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-021-01375-4

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