Skip to main content
main-content

01.08.2011 | Review | Ausgabe 4/2011

Breast Cancer Research 4/2011

Choosing the right cell line for breast cancer research

Zeitschrift:
Breast Cancer Research > Ausgabe 4/2011
Autoren:
Deborah L Holliday, Valerie Speirs
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​bcr2889) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Abstract

Breast cancer is a complex and heterogeneous disease. Gene expression profiling has contributed significantly to our understanding of this heterogeneity at a molecular level, refining taxonomy based on simple measures such as histological type, tumour grade, lymph node status and the presence of predictive markers like oestrogen receptor and human epidermal growth factor receptor 2 (HER2) to a more sophisticated classification comprising luminal A, luminal B, basal-like, HER2-positive and normal subgroups. In the laboratory, breast cancer is often modelled using established cell lines. In the present review we discuss some of the issues surrounding the use of breast cancer cell lines as experimental models, in light of these revised clinical classifications, and put forward suggestions for improving their use in translational breast cancer research.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Zusatzmaterial
Authors’ original file for figure 1
13058_2011_2719_MOESM1_ESM.tiff
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 4/2011

Breast Cancer Research 4/2011 Zur Ausgabe

Neu im Fachgebiet Onkologie

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Onkologie und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise