2016 | OriginalPaper | Buchkapitel
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Onkologische Chirurgie bei alten Patienten
Das Magenkarzinom des älteren Patienten stellt eine Entität mit vielen Übereinstimmungen, aber auch mit Unterschieden im Vergleich zum Magenkarzinom des jüngeren und mittelalten Patienten dar. Die onkologische totale oder subtotale Gastrektomie inklusive radikaler Lymphadenektomie ist heutzutage in der Regel flankiert von den perioperativen chemotherapeutischen Therapieprotokollen. Sie stellt die einzige kurative Therapieoption dar, obwohl die Therapie bei älteren Patienten insgesamt mit erhöhten Raten postoperativer Morbidität und Mortalität behaftet ist. Vor dem Hintergrund der aktuellen Datenlage ist nichtsdestoweniger anzunehmen, dass auch alte Patienten mit Magenkarzinom ganz eindeutig in ihrer Lebensqualität und Lebenserwartung von der kurativen Therapie profitieren.
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Zurück zum Zitat Anter AH, Abdel-Latif RM (2013) The safety and efficacy of fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) combination in the front-line treatment for patients with advanced gastric or gastroesophageal adenocarcinoma: phase II trial. Med. Oncol. 30 (1):451. doi: 10.1007/s12032-012-0451-1 CrossRefPubMed Anter AH, Abdel-Latif RM (2013) The safety and efficacy of fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) combination in the front-line treatment for patients with advanced gastric or gastroesophageal adenocarcinoma: phase II trial. Med. Oncol. 30 (1):451. doi:
10.1007/s12032-012-0451-1
CrossRefPubMed
Zurück zum Zitat Arai T, Esaki Y, Inoshita N et al. (2004) Pathologic characteristics of gastric cancer in the elderly: a retrospective study of 994 surgical patients. Gastric Cancer 7(3):154–159. doi: 10.1007/s10120-004-0285-4 CrossRefPubMed Arai T, Esaki Y, Inoshita N et al. (2004) Pathologic characteristics of gastric cancer in the elderly: a retrospective study of 994 surgical patients. Gastric Cancer 7(3):154–159. doi:
10.1007/s10120-004-0285-4
CrossRefPubMed
Zurück zum Zitat Bonenkamp JJ, Songun I, Hermans J et al. (1995) Randomised comparison of morbidity after D1 and D2 dissection for gastric cancer in 996 Dutch patients. Lancet 345(8952):745–748 CrossRefPubMed Bonenkamp JJ, Songun I, Hermans J et al. (1995) Randomised comparison of morbidity after D1 and D2 dissection for gastric cancer in 996 Dutch patients. Lancet 345(8952):745–748
CrossRefPubMed
Zurück zum Zitat Coniglio A, Tiberio GMA, Busti M et al. (2004) Surgical treatment for gastric carcinoma in the elderly. J Surg Oncol 88(4):201–205. doi: 10.1002/jso.20153 CrossRefPubMed Coniglio A, Tiberio GMA, Busti M et al. (2004) Surgical treatment for gastric carcinoma in the elderly. J Surg Oncol 88(4):201–205. doi:
10.1002/jso.20153
CrossRefPubMed
Zurück zum Zitat Cunningham D, Allum WH, Stenning SP et al. (2006) Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N. Engl. J. Med. 355(1):11–20. doi: 10.1056/NEJMoa055531 CrossRefPubMed Cunningham D, Allum WH, Stenning SP et al. (2006) Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N. Engl. J. Med. 355(1):11–20. doi:
10.1056/NEJMoa055531
CrossRefPubMed
Zurück zum Zitat Eguchi T, Takahashi Y, Ikarashi M et al. (2000) Is extended lymph node dissection necessary for gastric cancer in elderly patients? Eur J Surg 166(12):949–953. doi: 10.1080/110241500447119 CrossRefPubMed Eguchi T, Takahashi Y, Ikarashi M et al. (2000) Is extended lymph node dissection necessary for gastric cancer in elderly patients? Eur J Surg 166(12):949–953. doi:
10.1080/110241500447119
CrossRefPubMed
Zurück zum Zitat Esaki Y, Hirayama R, Hirokawa K. A comparison of patterns of metastasis in gastric cancer by histologic type and age. Cancer. 1990 May 1;65(9):2086-90 CrossRefPubMed Esaki Y, Hirayama R, Hirokawa K. A comparison of patterns of metastasis in gastric cancer by histologic type and age. Cancer. 1990 May 1;65(9):2086-90
CrossRefPubMed
Zurück zum Zitat Fujimoto S, Takahashi M, Ohkubo H, et al. Comparative clinicopathologic features of early gastric cancer in young and older patients. Surgery 1994;115(4):516–20. PubMed Fujimoto S, Takahashi M, Ohkubo H, et al. Comparative clinicopathologic features of early gastric cancer in young and older patients. Surgery 1994;115(4):516–20.
