2016 | OriginalPaper | Buchkapitel
Erschienen in:
Onkologische Chirurgie bei alten Patienten
In diesem Kapitel werden die Grundzüge der Behandlung von WeichteilsarkomeWeichteilsarkomn des alten Patienten primär aus chirurgischer Sicht dargestellt. Die wichtigsten Fakten in den Bereichen Epidemiologie, Klinik, Diagnostik und Klassifikation werden übersichtlich zusammengefasst. Der Hauptfokus liegt auf der adäquaten onkochirurgischen und rekonstruktiven Behandlung von Weichteilsarkomen an den Extremitäten. Die wesentlichen Prinzipien der interdisziplinären und multimodalen Behandlung werden unter besonderer Berücksichtigung der Behandlung von älteren Patienten erläutert.
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Zurück zum Zitat Bannasch H, Eisenhardt SU, Grosu AL, Heinz J, Momeni A, Stark GB (2011) The diagnosis and treatment of soft tissue sarcomas of the limbs. Dtsch Arztebl Int 108(3):32-38 PubMedPubMedCentral Bannasch H, Eisenhardt SU, Grosu AL, Heinz J, Momeni A, Stark GB (2011) The diagnosis and treatment of soft tissue sarcomas of the limbs. Dtsch Arztebl Int 108(3):32-38
PubMedPubMedCentral
Zurück zum Zitat Canter RJ, Smith CA, Martinez SR, Goodnight JE Jr, Bold RJ, Wisner DH (2013) Extremity soft tissue tumor surgery by surgical specialty: a comparison of case volume among oncology and non-oncology-designated surgeons. J Surg Oncol 108(3):142-147 CrossRefPubMed Canter RJ, Smith CA, Martinez SR, Goodnight JE Jr, Bold RJ, Wisner DH (2013) Extremity soft tissue tumor surgery by surgical specialty: a comparison of case volume among oncology and non-oncology-designated surgeons. J Surg Oncol 108(3):142-147
CrossRefPubMed
Zurück zum Zitat Daigeler A, Kuhnen C, Moritz R, Stricker I, Goertz O et al (2009) Lymph node metastases in soft tissue sarcomas: a single center analysis of 1,597 patients. Langenbecks Arch Surg. 394(2):321-329 CrossRefPubMed Daigeler A, Kuhnen C, Moritz R, Stricker I, Goertz O et al (2009) Lymph node metastases in soft tissue sarcomas: a single center analysis of 1,597 patients. Langenbecks Arch Surg. 394(2):321-329
CrossRefPubMed
Zurück zum Zitat Garbay D, Maki RG, Blay JY, Isambert N, Piperno Neumann S et al (2013) Advanced soft-tissue sarcoma in elderly patients: patterns of care and survival. Ann Oncol 24(7):1924-1930 CrossRefPubMed Garbay D, Maki RG, Blay JY, Isambert N, Piperno Neumann S et al (2013) Advanced soft-tissue sarcoma in elderly patients: patterns of care and survival. Ann Oncol 24(7):1924-1930
CrossRefPubMed
Zurück zum Zitat Hoven-Gondrie ML, Bastiaannet E, van Ginkel RJ, Suurmeijer AJ, Hoekstra HJ (2011) TNF dose reduction and shortening of duration of isolated limb perfusion for locally advanced soft tissue sarcoma of the extremities is safe and effective in terms of long-term patient outcome. J Surg Oncol 103(7):648-645 CrossRefPubMed Hoven-Gondrie ML, Bastiaannet E, van Ginkel RJ, Suurmeijer AJ, Hoekstra HJ (2011) TNF dose reduction and shortening of duration of isolated limb perfusion for locally advanced soft tissue sarcoma of the extremities is safe and effective in terms of long-term patient outcome. J Surg Oncol 103(7):648-645
CrossRefPubMed
Zurück zum Zitat Issels RD, Lindner LH, Verweij J, Wust P, Reichardt P et al; European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group (EORTC-STBSG); European Society for Hyperthermic Oncology (ESHO) (2010) Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study. Lancet Oncol. 11(6):561-570 Issels RD, Lindner LH, Verweij J, Wust P, Reichardt P et al; European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group (EORTC-STBSG); European Society for Hyperthermic Oncology (ESHO) (2010) Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study. Lancet Oncol. 11(6):561-570
Zurück zum Zitat Jo VY, Fletcher CD (2014) WHO classification of soft tissue tumours: an update based on the 2013 (4th) edition. Pathology 46(2):95-104 CrossRefPubMed Jo VY, Fletcher CD (2014) WHO classification of soft tissue tumours: an update based on the 2013 (4th) edition. Pathology 46(2):95-104
CrossRefPubMed
