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Journal of NeuroVirology

Erschienen in:

26.11.2018

Childhood trauma interacts with ApoE to influence neurocognitive function in women living with HIV

verfasst von: Jacqueline S. Womersley, Georgina Spies, Soraya Seedat, Sian M. J. Hemmings

Erschienen in: Journal of NeuroVirology | Ausgabe 2/2019

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Abstract

HIV-associated neurocognitive disorder (HAND) describes a spectrum of behavioural, motor and cognitive disturbances that can occur secondary to HIV infection. Less severe forms of the disorder persist despite advances in antiretroviral medication efficacy and availability. Childhood trauma (CT) may predispose individuals to developing HAND. As genetic variation in human apolipoprotein E (ApoE) has been implicated in cognitive decline and may mediate the development of long-term health outcomes following CT, we investigated the influence of ApoE and CT on cognitive function in the context of HIV. One hundred twenty-eight HIV-positive Xhosa women completed the Childhood Trauma Questionnaire-Short Form (CTQ-SF) as well as the HIV Neurobehavioural Research Center neurocognitive test battery. rs7412 and rs429358 were genotyped using KASP assays, and this data was used to determine the ApoE isoform. Baseline differences in demographic and clinical variables according to CT exposure were calculated. Analysis of covariance was used to assess the contributions of CT and ApoE variants, as well as their interaction, to cognitive function. Eighty-eight participants reported experiencing CT. The rs7412 C allele protected against the harmful effect of CT on motor scores using an additive model. The interaction of ApoE ε4 and CT was associated with worse attention/working memory scores. ApoE ε4, alone and in combination with CT, is associated with poorer cognitive function. Further research into this gene-environment interaction may assist in identifying at-risk individuals for targeted interventions.

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Titel: Childhood trauma interacts with ApoE to influence neurocognitive function in women living with HIV
verfasst von: Jacqueline S. Womersley
Georgina Spies
Soraya Seedat
Sian M. J. Hemmings
Publikationsdatum: 26.11.2018
Verlag: Springer International Publishing
Erschienen in: Journal of NeuroVirology / Ausgabe 2/2019
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-018-0700-y

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Update Neurologie

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Childhood trauma interacts with ApoE to influence neurocognitive function in women living with HIV

Abstract

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Manche Gestagene können das Risiko für Meningeome erhöhen

Parkinson: Größere Studie bestätigt Genauigkeit von Hauttest

Update Neurologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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Weitere Artikel der Ausgabe 2/2019

Elevated cerebrospinal fluid Galectin-9 is associated with central nervous system immune activation and poor cognitive performance in older HIV-infected individuals

Progressive multifocal leukoencephalopathy treated with nivolumab

Low-frequency fluctuation characteristics in rhesus macaques with SIV infection: a resting-state fMRI study

Various associations of aging and long-term HIV infection with different neurocognitive functions: detailed analysis of a Japanese nationwide multicenter study

Neuroinvasion of influenza A/H3N2: a fatal case in an immunocompetent adult

Simplification of combination antiretroviral therapy (cART) and the brain—a real-life experience

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Antihypertensiva schützen auch alte Menschen noch vor Demenz

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Manche Gestagene können das Risiko für Meningeome erhöhen

Parkinson: Größere Studie bestätigt Genauigkeit von Hauttest

Update Neurologie