PubMed
Zurück zum Zitat Hoeppner J, Kulemann B, Hopt UT, Marjanovic G (2014) Die total-laparoskopische Gastrektomie mit D2-Lymphadenektomie und intrakorporaler Ösophagojejunostomie in zirkulärer Staplertechnik. Zentralbl Chir. 2014 Feb;139(1):17-9. doi:10.1055/s-0033-1360122. Epub Feb 28. CrossRefPubMed Hoeppner J, Kulemann B, Hopt UT, Marjanovic G (2014) Die total-laparoskopische Gastrektomie mit D2-Lymphadenektomie und intrakorporaler Ösophagojejunostomie in zirkulärer Staplertechnik. Zentralbl Chir. 2014 Feb;139(1):17-9. doi:10.1055/s-0033-1360122. Epub Feb 28.
CrossRefPubMed
Zurück zum Zitat Homann N, Pauligk C, Luley K et al. (2012) Pathological complete remission in patients with oesophagogastric cancer receiving preoperative 5-fluorouracil, oxaliplatin and docetaxel. Int. J. Cancer 130(7):1706–1713. doi: 10.1002/ijc.26180 CrossRefPubMed Homann N, Pauligk C, Luley K et al. (2012) Pathological complete remission in patients with oesophagogastric cancer receiving preoperative 5-fluorouracil, oxaliplatin and docetaxel. Int. J. Cancer 130(7):1706–1713. doi:
10.1002/ijc.26180
CrossRefPubMed
Zurück zum Zitat Inoshita N, Yanagisawa A, Arai T et al. (1998) Pathological characteristics of gastric carcinomas in the very old. Jpn. J. Cancer Res. 89(10):1087–1092 Inoshita N, Yanagisawa A, Arai T et al. (1998) Pathological characteristics of gastric carcinomas in the very old. Jpn. J. Cancer Res. 89(10):1087–1092
Zurück zum Zitat Katai H, Sasako M, Sano T et al. (1998) The outcome of surgical treatment for gastric carcinoma in the elderly. Jpn. J. Clin. Oncol. 28(2):112–115 Katai H, Sasako M, Sano T et al. (1998) The outcome of surgical treatment for gastric carcinoma in the elderly. Jpn. J. Clin. Oncol. 28(2):112–115
Zurück zum Zitat Kripp M, Al-Batran S, Rosowski J et al. (2014) Quality of life of older adult patients receiving docetaxel-based chemotherapy triplets for esophagogastric adenocarcinoma: a randomized study of the Arbeitsgemeinschaft Internistische Onkologie (AIO). Gastric Cancer 17(1):181–187. doi: 10.1007/s10120-013-0242-1 CrossRefPubMed Kripp M, Al-Batran S, Rosowski J et al. (2014) Quality of life of older adult patients receiving docetaxel-based chemotherapy triplets for esophagogastric adenocarcinoma: a randomized study of the Arbeitsgemeinschaft Internistische Onkologie (AIO). Gastric Cancer 17(1):181–187. doi:
10.1007/s10120-013-0242-1
CrossRefPubMed
Zurück zum Zitat Kubota H, Kotoh T, Dhar DK et al. (2000) Gastric resection in the aged (or = 80 years) with gastric carcinoma: a multivariate analysis of prognostic factors. Aust N Z J Surg 70(4):254–257 CrossRefPubMed Kubota H, Kotoh T, Dhar DK et al. (2000) Gastric resection in the aged (or = 80 years) with gastric carcinoma: a multivariate analysis of prognostic factors. Aust N Z J Surg 70(4):254–257
CrossRefPubMed