Zurück zum Zitat Kandel R, Coakley N, Werier J, Engel J, Ghert M, Verma S; Sarcoma Disease Site Group of Cancer Care Ontario’s Program in Evidence-Based Care (2013) Surgical margins and handling of soft-tissue sarcoma in extremities: a clinical practice guideline. Curr Oncol 20(3):e247-54 CrossRef Kandel R, Coakley N, Werier J, Engel J, Ghert M, Verma S; Sarcoma Disease Site Group of Cancer Care Ontario’s Program in Evidence-Based Care (2013) Surgical margins and handling of soft-tissue sarcoma in extremities: a clinical practice guideline. Curr Oncol 20(3):e247-54
CrossRef
Zurück zum Zitat Kozawa E, Sugiura H, Tsukushi S, Urakawa H, Arai E et al (2014) Multiple primary malignancies in elderly patients with high-grade soft tissue sarcoma. Int J Clin Oncol 19(2):384-3 CrossRefPubMed Kozawa E, Sugiura H, Tsukushi S, Urakawa H, Arai E et al (2014) Multiple primary malignancies in elderly patients with high-grade soft tissue sarcoma. Int J Clin Oncol 19(2):384-3
CrossRefPubMed
Zurück zum Zitat Kraus-Tiefenbacher US, Van Kampen M (2015) Current Trends in Radiotherapy Following Surgical Resection of Soft-tissue Sarcoma of the Extremities and Trunk. Handchir Mikrochir Plast Chir 47(2):128-133 CrossRefPubMed Kraus-Tiefenbacher US, Van Kampen M (2015) Current Trends in Radiotherapy Following Surgical Resection of Soft-tissue Sarcoma of the Extremities and Trunk. Handchir Mikrochir Plast Chir 47(2):128-133
CrossRefPubMed
Zurück zum Zitat Lahat G, Tuvin D, Wei C, Anaya DA, Bekele BNet al (2008) New perspectives for staging and prognosis in soft tissue sarcoma. Ann Surg Oncol (10):2739-2748 CrossRef Lahat G, Tuvin D, Wei C, Anaya DA, Bekele BNet al (2008) New perspectives for staging and prognosis in soft tissue sarcoma. Ann Surg Oncol (10):2739-2748
CrossRef
Zurück zum Zitat Le Cesne A, Ouali M, Leahy MG, Santoro A, Hoekstra HJ et al (2014) Doxorubicin-based adjuvant chemotherapy in soft tissue sarcoma: pooled analysis of two STBSG-EORTC phase III clinical trials. Ann Oncol. 25(12):2425-2432 CrossRefPubMed Le Cesne A, Ouali M, Leahy MG, Santoro A, Hoekstra HJ et al (2014) Doxorubicin-based adjuvant chemotherapy in soft tissue sarcoma: pooled analysis of two STBSG-EORTC phase III clinical trials. Ann Oncol. 25(12):2425-2432
CrossRefPubMed
Zurück zum Zitat Maretty-Nielsen K, Aggerholm-Pedersen N, Safwat A, Baerentzen S, Pedersen AB, Keller J (2014a) Prevalence and prognostic impact of comorbidity in soft tissue sarcoma: a population-based cohort study. Acta Oncol 53(9):1188-1196 CrossRefPubMed Maretty-Nielsen K, Aggerholm-Pedersen N, Safwat A, Baerentzen S, Pedersen AB, Keller J (2014a) Prevalence and prognostic impact of comorbidity in soft tissue sarcoma: a population-based cohort study. Acta Oncol 53(9):1188-1196
CrossRefPubMed
Zurück zum Zitat Maretty-Nielsen K, Aggerholm-Pedersen N, Safwat A, Jørgensen PH, Hansen BH et al (2014b) Prognostic factors for local recurrence and mortality in adult soft tissue sarcoma of the extremities and trunk wall: a cohort study of 922 consecutive patients. Acta Orthop 85(3):323-332 CrossRefPubMedPubMedCentral Maretty-Nielsen K, Aggerholm-Pedersen N, Safwat A, Jørgensen PH, Hansen BH et al (2014b) Prognostic factors for local recurrence and mortality in adult soft tissue sarcoma of the extremities and trunk wall: a cohort study of 922 consecutive patients. Acta Orthop 85(3):323-332
CrossRefPubMedPubMedCentral
Zurück zum Zitat O′Sullivan B, Davis AM, Turcotte R, Bell R, Catton C et al (2002) Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial. Lancet 359:2235-2241 CrossRefPubMed O′Sullivan B, Davis AM, Turcotte R, Bell R, Catton C et al (2002) Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial. Lancet 359:2235-2241
CrossRefPubMed
Zurück zum Zitat Pisters PW, Harrison LB, Leung DH, Woodruff JM, Casper ES, Brennan MF (1996) Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma. J Clin Oncol. (3):859-856 Pisters PW, Harrison LB, Leung DH, Woodruff JM, Casper ES, Brennan MF (1996) Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma. J Clin Oncol. (3):859-856