Zurück zum Zitat Lorenzen S, Pauligk C, Homann N et al. (2013) Feasibility of perioperative chemotherapy with infusional 5-FU, leucovorin, and oxaliplatin with (FLOT) or without (FLO) docetaxel in elderly patients with locally advanced esophagogastric cancer. Br. J. Cancer 108(3):519–526. doi: 10.1038/bjc.2012.588 CrossRefPubMedPubMedCentral Lorenzen S, Pauligk C, Homann N et al. (2013) Feasibility of perioperative chemotherapy with infusional 5-FU, leucovorin, and oxaliplatin with (FLOT) or without (FLO) docetaxel in elderly patients with locally advanced esophagogastric cancer. Br. J. Cancer 108(3):519–526. doi:
10.1038/bjc.2012.588
CrossRefPubMedPubMedCentral
Zurück zum Zitat Nishida T, Kato M, Yoshio T et al. (2015) Endoscopic submucosal dissection in early gastric cancer in elderly patients and comorbid conditions. World J Gastrointest Endosc 7(5):524–531. doi: 10.4253/wjge.v7.i5.524 PubMedPubMedCentral Nishida T, Kato M, Yoshio T et al. (2015) Endoscopic submucosal dissection in early gastric cancer in elderly patients and comorbid conditions. World J Gastrointest Endosc 7(5):524–531. doi:
10.4253/wjge.v7.i5.524
PubMedPubMedCentral
Zurück zum Zitat Orsenigo E, Tomajer V, Di Palo S et al. (2007) Impact of age on postoperative outcomes in 1118 gastric cancer patients undergoing surgical treatment. Gastric Cancer 10(1):39–44. doi: 10.1007/s10120-006-0409-0 CrossRefPubMed Orsenigo E, Tomajer V, Di Palo S et al. (2007) Impact of age on postoperative outcomes in 1118 gastric cancer patients undergoing surgical treatment. Gastric Cancer 10(1):39–44. doi:
10.1007/s10120-006-0409-0
CrossRefPubMed
Zurück zum Zitat Robert Koch-Institut (Hrsg) und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e.V. (2014) Krebs in Deutschland 2009/2010: http://www.rki.de/Krebs/DE/Content/Publikationen/Krebs_in_Deutschland/krebs_in_ deutschland_node.html. Accessed 12 Sep 2014 Robert Koch-Institut (Hrsg) und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e.V. (2014) Krebs in Deutschland 2009/2010:
http://www.rki.de/Krebs/DE/Content/Publikationen/Krebs_in_Deutschland/krebs_in_ deutschland_node.html. Accessed 12 Sep 2014
Zurück zum Zitat Saidi RF, Bell JL, Dudrick PS (2004) Surgical resection for gastric cancer in elderly patients: is there a difference in outcome? J. Surg. Res. 118(1):15–20. doi: 10.1016/S0022-4804(03)00353-6 CrossRefPubMed Saidi RF, Bell JL, Dudrick PS (2004) Surgical resection for gastric cancer in elderly patients: is there a difference in outcome? J. Surg. Res. 118(1):15–20. doi:
10.1016/S0022-4804(03)00353-6
CrossRefPubMed
Zurück zum Zitat Saif MW, Makrilia N, Zalonis A et al. (2010) Gastric cancer in the elderly: an overview. Eur J Surg Oncol 36(8):709–717. doi: 10.1016/j.ejso.2010.05.023 CrossRefPubMed Saif MW, Makrilia N, Zalonis A et al. (2010) Gastric cancer in the elderly: an overview. Eur J Surg Oncol 36(8):709–717. doi:
10.1016/j.ejso.2010.05.023
CrossRefPubMed
Zurück zum Zitat Santoro R, Carboni F, Lepiane P et al. (2007) Clinicopathological features and prognosis of gastric cancer in young European adults. Br J Surg 94(6):737–742. doi: 10.1002/bjs.5600 CrossRefPubMed Santoro R, Carboni F, Lepiane P et al. (2007) Clinicopathological features and prognosis of gastric cancer in young European adults. Br J Surg 94(6):737–742. doi:
10.1002/bjs.5600
CrossRefPubMed
Zurück zum Zitat Sasako M (1997) Risk factors for surgical treatment in the Dutch Gastric Cancer Trial. Br J Surg 84(11):1567–1571 CrossRefPubMed Sasako M (1997) Risk factors for surgical treatment in the Dutch Gastric Cancer Trial. Br J Surg 84(11):1567–1571
CrossRefPubMed
Zurück zum Zitat Tahara E (1995) Molecular biology of gastric cancer. World J Surg 19 (4):484-8; discussion 489-90 CrossRefPubMed Tahara E (1995) Molecular biology of gastric cancer. World J Surg 19 (4):484-8; discussion 489-90
CrossRefPubMed
Zurück zum Zitat Tran TB, Worhunsky DJ, Squires MH et al. (2015) Outcomes of Gastric Cancer Resection in Octogenarians: A Multi-institutional Study of the U.S. Gastric Cancer Collaborative. Ann. Surg. Oncol. doi: 10.1245/s10434-015-4530-3 Tran TB, Worhunsky DJ, Squires MH et al. (2015) Outcomes of Gastric Cancer Resection in Octogenarians: A Multi-institutional Study of the U.S. Gastric Cancer Collaborative. Ann. Surg. Oncol. doi:
10.1245/s10434-015-4530-3
Zurück zum Zitat Winslet MC, Mohsen YM, Powell J et al. (1996) The influence of age on the surgical management of carcinoma of the stomach. Eur J Surg Oncol 22(3):220–224 CrossRefPubMed Winslet MC, Mohsen YM, Powell J et al. (1996) The influence of age on the surgical management of carcinoma of the stomach. Eur J Surg Oncol 22(3):220–224
CrossRefPubMed
Zurück zum Zitat Wu CW, Lo SS, Shen KH et al. (2000) Surgical mortality, survival, and quality of life after resection for gastric cancer in the elderly. World J Surg 24(4): 465–472 CrossRefPubMed Wu CW, Lo SS, Shen KH et al. (2000) Surgical mortality, survival, and quality of life after resection for gastric cancer in the elderly. World J Surg 24(4): 465–472
CrossRefPubMed
Zurück zum Zitat Ychou M, Boige V, Pignon J et al. (2011) Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial. J. Clin. Oncol. 29(13): 1715–1721. doi: 10.1200/JCO.2010.33.0597 CrossRefPubMed Ychou M, Boige V, Pignon J et al. (2011) Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial. J. Clin. Oncol. 29(13): 1715–1721. doi:
10.1200/JCO.2010.33.0597
CrossRefPubMed
Zurück zum Zitat Zhang Y, Wu Y, Lu G et al. (2015) Systematic review and meta-analysis of totally laparoscopic versus laparoscopic assisted distal gastrectomy for gastric cancer. World J Surg Oncol 13: 116. doi: 10.1186/s12957-015-0532-7 CrossRefPubMedPubMedCentral Zhang Y, Wu Y, Lu G et al. (2015) Systematic review and meta-analysis of totally laparoscopic versus laparoscopic assisted distal gastrectomy for gastric cancer. World J Surg Oncol 13: 116. doi:
10.1186/s12957-015-0532-7
CrossRefPubMedPubMedCentral
- Titel
- Chirurgie des Magenkarzinoms bei alten Patienten
- DOI
- https://doi.org/10.1007/978-3-662-48712-9_15
- Autoren:
-
J. Höppner
T. Glatz
- Verlag
- Springer Berlin Heidelberg
- Sequenznummer
- 15
- Kapitelnummer
- 15