Zurück zum Zitat Reichardt P, Pink D, Tilgner J, Kretzschmar A, Thuss-Patience PC, Dörken B (2002) Oral trofosfamide: an active and well-tolerated maintenance therapy for adult patients with advanced bone and soft tissue sarcomas. Results of a retrospective analysis. Onkologie. 25(6):541-546 PubMed Reichardt P, Pink D, Tilgner J, Kretzschmar A, Thuss-Patience PC, Dörken B (2002) Oral trofosfamide: an active and well-tolerated maintenance therapy for adult patients with advanced bone and soft tissue sarcomas. Results of a retrospective analysis. Onkologie. 25(6):541-546
PubMed
Zurück zum Zitat Schütte J, Hartmann JT, Reichardt P, Issels RD, Tunn PU, Budach V (2011) Weichteilsarkome, Leitlinie der DGHO ( https://www.dgho-onkopedia.de/de/onkopedia/leitlinien/weichteilsarkome) Schütte J, Hartmann JT, Reichardt P, Issels RD, Tunn PU, Budach V (2011) Weichteilsarkome, Leitlinie der DGHO (
https://www.dgho-onkopedia.de/de/onkopedia/leitlinien/weichteilsarkome)
Zurück zum Zitat Soyfer V, Corn BW, Kollender Y, Issakov J, Dadia S et al (2013) Hypofractionated adjuvant radiation therapy of soft-tissue sarcoma achieves excellent results in elderly patients. Br J Radiol. 86(1028):20130258 CrossRefPubMedPubMedCentral Soyfer V, Corn BW, Kollender Y, Issakov J, Dadia S et al (2013) Hypofractionated adjuvant radiation therapy of soft-tissue sarcoma achieves excellent results in elderly patients. Br J Radiol. 86(1028):20130258
CrossRefPubMedPubMedCentral
Zurück zum Zitat Steinau HU, Daigeler A, Langer S, Steinsträsser L, Hauser J et al (2010) Limb salvage in malignant tumors. Semin Plast Surg 24(1):18-33 CrossRefPubMedPubMedCentral Steinau HU, Daigeler A, Langer S, Steinsträsser L, Hauser J et al (2010) Limb salvage in malignant tumors. Semin Plast Surg 24(1):18-33
CrossRefPubMedPubMedCentral
Zurück zum Zitat van Etten B, van Geel AN, de Wilt JH, Eggermont AM (2003) Fifty tumor necrosis factor-based isolated limb perfusions for limb salvage in patients older than 75 years with limb-threatening soft tissue sarcomas and other extremity tumors. Ann Surg Oncol 10(1):32-37 CrossRefPubMed van Etten B, van Geel AN, de Wilt JH, Eggermont AM (2003) Fifty tumor necrosis factor-based isolated limb perfusions for limb salvage in patients older than 75 years with limb-threatening soft tissue sarcomas and other extremity tumors. Ann Surg Oncol 10(1):32-37
CrossRefPubMed
Zurück zum Zitat Wong AK, Joanna Nguyen T, Peric M, Shahabi A, Vidar EN et al (2015) Analysis of risk factors associated with microvascular free flap failure using a multi-institutional database. Microsurgery 35(1):6-12 CrossRefPubMed Wong AK, Joanna Nguyen T, Peric M, Shahabi A, Vidar EN et al (2015) Analysis of risk factors associated with microvascular free flap failure using a multi-institutional database. Microsurgery 35(1):6-12
CrossRefPubMed
Zurück zum Zitat Yang JC, Chang AE, Baker AR, Sindelar WF, Danforth DN et al (1998) Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol 16(1):197-203 PubMed Yang JC, Chang AE, Baker AR, Sindelar WF, Danforth DN et al (1998) Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol 16(1):197-203
PubMed
Zurück zum Zitat Yoneda Y, Kunisada T, Naka N, Nishida Y, Kawai A et al (2014) Favorable outcome after complete resection in elderly soft tissue sarcoma patients: Eur J Surg Oncol 40(1):49-54 CrossRefPubMed Yoneda Y, Kunisada T, Naka N, Nishida Y, Kawai A et al (2014) Favorable outcome after complete resection in elderly soft tissue sarcoma patients: Eur J Surg Oncol 40(1):49-54
CrossRefPubMed
Zurück zum Zitat Yuen NK, Li CS, Monjazeb AM, Borys D, Bold RJ, Canter RJ (2015) Older age impacts radiotherapy-related outcomes in soft tissue sarcoma.J Surg Res. pii: S0022-4804(15)00703-9 Yuen NK, Li CS, Monjazeb AM, Borys D, Bold RJ, Canter RJ (2015) Older age impacts radiotherapy-related outcomes in soft tissue sarcoma.J Surg Res. pii: S0022-4804(15)00703-9
- Titel
- Chirurgie von Sarkomen bei alten Patienten
- DOI
- https://doi.org/10.1007/978-3-662-48712-9_23
- Autoren:
-
H. Bannasch
G. Koulaxouzidis
- Verlag
- Springer Berlin Heidelberg
- Sequenznummer
- 23
- Kapitelnummer
- 23